A5100409605- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Peroxisome Proliferator-Activated Receptors
- Cancer, Lipids, and Metabolism
- Pancreatic function and diabetes
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Cell Adhesion Molecules Research
- Regulation of Appetite and Obesity
- Cardiovascular Disease and Adiposity
- Angiogenesis and VEGF in Cancer
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Disease Diagnosis and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Protease and Inhibitor Mechanisms
- NF-κB Signaling Pathways
- Signaling Pathways in Disease
- Neural dynamics and brain function
- Cervical Cancer and HPV Research
- Immune Cell Function and Interaction
- Diabetes Management and Research
- Alzheimer's disease research and treatments
Hallym University Sacred Heart Hospital
2025
Hallym University
2010-2025
Ulsan National Institute of Science and Technology
2014-2024
Chungnam National University
2024
Gwangju Institute of Science and Technology
2020-2023
Florida State University
2022-2023
Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde
2023
Witten/Herdecke University
2023
Harvard University
2018-2022
The University of Texas Southwestern Medical Center
2010-2022
Adipocytes represent a major cell type in the mammary tumor microenvironment and are important for growth. Collagen VI (COL6) is highly expressed adipose tissue, upregulated obese state, enriched breast cancer lesions stimulator of Here, we have described cleavage product COL6α3 chain, endotrophin (ETP), which serves as mediator COL6-mediated effects. ETP augmented fibrosis, angiogenesis, inflammation through recruitment macrophages endothelial cells. Moreover, expression was associated with...
AbstractGlucose-6-phosphate dehydrogenase (G6PD) produces cellular NADPH, which is required for the biosynthesis of fatty acids and cholesterol. Although G6PD lipogenesis, it poorly understood whether in adipocytes involved energy homeostasis, such as lipid glucose metabolism. We report here that plays a role adipogenesis its increase tightly associated with dysregulation metabolism insulin resistance obesity. observed enzymatic activity expression levels were significantly elevated white...
Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme that regulates cellular redox potential. In this study, we demonstrate macrophage G6PD plays an important role in the modulation of proinflammatory responses and oxidative stress. The levels macrophages adipose tissue obese animals were elevated, mRNA positively correlated with those genes. Lipopolysaccharide (LPS) free fatty acids, which initiate signals, stimulated G6PD. Overexpression potentiated expression pro-oxidative genes...
Expression of anger is associated with biological health risk (BHR) in Western cultures. However, recent evidence documenting culturally divergent functions the expression suggests that its link BHR may be moderated by culture. To test this prediction, we examined large probability samples both Japanese and Americans using multiple measures BHR, including pro-inflammatory markers (interleukin-6 C-reactive protein) indices cardiovascular malfunction (systolic blood pressure ratio total to HDL...
The extracellular matrix (ECM) plays an important role in the maintenance of white adipose tissue (WAT) architecture and function, proper ECM remodeling is critical to support WAT malleability accommodate changes energy storage needs. Obesity adipocyte hypertrophy place a strain on machinery, which may promote disordered altered integrity could proinflammatory cell stress signals. To explore these questions, new methods were developed quantify omental subcutaneous tensile strength collagen...
Blocking phosphorylation of peroxisome proliferator-activated receptor (PPAR)γ at Ser(273) is one the key mechanisms for antidiabetes drugs to target PPARγ. Using high-throughput screening, we here describe that Gleevec blocks cyclin-dependent kinase 5-mediated PPARγ devoid classical agonism as a antagonist ligand. In high fat-fed mice, improved insulin sensitivity without causing severe side effects associated with other PPARγ-targeting drugs. Furthermore, reduces lipogenic and...
PERIOD (PER) and Casein Kinase 1δ regulate circadian rhythms through a phosphoswitch that controls PER stability repressive activity in the molecular clock. CK1δ phosphorylation of familial advanced sleep phase (FASP) serine cluster embedded within 1 binding domain (CK1BD) mammalian PER1/2 inhibits its on phosphodegrons to stabilize extend period. Here, we show phosphorylated FASP region (pFASP) PER2 directly interacts with CK1δ. Co-crystal structures conjunction dynamics simulations reveal...
In adipocytes, oxidative stress and chronic inflammation are closely associated with metabolic disorders, including insulin resistance, obesity, cardiovascular disease, type 2 diabetes. However, the molecular mechanisms underlying these disorders have not been thoroughly elucidated. this report, we demonstrate that overexpression of glucose-6-phosphate dehydrogenase (G6PD) in adipocytes stimulates inflammatory responses, thus affecting neighboring macrophages. Adipogenic G6PD promotes...
Adiponectin is exclusively expressed in differentiated adipocytes and plays an important role regulating energy homeostasis, including the glucose lipid metabolism associated with increased insulin sensitivity. However, control of adiponectin gene expression poorly understood. We show here that levels mRNA protein are reduced white adipose tissue ob/ob db/db mice there a concomitant reduction adipocyte determination- differentiation-dependent factor 1 (ADD1)/sterol regulatory element-binding...
Liver steatosis was caused by lipid accumulation in the liver. Alisma orientale (AO) is recognized as a promising candidate with therapeutic efficacy for treatment of nonalcoholic fatty liver disease (NAFLD). HepG2 hepatocyte cell line commonly used model. The cells were cultured NEFAs mixture (oleic and palmitic acids, 2:1 ratio) 24 h to induce hepatic steatosis. Then different doses extract (AOE) treated h. Incubated further experiments. AOE showed inhibitory effects on Oil Red O staining...
Pyramidal neurons integrate synaptic inputs from basal and apical dendrites to generate stimulus-specific responses. It has been proposed that feed-forward drive a neuron's stimulus preference, while feedback sharpen selectivity. However, how dendritic domains relate its functional selectivity not demonstrated experimentally. We performed 2-photon micro-dissection on layer-2/3 pyramidal in mouse primary visual cortex. found removing the tuft did alter orientation-tuning. Furthermore,...
Glucose hypometabolism in cortical structures after functional disconnection is frequently reported patients with white matter diseases such as subcortical stroke. However, the molecular and cellular mechanisms have been poorly elucidated. Here we show, an animal model of internal capsular infarct, that GABA-synthesizing reactive astrocytes distant areas cause glucose via tonic inhibition neighboring neurons. We find reversal aberrant astrocytic GABA synthesis, by pharmacological...
We have previously reported that the carboxy-terminal proteolytic cleavage product of COL6α3 chain we refer to as "endotrophin" has potent effects on transformed mammary ductal epithelial cells in rodents. Endotrophin (ETP) is abundantly expressed adipose tissue. It a chemoattractant for macrophages, exerts endothelial and through epithelial-mesenchymal transition (EMT) enhances progression tumor cells. In recombinant form, human endotrophin similar macrophages its rodent counterpart. EMT...
Liver X receptor (LXR)α and LXRβ play important roles in fatty acid metabolism cholesterol homeostasis. Although the functional of LXR liver, intestine, fat, macrophages are well established, its role pancreatic β-cells has not been clearly defined. In this study, we revealed that chronic activation contributes to lipotoxicity-induced β-cell dysfunction. We observed significantly elevated expression islets diabetic rodent models, including fa/fa ZDF rats, OLETF db/db mice. primary INS-1...