A5056431102- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Dendrimers and Hyperbranched Polymers
- Virus-based gene therapy research
- DNA and Nucleic Acid Chemistry
- Flowering Plant Growth and Cultivation
- Immune cells in cancer
- Electrospun Nanofibers in Biomedical Applications
- Immunotherapy and Immune Responses
- Tissue Engineering and Regenerative Medicine
- Heart Failure Treatment and Management
- Advanced Drug Delivery Systems
- Wound Healing and Treatments
- Advanced Glycation End Products research
- Healthcare Education and Workforce Issues
- Silk-based biomaterials and applications
- Epigenetics and DNA Methylation
- Neuroinflammation and Neurodegeneration Mechanisms
- Graphene and Nanomaterials Applications
- Health and Wellbeing Research
- Protein Degradation and Inhibitors
Chungnam National University
2020-2025
Korea Institute of Science and Technology
2015-2024
Korea University
2012-2024
Hanyang University Medical Center
2020-2022
Korea Maritime and Ocean University
2022
Anyang University
2017-2022
Chung-Ang University Hospital
2020-2022
Hanyang University
2014-2020
Gachon University
2020
National Research Foundation of Korea
2020
Macrophages (Mϕs) critically contribute to wound healing by coordinating inflammatory, proliferative, and angiogenic processes. A proper switch from proinflammatory M1 anti-inflammatory M2 dominant Mϕs accelerates the processes leading favorable wound-care outcomes. Herein, an exosome-guided cell reprogramming technique is proposed directly convert for effective management. The Mϕ-derived exosomes (M2-Exo) induce a complete conversion of in vitro. reprogrammed turn Arginase (M2-marker) iNOS...
Right on target: An in vivo tumor-targeting strategy using nanoparticles has been developed. unnatural sialic acid (green, see scheme) with azide groups is artificially generated the target site by metabolic glycoengineering. These then effectively enhance accumulation of tumor an bioorthogonal copper-free click reaction.
Abstract Macrophages (Mφs) are characterized by remarkable plasticity, an essential component of chronic inflammation. Thus, appropriate and timely transition from proinflammatory (M1) to anti‐inflammatory (M2) Mφs during wound healing is vital promoting resolution acute inflammation enhancing tissue repair. Herein, exosomes derived M2‐Mφs (M2‐Exos), which contain putative key regulators driving Mφ polarization, used as local microenvironmental cues induce reprogramming M1‐Mφs toward for...
Abstract Lipid nanoparticles (LNPs) exhibit remarkable mRNA delivery efficiency, yet their majority accumulate in the liver or spleen after injection. Tissue‐specific can be achieved through modulating LNP properties, such as tuning PEGylation varying lipid components systematically. In this paper, a streamlined method is used for incorporating tumor‐targeting peptides into LNPs; programmed death ligand 1 (PD‐L1) binding are conjugated to PEGylated lipids via copper‐free click reaction, and...
Poly(d,l-lactic-co-glycolic acid) (PLGA) nanoparticles with anionic surface charge were coated cationic di-block copolymer, poly(l-lysine)−poly(ethylene glycol)−folate (PLL−PEG−FOL) conjugate, for enhancing their site-specific intracellular delivery against folate receptor overexpressing cancer cells. The PLGA the conjugate characterized in terms of size, charge, and change composition by XPS. By employing flow cytometry method confocal image analysis, extent cellular uptake was...
Among various proinflammatory cytokines involved in the pathogenesis of rheumatoid arthritis (RA), tumor necrosis factor (TNF)-α plays a pivotal role release other and induction chronic inflammation. Even though siRNA has therapeutic potential, they have challenge to be delivered into target cells because their poor stability physiological fluids. Herein, we design nanocomplex polymerized (poly-siRNA) targeting TNF-α with thiolated glycol chitosan (tGC) polymers for treatment RA. Poly-siRNA...
Abstract Conventional chemotherapy is plagued with adverse side effects because cancer treatments are subject to numerous variations, most predominantly from drug resistance. Accordingly, multiple or multistage chemotherapeutic regimens often performed, combining two more drugs orthogonal and possibly synergistic mechanisms. In this respect, glycol chitosan (GC)-based nanoparticles (CNPs) serve as an effective platform vehicle that can encapsulate both chemotherapeutics siRNA achieve maximal...
Microglia are resident myeloid cells in the CNS that activated by infection, neuronal injury, and inflammation. Established BV2 microglial cell lines have been primary vitro models used to study neuroinflammation for more than a decade because they reduce requirement of continuously maintaining preparations animal experimentation models. However, doubt has recently raised regarding value as model system. We triplicate RNA sequencing (RNA-seq) investigate molecular signature using two...
In the past few years, there have been many efforts underway to develop effective wound healing treatments for traumatic injuries. particular, wound-healing peptides (WHPs) and peptide-grafted dressings hold great promise novel therapeutic strategies management. This study reports a topical formulation of new synthetic WHP (REGRT, REG) embedded in hyaluronic acid (HA)-based hydrogel dressing enhancement acute excisional repair. The copper-free click chemistry is utilized form biocompatible...
In this study, we examined the potentially beneficial effects of bovine colostrum-derived exosomes on UV-induced aging and damage in three major resident skin cells including keratinocytes, melanocytes, fibroblasts. The treatment with colostrum prevented generation intracellular reactive oxygen species epidermal keratinocytes. UV-stimulated could also significantly reduce production protective skin-darkening pigment melanin, which may help to risk excessive melanin formation causing...
Human hair dermal papillary (DP) cells comprising mesenchymal stem in follicles contribute critically to growth and cycle regulation. The transition of from telogen anagen phase is the key regulating growth, which relies heavily on activation DP cells. In this paper, we suggested exosomes derived bovine colostrum (milk exosomes, Milk-exo) as a new effective non-surgical therapy for loss. Results showed that Milk-exo promoted proliferation rescued dihydrotestosterone (DHT, androgen...
Abstract While proteolysis‐targeting chimeras (PROTACs) hold great potential for persistently reprogramming the immunosuppressive tumor microenvironment via targeted protein degradation, precisely activating them in tissues and preventing uncontrolled proteolysis at off‐target sites remain challenging. Herein, a light‐triggered PROTAC nanoassembly (LPN) photodynamic indoleamine 2,3‐dioxygenase (IDO) is reported. The LPN derived from self‐assembly of prodrug conjugates, which comprise PROTAC,...