A5100707556- Lung Cancer Research Studies
- RNA modifications and cancer
- Monoclonal and Polyclonal Antibodies Research
- Epigenetics and DNA Methylation
- Cell Adhesion Molecules Research
- Psoriasis: Treatment and Pathogenesis
- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Immunotherapy and Immune Responses
- Glycosylation and Glycoproteins Research
- Lung Cancer Treatments and Mutations
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ovarian cancer diagnosis and treatment
- Peptidase Inhibition and Analysis
- HER2/EGFR in Cancer Research
- Dermatology and Skin Diseases
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Cancer Immunotherapy and Biomarkers
- Dermatologic Treatments and Research
- S100 Proteins and Annexins
- Angiogenesis and VEGF in Cancer
- Cancer-related gene regulation
- Kruppel-like factors research
Brown Foundation
2013-2025
Dingxi City People's Hospital
2025
West Anhui University
2023-2024
Shanghai Sixth People's Hospital
2009-2024
The University of Texas Health Science Center at Houston
2012-2024
Shanghai Jiao Tong University
2011-2024
Beijing Shijitan Hospital
2017-2023
Capital Medical University
2017-2023
Guangzhou Medical University
2012-2023
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2023
Abstract Immune-related adverse events (irAEs), caused by anti-PD-1/PD-L1 antibodies, can lead to fulminant and even fatal consequences thus require early detection aggressive management. However, a comprehensive approach identify biomarkers of irAE is lacking. Here, we utilize strategy that combines pharmacovigilance data omics data, evaluate associations between multi-omics factors reporting odds ratio across different cancer types. We bivariate regression model LCP1 ADPGK accurately...
Epidermal growth factor receptor (EGFR) genotype is crucial for treatment decision making in lung cancer, but it can be affected by tumour heterogeneity and invasive biopsy during gene sequencing. Importantly, not all patients with an EGFR mutation have good prognosis EGFR-tyrosine kinase inhibitors (TKIs), indicating the necessity of stratifying EGFR-mutant genotype. In this study, we proposed a fully automated artificial intelligence system (FAIS) that mines whole-lung information from CT...
Trastuzumab has been used for the treatment of HER2-overexpressing breast cancer more than a decade, but mechanisms action therapy are still being actively investigated. Ab-dependent cell-mediated cytotoxicity mediated by NK cells is well recognized as one key trastuzumab, trastuzumab-mediated cellular phagocytosis (ADCP) not established. In this study, we demonstrate that macrophages, way phagocytic engulfment, can mediate ADCP and cell killing in presence trastuzumab. Increased...
Background Immune exclusion (IE) where tumors deter the infiltration of immune cells into tumor microenvironment has emerged as a key mechanism underlying immunotherapy resistance. We recently reported novel role discoidin domain-containing receptor 1 (DDR1) in promoting IE breast cancer and validated its critical using neutralizing rabbit monoclonal antibodies (mAbs) multiple mouse models. Methods To develop DDR1-targeting mAb potential therapeutic, we humanized mAb9 with...
Abstract Antiangiogenic treatment targeting the vascular endothelial growth factor (VEGF) pathway is a powerful tool to combat tumor and progression; however, drug resistance frequently emerges. We identify CD5L (CD5 antigen-like precursor) as an important gene upregulated in response antiangiogenic therapy leading emergence of adaptive resistance. By using both RNA-aptamer monoclonal antibody CD5L, we are able abate pro-angiogenic effects overexpression vitro vivo settings. In addition,...
We have previously reported that the carboxy-terminal proteolytic cleavage product of COL6α3 chain we refer to as "endotrophin" has potent effects on transformed mammary ductal epithelial cells in rodents. Endotrophin (ETP) is abundantly expressed adipose tissue. It a chemoattractant for macrophages, exerts endothelial and through epithelial-mesenchymal transition (EMT) enhances progression tumor cells. In recombinant form, human endotrophin similar macrophages its rodent counterpart. EMT...
Cholangiocarcinoma (CCA) and gallbladder carcinoma (GBC) are biliary tract cancers with poor five-year survival high recurrence rates. Both CCA GBC patients suffer from lack of circulating diagnostic biomarkers at the early stage. Extracellular vesicles, especially exosomes, have been emerged as promising sources for due to easy quick accessibility. Hence, identification exosomal provides a novel strategy diagnosis. Here, five four were enrolled small RNA sequencing. Our data showed that...
