A5008710414- Mesenchymal stem cell research
- Oral microbiology and periodontitis research
- Liver physiology and pathology
- Food Quality and Safety Studies
- Particle physics theoretical and experimental studies
- Pharmacological Effects of Natural Compounds
- Quantum Chromodynamics and Particle Interactions
- Garlic and Onion Studies
- High-Energy Particle Collisions Research
- MicroRNA in disease regulation
- Ginseng Biological Effects and Applications
- Educational Systems and Policies
- Dental Health and Care Utilization
- Genomics, phytochemicals, and oxidative stress
- Organ Transplantation Techniques and Outcomes
- Phytochemicals and Antioxidant Activities
- Endodontics and Root Canal Treatments
- Energy Efficient Wireless Sensor Networks
- Protein Tyrosine Phosphatases
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- NF-κB Signaling Pathways
- Bacteriophages and microbial interactions
- Microbial Metabolism and Applications
Korea Electronics Technology Institute
2012-2024
Rural Development Administration
2022-2024
Pusan National University
2023-2024
Jeonbuk National University
2012-2024
Sookmyung Women's University
2023
Instituto de Ciencias Agrarias
2022
CHA University
2010-2020
American Red Cross
2020
Seoul National University
2005-2019
Konkuk University
2014-2018
Blocking phosphorylation of peroxisome proliferator-activated receptor (PPAR)γ at Ser(273) is one the key mechanisms for antidiabetes drugs to target PPARγ. Using high-throughput screening, we here describe that Gleevec blocks cyclin-dependent kinase 5-mediated PPARγ devoid classical agonism as a antagonist ligand. In high fat-fed mice, improved insulin sensitivity without causing severe side effects associated with other PPARγ-targeting drugs. Furthermore, reduces lipogenic and...
Translational studies have explored the therapeutic effects of stem cells, raising hopes for treatment numerous diseases. Here, we evaluated effect chorionic plate-derived mesenchymal cells (CP-MSCs) isolated from human placenta and transplanted into rats with carbon tetrachloride (CCl(4))-injured livers. CP-MSCs were analyzed hepatocyte-specific gene expression, indocyanine green (ICG) uptake, glycogen storage, urea production following hepatogenic differentiation. PKH26-labeled directly...
Mesenchymal stem cells (MSCs) have great potential for cell therapy in regenerative medicine, including liver disease. Even though ongoing research is dedicated to the goal of bringing MSCs clinical applications, further understanding complex underlying mechanisms required. Autophagy, a type II programmed death, controls cellular recycling through lysosomal system damaged or tissues. However, it still unknown whether can trigger autophagy enhance regeneration and/or provide therapeutic...
Ginsenosides, which are bioactive components in ginseng, can be converted to smaller compounds for improvement of their pharmacological activities. The conversion methods include heating; acid, alkali, and enzymatic treatment; microbial conversion. aim this study was determine the bioconversion ginsenosides fermented red ginseng extract (FRGE).Red (RGE) using Lactobacillus plantarum KCCM 11613P. This investigated antioxidant capacity FRGE diverse methods.Properties RGE were changed upon...
Abstract Hypoxia triggers physiological and pathological cellular processes, including proliferation, differentiation, death, in several cell types. Mesenchymal stem cells (MSCs) derived from various tissues have self‐renewal activity can differentiate towards multiple lineages. Recently, it has been reported that hypoxic conditions tip the balance between survival death by hypoxia‐induced autophagy, although underlying mechanism is not clear. The objectives of this study are to compare...
This study investigated the influence of polyphenol‐rich grape skin extract ( GSE ) on adiposity and hepatic steatosis in mice fed a high fat diet HFD its underlying mechanisms based adipose lipid metabolism. C57BL/6J were normal or (20% fat, w/w) with without (0.15%, for 10 weeks. The supplementation significantly lowered body weight, plasma free fatty acid level, accumulation compared to group. Plasma leptin level was lower, while adiponectin higher group than suppressed activities...
The objective of this study was to investigate characteristics and functionality yogurt applied red ginseng extract. Yogurts added with extract (0.5, 1, 1.5, 2%) were produced using Lactobacillus acidophilus Streptococcus thermophilus stored at refrigerated temperature. During fermentation, pH decreased whereas titratable aicidity viable cell counts L. S. increased. composition samples measured on day an increase content in resulted lactose, protein, total solids, ash content, fat moisture...
Abstract Purpose: Because the biological significance of constitutive nuclear factor-κB (NF-κB) activation in human gastric cancer is unclear, we undertook this study to clarify regulatory mechanism NF-κB and its clinical significance. Experimental Design: Immunohistochemistry for NF-κB/RelA was done on 290 carcinoma specimens placed tissue array slides. The correlations between clinicopathologic features, prognosis, Akt activation, tumor suppressor gene expression, or Bcl-2 expression were...
