A5100622157- Liver physiology and pathology
- MicroRNA in disease regulation
- Helicobacter pylori-related gastroenterology studies
- Fibroblast Growth Factor Research
- Ophthalmology and Eye Disorders
- Gastric Cancer Management and Outcomes
- Mesenchymal stem cell research
- Protein Tyrosine Phosphatases
- Liver Disease Diagnosis and Treatment
- Olfactory and Sensory Function Studies
- Liver Disease and Transplantation
- Pancreatic function and diabetes
- Veterinary medicine and infectious diseases
- Growth Hormone and Insulin-like Growth Factors
- Organ Transplantation Techniques and Outcomes
- Estrogen and related hormone effects
- Proteoglycans and glycosaminoglycans research
- Eosinophilic Esophagitis
- Angiogenesis and VEGF in Cancer
- Mechanisms of cancer metastasis
- Plant-derived Lignans Synthesis and Bioactivity
- Neuroscience and Neuropharmacology Research
- Endometriosis Research and Treatment
- Biochemical Analysis and Sensing Techniques
- Magnolia and Illicium research
CHA University
2018-2025
University of California, San Francisco
2022-2024
Seoul National University
2011-2023
CHA Bundang Medical Center
2020
Daegu Gyeongbuk Institute of Science and Technology
2017-2020
CHA Gangnam Medical Center
2018
Johns Hopkins University
2014
Sookmyung Women's University
2005-2011
Chonnam National University
2007
Hanyang University
2007
Antimicrobial resistance of Helicobacter pylori (H. pylori) affects the efficacy eradication therapy. The aim this study was to estimate prevalence primary and secondary H. isolates antibiotics characterize risk factors associated with antimicrobial in Korea.This performed during period 2003-2012. Primary evaluated from 347 patients without any history eradication, 86 whom cultured after failure eradication. Minimal inhibitory concentration test for amoxicillin, clarithromycin,...
Neuritogenesis is crucial for establishing proper neuronal connections during brain development; its failure causes neurodevelopmental defects. Cullin-RING E3 ubiquitin ligase complexes participate in various processes by regulating protein stability. We demonstrated the regulatory function of 4 (CRL4) neurite morphogenesis early neurodevelopment. Cul4a and Cul4b, core scaffold proteins CRL4, exhibit high expression activation within cytosol developing neurons, regulated stimulation through...
Background/Aims This study was performed to compare the prevalence rates of primary antibiotic resistance in Helicobacter pylori (H. pylori) isolates among different regions Korea. Methods H. were isolated from gastric mucosal biopsy specimens 99 Koreans who lived Gyeonggi (n=40), Kangwon province (n=40) and Busan (n=19) April August 2008. All patients had no history eradication therapy. The susceptibilities amoxicillin, clarithromycin, metronidazole, tetracycline, azithromycin,...
The overproduction of nitric oxide (NO) by inducible synthase (iNOS) switches the function NO from a physiological neuromodulator to neurotoxic effector in central nervous system (CNS) after brain injury. From methanol extracts Psoralea corylifolia, we purified two inhibitors production lipopolysaccharide (LPS)-activated microglia activity guided purification along with inactive compounds. active compounds were identified as chromenoflavanone...
Abstract Olfactory dysfunction is a common symptom associated with neurodegenerative diseases including Alzheimer’s disease (AD). Although evidence exists to suggest that peripheral olfactory organs are involved in the accompanies AD pathology, underlying mechanisms not fully understood. As confirmed using behavioral tests, transgenic mice overexpressing Swedish mutant form of human amyloid precursor proteins exhibited impairments prior cognitive impairment. By measuring expression tyrosine...
Background/Aims: Epithelial-to-mesenchymal transition (EMT) plays a crucial role in hepatic fibrogenesis and liver repair chronic disease.Our research highlights the antifibrotic potential of placenta-derived mesenchymal stem cells (PD-MSCs) phosphatase regenerating liver-1 (PRL-1) promoting regeneration. Methods:We evaluated efficacy PD-MSCs overexpressing PRL-1 (PD-MSCs ) bile duct ligation (BDL)-induced rat injury model, focusing on their ability to regulate EMT.Results: significantly...
Objective. The eradication rate of 10-day sequential therapy for Helicobacter pylori (H. pylori) infection was not satisfactory in Korea, probably due to antibiotic resistance. To compare the treatment efficacy 15-day and conventional 7-day proton pump inhibitor (PPI) triple H. infection. Methods. A total 332 patients with were randomly assigned receive either PPI therapy, or therapy. Eradication rate, drug compliance, adverse events compared among three regimens. Results. rates by...
Although the liver has a regenerative capacity, hepatic failure is severe and irreversible chronic disease. Placenta-derived mesenchymal stem cells (PD-MSCs) have distinctive features, such as recycling of placenta waste after birth, ease accessibility, abundant cell numbers, strong immunosuppressive properties. Previously, we reported that PD-MSCs can regenerate in through antifibrotic autophagic mechanisms. Many reports investigated whether exosomes, which are formed by budding vesicular...
