A5100688152- Glioma Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Meningioma and schwannoma management
- Hematological disorders and diagnostics
- Radiopharmaceutical Chemistry and Applications
- Cancer Research and Treatments
- Elasticity and Material Modeling
- Medical Research and Treatments
- Nerve injury and regeneration
- Ultrasound Imaging and Elastography
- Ovarian cancer diagnosis and treatment
- Cardiac electrophysiology and arrhythmias
- Histone Deacetylase Inhibitors Research
- Drug Transport and Resistance Mechanisms
- Dupuytren's Contracture and Treatments
- Pharmacogenetics and Drug Metabolism
- Viral-associated cancers and disorders
- Inflammatory Myopathies and Dermatomyositis
- Sarcoma Diagnosis and Treatment
- Vascular Malformations and Hemangiomas
- Antifungal resistance and susceptibility
- Dermatologic Treatments and Research
- Oral microbiology and periodontitis research
- Histiocytic Disorders and Treatments
Second Affiliated Hospital of Zhejiang University
2011-2025
Northwestern University
2014-2025
Neurological Surgery
2021-2025
Taiyuan Central Hospital
2020-2024
Northwestern University
2024
Jilin University
2024
Peking University
2024
Sun Yat-sen University
2023-2024
Fuling Center Hospital of Chongqing
2024
Chongqing University
2024
Abstract The factors responsible for maintaining persistent organ fibrosis in systemic sclerosis (SSc) are not known but emerging evidence implicates toll-like receptors (TLRs) the pathogenesis of SSc. Here we show expression, mechanism action and pathogenic role endogenous TLR activators skin from patients with SSc, fibroblasts, mouse models fibrosis. Levels tenascin-C elevated SSc biopsy samples, serum fibrotic tissues mice. Exogenous stimulates collagen gene expression myofibroblast...
Fibronectin EDA is an endogenous TLR4 ligand in scleroderma.
Background Pancreatic cancer remains an extremely malignant digestive tract tumor, posing a significant global public health burden. Patients with pancreatic cancer, once metastasis occurs, lose all hope of cure, and prognosis is poor. It important to investigate liver in depth, not just because it the most common form but also crucial for treatment planning assessment. This study aims delve into mechanisms metastasis, goal providing scientific groundwork development future methods drugs....
Persistent fibrosis in multiple organs is the hallmark of systemic sclerosis (SSc). Recent genetic and genomic studies implicate TLRs their damage-associated molecular pattern (DAMP) endogenous ligands fibrosis. To test hypothesis that TLR4 its coreceptor myeloid differentiation 2 (MD2) drive persistence, we measured MD2/TLR4 signaling tissues from patients with fibrotic SSc, examined impact MD2 targeting using a potentially novel small molecule. Levels TLR4, TLR4-responsive gene signature,...
Rationale: Fibrosis leads to failure of the skin, lungs, and other organs in systemic sclerosis; accounts for substantial morbidity mortality; lacks effective therapy. Myofibroblast activation underlies organ fibrosis, but key extracellular cues driving persistence process remain incompletely characterized. Objectives: The objectives were evaluate IL6/JAK/STAT axis associated with fibrosis skin lung biopsies from sclerosis patients effects Food Drug Administration–approved JAK/STAT...
Seizures are a frequent complication of adult-type diffuse gliomas, and often difficult to control with medications. Gliomas mutations in isocitrate dehydrogenase 1 or 2 (IDHmut) more likely than IDH–wild type (IDHwt) gliomas cause seizures as part their initial clinical presentation. However, whether IDHmut is also associated during the remaining disease course, inhibitors can reduce seizure risk, unclear. Clinical multivariable analyses showed that preoperative seizures, glioma location,...
Abstract Background Antenatal depression (AD) is a major depressive disorder during pregnancy, which may lead to devastating sequelae for the expectant mothers and infants. This study aimed investigate prevalence, analyze trajectory model based on EPDS score , explore influence factors of AD among pregnant women in Chengdu, China. Methods Participants from four maternity hospitals China were recruited when they had their first pregnancy medical check-up March 2019 May 2020. All participants...
Although transforming growth factor β (TGFβ) is recognized as being a key trigger of fibroblast activation in systemic sclerosis (SSc), prominent innate immunity suggests that additional pathways contribute to disease persistence. Toll-like receptor 9 (TLR9) implicated autoimmunity and fibrosis; however, the expression, mechanism action, pathogenic role TLR9 signaling SSc remain uncharacterized. The aim this study was explore activity, potential context skin fibrosis mouse models...
Systemic sclerosis (SSc) is a poorly understood heterogeneous condition with progressive multi-organ fibrosis. Recent genetic and genomic evidence suggest pathogenic role for dysregulated innate immunity toll-like receptor (TLR) activity in SSc. Levels of both TLR4, as well certain endogenous TLR ligands, are elevated skin lung tissues from patients SSc correlate clinical disease parameters. Conversely, targeting TLR4 or its "damage-associated" ligands ameliorates tissue Targeting signaling...
BACKGROUND:The restoration of damaged periodontium, especially one-wall intrabony defects, is a major challenge for clinicians. Concentrated growth factors (CGF) are 100% autologous fibrin with multiple concentrated factors. The rigid structure CGF makes it possible to preserve or reconstruct the initial bone volume. aim this study was evaluate clinical healing patterns after surgical application and without Bio-Oss graft in infrabony defects. MATERIAL AND METHODS:We randomly divided 120...
