A5025495357- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Photoacoustic and Ultrasonic Imaging
- Advanced biosensing and bioanalysis techniques
- Extracellular vesicles in disease
- Ultrasound and Hyperthermia Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Immunotherapy and Immune Responses
- Advanced Nanomaterials in Catalysis
- Nanocluster Synthesis and Applications
- Photodynamic Therapy Research Studies
- RNA Interference and Gene Delivery
- Thermography and Photoacoustic Techniques
- Acute Ischemic Stroke Management
- Graphene and Nanomaterials Applications
- Molecular Sensors and Ion Detection
- Bone Tissue Engineering Materials
- Blood Coagulation and Thrombosis Mechanisms
- Protease and Inhibitor Mechanisms
- Ubiquitin and proteasome pathways
- Laser-Ablation Synthesis of Nanoparticles
- Nanoparticles: synthesis and applications
- Glycosylation and Glycoproteins Research
- Biochemical and Molecular Research
- Supramolecular Self-Assembly in Materials
Korea Institute of Science and Technology
2010-2024
Seoul Institute
2021
Biomedical Research Institute
2021
Government of the Republic of Korea
2021
Georgia Institute of Technology
2017-2019
Emory University
2018-2019
AID Atlanta
2019
The Wallace H. Coulter Department of Biomedical Engineering
2017-2019
National Institute of Biomedical Imaging and Bioengineering
2010
National Institutes of Health
2010
Nanodiagnosis: A matrix-metalloproteinase (MMP) sensitive gold-nanoparticle (AuNP) imaging probe quenches conjugated near-infrared (NIR) dyes with high efficiency and is specifically activated by the target MMPs (see picture, left). With this system, nanomolar amounts of protease can be detected—both in vitro vivo. Experiments disclose an apparent positive contrast MMPs-positive tumor-bearing mice (right). Supporting information for article available on WWW under...
Gold nanoprobe: Heparin–DOPA-coated gold nanoparticles (HEPA–AuNPs) showed low toxicity, prolonged stability, and an enhanced X-ray absorption coefficient in vitro. In vivo microCT images that HEPA–AuNPs produced liver-specific CT compared with iodine-based contrast agents, thus highlighting its potential as a novel, imaging agent (see figure).
Double spotlight: A dual imaging probe with gold nanoparticles (AuNPs) for computed tomography (CT) and optical exhibits have been developed (see picture). The excellent stability, tumor targeting ability, enhanced X-ray absorption, matrix metalloproteinase (MMP) activatable fluorescence recovery was achieved by surface modification of AuNPs glycol chitosan fluorescent MMP peptide probes. Detailed facts importance to specialist readers are published as "Supporting Information". Such...
Computed tomography (CT) is the current standard for time-critical decision-making in stroke patients, informing decisions on thrombolytic therapy with tissue plasminogen activator (tPA), which has a narrow therapeutic index. We aimed to develop CT-based method directly visualize cerebrovascular thrombi and guide therapy. Glycol-chitosan-coated gold nanoparticles (GC-AuNPs) were synthesized conjugated fibrin-targeting peptides, forming fib-GC-AuNP. This targeted imaging agent non-targeted...
Herein, we developed matrix metalloprotease (MMP) sensitive gold nanorods (MMP-AuNR) for cancer imaging and therapy. It was feasible to absorb NIR laser convert into heat as well visualize MMP activity. We showed the possibility of a hyperthermal therapeutic agent both in vitro vivo condition. The results suggested potential application MMP-AuNR simultaneous diagnosis
Nanodiagnose: Eine Goldnanopartikel(AuNP)-Bildgebungssonde für Matrixmetalloproteinasen (MMPs) löscht hoch effizient die Fluoreszenz konjugierter NIR-Farbstoffe und wird durch Ziel-MMPs spezifisch aktiviert (linker Bildteil). Das System detektiert nanomolare Proteasemengen in vitro ebenso wie vivo. Experimente belegen einen Kontrast im Tumormausmodell (rechts).
We developed a new apoptosis imaging probe with gold nanoparticles (AuNPs). A near-infrared fluorescence dye was attached to AuNP surface through the bridge of peptide substrate (DEVD). The quenched in physiological conditions due quenching effect AuNP, and recovered after DEVD had been cleaved by caspase-3, enzyme involved apoptotic process. adhesion substrates on accomplished conjugation 3,4-dihydroxy phenylalanine (DOPA) groups which are adhesive inorganic rich mussels. This modification...
Utility of glycol-chitosan-coated gold nanoparticles (GC-AuNPs) as a photoacoustic contrast agent for cancer cell imaging was demonstrated. Through the synergistic effect glycol chitosan and nanoparticles, GC-AuNPs showed cellular uptake in breast cells resulted strong signals tissue-mimicking phantoms. The performance agents established with confirmed dark-field microscopy. phantoms displayed if were incubated more than 3 h GC-AuNPs, compared PEG-AuNPs that no signal increase. enhanced...
Objective Advancing the understanding and management of thromboembolic stroke requires simple robust new methods that would be useful for in vivo assessment thrombus burden/distribution characterizing its evolution a prompt quantitative manner. Methods Animals (n=127) with experimental models thrombosis were imaged microcomputed tomography 5 minutes (and/or ∼3 weeks) after intravenous injection glycol chitosan (GC) gold nanoparticles (AuNPs). Results Nanoparticles accumulated thrombus,...