A new sesquiterpene lactone was isolated from Siegesbeckia glabrescens as an inhibitor of nitric oxide and prostaglandin E 2 synthesis in the LPS‐activated RAW264.7 macrophage cell line. It dose‐dependently decreased protein mRNA levels inducible synthase cyclooxygenase‐2. Reporter gene assay revealed that compound attenuated LPS‐induced DNA transcriptional activity nuclear factor‐kappa B (NF‐κB). In addition, it inhibited translocation p65 subunit NF‐κB by blocking inhibitory kappa B‐α...
Placenta-derived mesenchymal stem cells (PD-MSCs) were highlighted as therapeutic sources in several degenerative diseases. Recently, microRNAs (miRNAs)were found to mediate one of the mechanisms PD-MSCs regenerative medicine. To enhance effects PD-MSCs, we established functionally enhanced with phosphatase regenerating liver-1 overexpression (PRL-1(+)). However, profile and functions miRNAs induced by PRL-1(+) a rat model hepatic failure prepared bile duct ligation (BDL) remained unclear....
Oxidative stress induces damages of various cell types or tissues through a repetitive imbalance between the systemic manifestation reactive oxygen species (ROS) and detoxification intermediates. Thioacetamide (TAA) is well known for causing several degenerative diseases by oxidative stress. However, study antioxidant mechanisms stem cells in TAA-injured rat model insufficient. Therefore, we investigated effect placenta-derived mesenchymal (PD-MSCs) transplantation on liver ovary models to...
Background/Aims This study was performed to evaluate whether the prevalence rates of primary antibiotic resistance in Helicobacter pylori (H. pylori) isolates and eradication rate H. could be different between cancer non-cancer patients. Methods were isolated from gastric mucosal biopsy specimens obtained 269 Koreans, who did not have any therapy history diagnosed as one following diseases; chronic gastritis, benign ulcer, duodenal ulcer or cancer. The susceptibilities amoxicillin,...
Placenta-derived mesenchymal stem cells (PD-MSCs) have unique immunomodulatory properties. Phosphatase of regenerating liver-1 (PRL-1) regulates the self-renewal ability and promotes proliferation. Graves' ophthalmopathy (GO) is an autoimmune inflammatory disease orbit characterized by increased orbital levels adipose tissue. Here, we evaluated therapeutic mechanism for regulation adipogenesis PRL-1-overexpressing PD-MSCs (PD-MSCsPRL-1, PRL-1+) in fibroblast (OF) with GO patients.PD-MSCs...
Abstract Background Cholesterol accumulation and calcium depletion induce hepatic injury via the endoplasmic reticulum (ER) stress response. ER regulates imbalance between mitochondria. We previously reported that phosphatase of regenerating liver-1 (PRL-1)-overexpressing placenta-derived mesenchymal stem cells (PD-MSCs PRL−1 ) promoted liver regeneration mitochondrial dynamics in a cirrhotic rat model. However, role PRL-1 stress-dependent is not clear. Therefore, we demonstrated PD-MSCs...
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Hexapeptide WKYMVm (Trp-Lys-Tyr-Met-Val-D-Met), a ligand of formyl peptide receptor 2, exhibits anti-inflammatory and angiogenic properties in disease models. However, the therapeutic effects on hepatic fibrosis have not been evaluated to date. Therefore, we investigated whether exerts antifibrotic induces vascular regeneration rat model bile duct ligation (BDL). The liver BDL were analyzed using biochemical assays, qRT-PCR, western blotting, immunofluorescence, immunohistochemistry. To...
Abstract Background Graves’ ophthalmopathy (GO) is a disorder, in which orbital connective tissues get inflammation and increase volume. Stimulants such as thyroid-stimulating hormone (TSH), insulin-like growth factor 1(IGF-1), IL-1, interferon γ, platelet-derived cause differentiation into adipocytes of fibroblasts (OFs) the fat extraocular muscles. Human placental mesenchymal stem cells (hPMSCs) are known to have immune modulation effects on disease pathogenesis. Some reports suggest that...
Retinal degenerative diseases result from oxidative stress and mitochondrial dysfunction, leading to the loss of visual acuity. Damaged retinal pigment epithelial (RPE) photoreceptor cells undergo mitophagy. Pigment epithelium-derived factor (PEDF) protects in RPE improves functions. Overexpression PEDF placenta-derived mesenchymal stem (PD-MSCs; PD-MSCsPEDF) provides therapeutic effects diseases. Here, we investigated whether PD-MSCsPEDF restored cycle through a mitophagic mechanism...
Gastric mucosal expression of interleukin (IL)-1β may alter acid secretion and influence the development gastroesophageal reflux disease (GERD). The relationship gastric IL-1β level GERD was evaluated in Korean population.Genotypes IL-1B-511 IL-1RN VNTR polymorphism clinical characteristics were analyzed 44 patients with erosive esophagitis (EE), 32 minimal change lesions (MCL), 54 non-erosive (NERD) 113 controls. levels measured by enzyme linked immunosorbent assay.Significant differences...
Placenta-derived mesenchymal stem cells (PD-MSCs) have been highlighted as an alternative cell therapy agent that has become a next-generation treatment. Phosphatase of regenerating liver-1 (PRL-1), immediate early gene, plays critical role during liver regeneration. Here, we generated enhanced PRL-1 in PD-MSCs (PD-MSCsPRL-1, PRL-1+) using lentiviral and nonviral gene delivery systems investigated mitochondrial functions by PD-MSCPRL-1 transplantation for hepatic rat bile duct ligation (BDL)...