Underlying mechanisms involved in the activation of hypoxia-inducible factor-1 (HIF-1) cancer cells are diverse and cell type specific. Although both HIF-1α AKT (protein kinase B) have been implicated gastric tumor promotion angiogenesis, it remains unclear whether HIF-1 mediates role terms promoting vascular endothelial growth factor (VEGF) expression. The present study was performed to investigate correlation between using human specimens, vitro experiments vivo animal experiments....
Fluoride is commonly used as an ingredient of topical oral hygiene measures. Despite the anti-acidogenic activities fluoride against cariogenic biofilms, recovery biofilms from damage unclear. Herein, we investigated acid production in <i>Streptococcus mutans </i>biofilms after short-term or during periodic 1-min treatments. For this study, 46-hour-old <i>S. mutans</i> were treated with (0-2,000 ppm F<sup>-</sup>) for 1-8 min and then incubated saliva...
Human chorionic plate-derived mesenchymal stem cells (CP-MSCs) isolated from the placenta have been reported to demonstrate therapeutic effects in animal models of liver injury; however, underlying epigenetic mechanism this effect has not elucidated. Thus, we investigated whether CP-MSCs influence processes during regeneration injured liver.CP-MSCs were engrafted into a carbon tetrachloride (CCl4)-injured rat model through direct transplantation (DTX), intrasplenic (STX), and intravenous via...
Sucrose is an important dietary factor in cariogenic biofilm formation and subsequent initiation of dental caries. This study investigated the functional relationships between sucrose concentration Streptococcus mutans adherence formation. Changes morphological characteristics biofilms with increasing were also evaluated. S. formed on saliva-coated hydroxyapatite discs culture medium containing 0, 0.05, 0.1, 0.5, 1, 2, 5, 10, 20, or 40% (w/v) sucrose. The (in 4-hour biofilms) composition...
The relationship between sugar level and development of dental caries has long been a main topic in dentistry. However, as ubiquitous component the modern diet, sucrose is mainly derived from three meals day, rather than time exposure. In this study, various concentrations were provided to Streptococcus mutans biofilms for 1 h per exposure (three times day) imitate human meal pattern. And then concentration changes treated was determined. results indicated that components acid production...
There is a growing body of evidence that small subpopulations cells with stem cell-like characteristics within most solid tumors are responsible for the malignancy aggressive cancer and targeting these might be good therapeutic strategy to reduce risk tumor relapse after therapy. Here, we examined effects emodin (1,3,8-trihydroxy-6-methylanthraquinone), an active component root rhizome Rheum palmatum has several biological activities, including antitumor effects, on primary cultured glioma...
Fluoride is a well-studied and widely used agent for the prevention of dental caries. Although caries strongly related to cariogenic biofilms, effect brief fluoride treatment on virulence properties biofilms has not been well studied. This study evaluated 1-min viability using <i>Streptococcus mutans</i> biofilm model. For this study, 46-hour-old <i>S. were formed saliva-coated hydroxyapatite discs treated with (0, 30, 300, 1,000, 2,000 ppm F<sup>-</sup>) 1 min....
Although hypoxic environments have been known to regulate the migratory ability of bone marrow‐derived mesenchymal stem cells (BM‐MSCs), which is a critical factor for maximizing therapeutic effect, underlying mechanisms remain unclear. Therefore, we aimed confirm effect hypoxia‐inducible factor‐1 α (HIF‐1 ) on migration BM‐MSCs and analyze interaction between HIF‐1 integrin‐mediated signals. Hypoxia‐activated significantly increased BM‐MSC migration. The expression integrin 4 was decreased...
Neural stem cells (NSCs) have a high potency for differentiation to neurons and glial replacement of damaged paracrine effects the regeneration remyelination host axons. Dental pulp is known potential differentiate into neural‐like cells; therefore, dental may be used as an autologous cell source neural repair. In this study, we selectively expanded from human in initial culture using NSC media under xeno‐ serum‐free conditions. At step primary culture, was divided two groups according...
This study was conducted to evaluate and increase the usage of whole onion (Allium cepa L.), which is composed a small bulb many leaves that are discarded as by-products before bulbs grow. Whole onions harvested early in immature condition, allows other grow well. We compared its functional activities with those quercetin, one major components. The antioxidant ethanol extract from (WOEE) were measured by DPPH ABTS radical scavenging activities, superoxide dismutase (SOD) catalase (CAT)...
Allium cepa L. (onion) has been reported to have various pharmacological effects, such as preventing heart disease, and improving antimicrobial activity immunological effects. The Republic of Korea produced 1,195,563 tons onions (2022). flesh onion is used food while the skin (OS) thrown away an agro-food by-product considered induce environmental pollution. Thus, we hypothesize that increasing usage OS functional material could help protect from environment antioxidant effects...