Rac GTPase activating protein 1 (RacGAP1) can regulate cytokinesis and cell differentiation. The oncogenic role of RacGAP1 has been partially studied in gastric cancer, colorectal breast cancer. In the present study, we endeavor to evaluate its expression functions epithelial ovarian cancer (EOC). We retrospectively collected clinicopathological information 117 patients who underwent curative surgery for EOC. Expression primary tumor tissues was evaluated by immunohistochemistry, which...
The ubiquitin-editing cytosolic enzyme A20, the major negative regulator of toll-like receptor (TLR)-mediated cellular inflammatory responses, has tight genetic linkage with systemic sclerosis (SSc). Because recent studies implicate endogenous ligand-driven TLR signaling in SSc pathogenesis, we sought to investigate regulation, role and mechanism action A20 skin fibroblasts. expression effects forced or siRNA-mediated knockdown on fibrotic responses induced by transforming growth factor-ß...
Abstract Purpose To investigate the value of 18 F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography ( F-FDG PET/CT) in differential diagnosis lymphoma patients with fever unknown origin (FUO) accompanied by lymphadenopathy and to develop a simple scoring system distinguish from other etiologies. Methods A prospective study was conducted on classic FUO lymphadenopathy. After standard diagnostic procedures, including PET/CT scan lymph-node biopsy, 163 were enrolled...
The gene F3, encoding Tissue Factor (TF), is expressed in many cancers and contributes to their malignancy. Among adult-type diffuse gliomas, IDH1/2 wild-type (IDHwt) glioblastomas (GBM) express more TF than mutant (IDHmut) gliomas. Tisotumab vedotin (TisVed), an anti-TF antibody conjugated monomethyl auristatin E, a therapeutic designed target cells expressing TF. We therefore sought determine the potential of TisVed IDHwt vs. IDHmut treated patient-derived glioma with control IgG,...
INTRODUCTION: Histologic findings are the primary determinant of meningioma prognosis and post-operative management. However, relationship specific pathologic features to molecular alterations has not yet been comprehensively investigated. METHODS: Detailed histological information was collected for 809 resected meningiomas, including cases with DNA methylation (n=380), copy number array (n=252), next-generation sequencing (n=52), RNA risk score (n=394), and/or TERT promoter profiling...
<title>Abstract</title> Purpose Papillary thyroid carcinoma (PTC) and Hashimoto's thyroiditis (HT) are diseases where one is a "cancer" that has escaped immune system surveillance, the other an "autoimmune disease" attacks body's own systems. They appear to be antagonistic in form, but reality, they can occur simultaneously. The similarities or differences their gene molecular expression worth in-depth discussion. Research Methods This study searched GEO database, integrating 4 datasets...
It was recently disclosed that CYP3A is responsible for the tertiary stereoselective oxidations of deoxycholic acid (DCA), which becomes a continuum mechanism host-gut microbial cometabolism bile acids (BAs) in humans. This work aims to investigate species differences BA redox metabolism and clarify whether DCA conserved pathway preclinical animals. With quantitative determination total unconjugated BAs urine fecal samples humans, dogs, rats, mice, it confirmed oxidized metabolites were...
Myeloid sarcoma (MS) is defined as a tumor mass consisting of myeloid blast with or without maturation occurring at an anatomical site other than bone marrow normal architectural effacement. It can also precede the onset leukemia which called non-leukemic MS. Non-leukemic MS kind rare disease and easy to be misdiagnosed common malignancies due rarity nonspecific manifestation. We herein report unusual case involving vulva, vagina, cervix in female patient. The aspiration biopsy patient...
Lung cancer is a malignant tumor leading to the most cancer-related deaths worldwide. The treatment efficiency of lung remains poor mainly due chemotherapy drug resistance, including cisplatin. MicroRNAs (miRNAs) are closely related resistance cells. Here, we illustrated underlying mechanism miR-1236-3p on DDP in In this study, found that expression level was significantly decreased tissues and A549 cell line. addition, half maximal inhibitory concentration (IC50) cells lower than A549/DDP...
Abstract The aim of this study was to assess whether physical activity can predict mortality in patients undergoing maintenance hemodialysis (MHD). This observational enrolled 317 MHD from Shanxi Provincial People Hospital and the Second Affiliated Xi'an Medical University February June 2012. Physical measured by using Human Activity Profile (HAP) Stanford 7‐day Recall Questionnaire (PAR). Exercise or not, maximal score (MAS), adjusted (AAS), light activities, moderate PAR value were...
To improve the diagnostic efficacy of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) for Chinese patients with fever unknown origin (FUO) and inflammation (IUO), combined clinical parameters.FUO/IUO who underwent a standard work-up 18F-FDG PET/CT scanning were enrolled divided into local uptake lesion subgroup non-specific abnormal subgroup. Beneficial parameters improving identified.From January 2014 to 2019, 253 FUO/IUO studied. In total, 147 had...
Systemic sclerosis (SSc) is a chronic, multisystem orphan disease with highly variable clinical course, high mortality rate, and poorly understood complex pathogenesis. We have identified an important role for subpopulation of monocytes macrophages characterized by surface expression the scavenger receptor macrophage collagenous structure (MARCO) in chronic inflammation fibrosis SSc preclinical models. show that MARCO+ accumulate lesional skin lung topographic proximity to activated...