Abstract Although patients with advanced ovarian cancer may respond initially to treatment, disease relapse is common, and nearly 50% of do not survive beyond five years, indicating an urgent need for improved therapies. To identify new therapeutic targets, we performed single-cell nuclear RNA-seq data set analyses on 17 human specimens, revealing the oncostatin M receptor (OSMR) as highly expressed in cells. Conversely, (OSM), ligand OSMR, was by tumor-associated macrophages promoted...
Abstract One major limitation of neutralizing antibody-based COVID-19 therapy is the requirement costly cocktails to reduce emergence antibody resistance. Here we engineer two bispecific antibodies (bsAbs) using distinct designs and compared them with parental their cocktail. Single molecules both bsAbs block epitopes targeted by on receptor-binding domain (RBD). However, bsAb IgG-(scFv) 2 design (14-H-06) but not CrossMAb (14-crs-06) shows increased antigen-binding virus-neutralizing...
Carboxyl-terminal binding protein 1 (CtBP1) is a transcriptional co-repressor that represses expression of various tumor suppressor genes.In the present study, we identified miR-137 as potential regulator CtBP1 in melanoma cells.Expression cell lines was found to inversely correlate with levels.Target Scan predicted putative site for within 3′ untranslated region (3′UTR) at nt 710-716, which highly conserved across species.To explore mechanism targeting CtBP1, performed an Argonaute 2...
Abstract Introduction Trastuzumab has been widely used for the treatment of human epidermal growth factor receptor 2 (HER2) overexpressing breast cancer more than a decade. However, reports on involvement HER2 downregulation in trastuzumab’s mechanism action are inconsistent. The aim this study is to investigate if dependence trastuzumab-mediated cell immune effector cells represents novel trastuzumab. Methods expression was evaluated by Western blotting, flow cytometry, and real-time...
Recent studies reported that human IgG antibodies are susceptible to specific proteolytic cleavage in their lower hinge region, and the results a loss of Fc-mediated effector functions. Trastuzumab is humanized IgG1 therapeutic monoclonal antibody for treatment HER2-overexpressing breast cancers, its mechanisms action consist inhibition HER2 signaling antibody-dependent cellular cytotoxicity (ADCC). The objective this study investigate potential effect proteinase on efficacy trastuzumab...
Background: To analyze the venous thromboembolism (VTE) risk factors and prophylaxis of elderly patients in intensive care unit (ICU).
Abstract Carboxyl‐terminal binding protein 1 (CtBP1) is a transcriptional co‐repressor with oncogenic potential. Immunohistochemistry staining using human breast cancer tissue arrays revealed that 92% of invasive ductal cases have CtBP1‐positive compared to 4% in normal tissue. To explore the functional impact CtBP1 cancer, we examined CtBP1's regulation known tumor suppressors, susceptibility gene (Brca1), and E‐cadherin. We found was recruited promoter regions Brca1 E‐cadherin genes cells....
Angiogenesis inhibitors are important for cancer therapy, but clinically approved anti-angiogenic agents have shown only modest efficacy and can compromise wound healing. This necessitates the development of novel anti-angiogenesis therapies. Here, we show significantly increased EGFL6 expression in tumor versus or normal endothelial cells. Using a series vitro vivo studies with orthotopic genetically engineered mouse models, demonstrate mechanisms by which stimulates angiogenesis. In...
The prevalence of psoriasis is increasing, and poses a serious risk to human health quality life. Psoriasis, chronic immune‑mediated skin disease with epidermal hyperkeratosis parakeratosis, associated numerous complications, including metabolic syndromes that are regulated by sirtuins (SIRTs) via deacetylation. As they serve necessary function in inflammation metabolism, SIRTs considered link syndrome. Previous studies have indicated the pathophysiology psoriasis, but date no detailed...
With the application of immune checkpoint inhibitors (ICIs) in cancer treatment, more and attention has been paid to inhibitor-related pneumonitis (CIP), which requires a better understanding its clinical characteristics therapeutic effects.The imaging data 704 patients with non-small cell lung (NSCLC) who received immunotherapy were analyzed retrospectively; CIP summarized, regimens effects summarized.36 included research. The most common symptoms cough, shortness breath fever. CT...
Multiple myeloma (MM) remains incurable due to drug resistance. Ribosomal protein S3 (RPS3) has been identified as a non-Rel subunit of NF-κB. However, the detailed biological roles RPS3 remain unclear. Here, we report for first time that is necessary MM survival and was highly expressed in MM, knockout inhibited cell growth induced apoptosis both vitro vivo. Overexpression mediated proteasome inhibitor resistance delayed tumour-bearing animals. Moreover, our present study found an...