John Varga
A5012966437- Systemic Sclerosis and Related Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Dermatologic Treatments and Research
- Inflammatory Myopathies and Dermatomyositis
- Connective Tissue Growth Factor Research
- Mast cells and histamine
- Eosinophilic Disorders and Syndromes
- TGF-β signaling in diseases
- Wnt/β-catenin signaling in development and cancer
- Skin and Cellular Biology Research
- Fibroblast Growth Factor Research
- Eosinophilic Esophagitis
- Autoimmune Bullous Skin Diseases
- Dermatological and Skeletal Disorders
- Pulmonary Hypertension Research and Treatments
- Dupuytren's Contracture and Treatments
- Medical Imaging and Pathology Studies
- Skin Diseases and Diabetes
- Cell Adhesion Molecules Research
- Kruppel-like factors research
- Cytokine Signaling Pathways and Interactions
- Chronic Myeloid Leukemia Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- IL-33, ST2, and ILC Pathways
- Amyloidosis: Diagnosis, Treatment, Outcomes
University of Michigan
2018-2025
Northwestern University
2013-2024
Scleroderma Foundation
2016-2024
Michigan United
2022-2024
Michigan Medicine
2022-2024
Center for Rheumatology
2007-2022
University of Toronto
2021
Northwestern University
2020
Yale University
2019-2020
University of California, Los Angeles
2001-2019
We conducted a double-blind, randomized, placebo-controlled trial to determine the effects of oral cyclophosphamide on lung function and health-related symptoms in patients with evidence active alveolitis scleroderma-related interstitial disease.At 13 clinical centers throughout United States, we enrolled 158 scleroderma, restrictive physiology, dyspnea, inflammatory disease examination bronchoalveolar-lavage fluid, thoracic high-resolution computed tomography, or both. Patients received (<...
It has been previously shown that transforming growth factor beta (TGF beta) is capable of stimulating fibroblast collagen and fibronectin biosynthesis. The purpose this study was to examine the mechanisms involved in TGF stimulation biosynthetic activity. Our results indicate causes a marked enhancement production types I III collagens by cultured normal human dermal fibroblasts. rate fibroblasts exposed 2-3-fold greater than control cells. These effects were associated with increase...
The Scleroderma Lung Study enrolled 158 patients with scleroderma-related interstitial lung disease in a placebo-controlled trial of oral cyclophosphamide (CYC). Although treatment-related benefits pulmonary function, skin scores, and patient-centered outcomes were demonstrated after 1 year therapy, the duration benefit beyond was unclear.A second follow-up performed to determine if these effects persisted stopping treatment.A detailed analysis data obtained over two years study...
Systemic sclerosis (SSc) is a complex disease characterized by early microvascular abnormalities, immune dysregulation and chronic inflammation, subsequent fibrosis of the skin internal organs. Excessive fibrosis, distinguishing hallmark SSc, end result series interlinked vascular injury activation, represents maladaptive repair process. Activated vascular, epithelial, cells generate pro-fibrotic cytokines, chemokines, growth factors, lipid mediators, autoantibodies, reactive oxygen species....
Abstract The factors responsible for maintaining persistent organ fibrosis in systemic sclerosis (SSc) are not known but emerging evidence implicates toll-like receptors (TLRs) the pathogenesis of SSc. Here we show expression, mechanism action and pathogenic role endogenous TLR activators skin from patients with SSc, fibroblasts, mouse models fibrosis. Levels tenascin-C elevated SSc biopsy samples, serum fibrotic tissues mice. Exogenous stimulates collagen gene expression myofibroblast...
Because recent studies implicate Toll-like receptors (TLRs) in the pathogenesis of fibrosis, we sought to investigate vitro and vivo role mechanism TLR4-mediated fibroblast responses fibrogenesis. We found that TLR4 was constitutively expressed, accumulation endogenous ligands significantly elevated, lesional skin lung tissues from patients with scleroderma. Activation signaling explanted fibroblasts resulted enhanced collagen synthesis increased expression multiple genes involved tissue...
Fibronectin EDA is an endogenous TLR4 ligand in scleroderma.
Section:ChooseTop of pageAbstract <<PathogenesisGenetics and EpigeneticsRisk Factors for the Deve...Blood Serum BAL Fluid...Comparison with IPFConclusionsReferencesCITING ARTICLES
We provide evidence-based recommendations regarding the treatment of interstitial lung disease (ILD) in adults with systemic autoimmune rheumatic diseases (SARDs).
Objective We provide evidence‐based recommendations regarding screening for interstitial lung disease (ILD) and the monitoring ILD progression in people with systemic autoimmune rheumatic diseases (SARDs), specifically rheumatoid arthritis, sclerosis, idiopathic inflammatory myopathies, mixed connective tissue disease, Sjögren disease. Methods developed clinically relevant population, intervention, comparator, outcomes questions related to patients SARDs. A systematic literature review was...
Abstract Systemic sclerosis (SSc) is a devastating autoimmune disease characterized by excessive production and accumulation of extracellular matrix, leading to fibrosis skin other internal organs. However, the main cellular participants in SSc remain incompletely understood. Here using differentiation trajectories at single cell level, we demonstrate dual source matrix deposition from both myofibroblasts endothelial-to-mesenchymal-transitioning cells (EndoMT). We further define central role...
Objective We provide evidence‐based recommendations regarding screening for interstitial lung disease (ILD) and the monitoring ILD progression in people with systemic autoimmune rheumatic diseases (SARDs), specifically rheumatoid arthritis, sclerosis, idiopathic inflammatory myopathies, mixed connective tissue disease, Sjögren disease. Methods developed clinically relevant population, intervention, comparator, outcomes questions related to patients SARDs. A systematic literature review was...
Objective To test the hypothesis that systemic sclerosis (SSc) patients taking high-dose D-penicillamine (D-Pen) would have greater softening of skin, lower frequency renal crisis, and better survival than low-dose D-Pen. Methods Seventeen centers enrolled 134 SSc with early (≤18 months) diffuse cutaneous scleroderma into a 2-year, double-blind, randomized comparison D-Pen (750–1,000 mg/day) versus (125 mg every other day). All were followed up for mean ± SD 4.0 1.1 years to assess...