A5064534768- Pluripotent Stem Cells Research
- 3D Printing in Biomedical Research
- CRISPR and Genetic Engineering
- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- RNA Interference and Gene Delivery
- Photoacoustic and Ultrasonic Imaging
- Neuroscience and Neural Engineering
- Advanced biosensing and bioanalysis techniques
- Asymmetric Synthesis and Catalysis
- Cancer-related Molecular Pathways
- Chemical Synthesis and Analysis
- Renal and related cancers
- Thermography and Photoacoustic Techniques
- Bone Tissue Engineering Materials
- Inorganic and Organometallic Chemistry
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Plasma Diagnostics and Applications
- ZnO doping and properties
- Angiogenesis and VEGF in Cancer
- Wound Healing and Treatments
- Congenital heart defects research
- Analytical Chemistry and Chromatography
- Advanced Glycation End Products research
Io Therapeutics (United States)
2025
Chung-Ang University
2022-2025
Kyungpook National University
2007-2023
Konkuk University
2013-2022
Columbia University
2012-2022
Cell Biotech (South Korea)
2012-2022
Catholic Kwandong University
2022
Seoul National University of Education
2022
Bio-Medical Science (South Korea)
2019-2022
Sangji University
2022
Inherited and somatic mutations in the adenomatous polyposis coli occur most colon cancers, leading to activation of β-catenin-responsive genes. To identify small molecule antagonists this pathway, we challenged transformed colorectal cells with a secondary structure-templated chemical library, looking for compounds that inhibit reporter. We identified ICG-001, down-regulates β-catenin/T cell factor signaling by specifically binding cyclic AMP response element-binding protein. ICG-001...
Current hyaluronic acid (HA) hydrogel systems often cause cytotoxicity to encapsulated cells and lack the adhesive property required for effective localization of transplanted in vivo. In addition, injection into certain organs (e.g., liver, heart) induces tissue damage hemorrhage. this study, we describe a bioinspired, tissue‐adhesive that overcomes limitations current HA hydrogels through its improved biocompatibility potential minimally invasive cell transplantation. functionalized with...
The future of safe cell-based therapy rests on overcoming teratoma/tumor formation, in particular when using human pluripotent stem cells (hPSCs), such as embryonic (hESCs) and induced (hiPSCs). Because the presence a few remaining undifferentiated hPSCs can cause undesirable teratomas after transplantation, complete removal these with no/minimal damage to differentiated is prerequisite for clinical application hPSC-based therapy. Having identified unique hESC signature pro- antiapoptotic...
MDM2 and MDMX, negative regulators of the tumor suppressor p53, can work separately as a heteromeric complex to restrain p53's functions. also has pro-oncogenic roles in cells, tissues, animals that are independent p53. There is less information available about p53-independent MDMX or MDM2–MDMX complex. We found facilitate ferroptosis cells with without Using small molecules, RNA interference reagents, mutant forms we likely working part complex, normally ferroptotic death. observed alter...
Abstract Since both myocardium and vasculature in the heart are excessively damaged following myocardial infarction (MI), therapeutic strategies for treating MI hearts should concurrently target so as to achieve true cardiac repair. Here we demonstrate a concomitant method that exploits advantages of cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) mesenchymal cell-loaded patch (hMSC-PA) amplify repair rat model. Epicardially implanted hMSC-PA provide...
We established an efficient preparation method to obtain endothelial-like cells (ECs) from human embryonic stem (hESCs) and tested whether these hESC-ECs would show therapeutic potential for treatment of hindlimb ischemia.ECs differentiated hESCs were obtained by mechanical isolation cell sorting von Willebrand factor. The isolated maintained endothelial cell-specific characteristics such as marker expression capillary formation. One day after surgical induction ischemia in athymic mice,...
Epidermal electronics are extensively explored as an important platform for future biomedical engineering. devices typically fabricated using high‐cost methods employing complex vacuum microfabrication processes, limiting their widespread potential in wearable electronics. Here, a low‐cost, solution‐based approach electroconductive reduced graphene oxide (RGO) sheets on elastic and porous poly(dimethylsiloxane) (PDMS) thin films multifunctional, high‐performance, graphene‐based epidermal...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganic Chemistry of Ferrocene. I. The Acetylation Dialkylferrocenes1Kenneth L. Rinehart Jr., Kaye Motz, and Sung MoonCite this: J. Am. Chem. Soc. 1957, 79, 11, 2749–2754Publication Date (Print):June 1, 1957Publication History Published online1 May 2002Published inissue 1 June 1957https://pubs.acs.org/doi/10.1021/ja01568a023https://doi.org/10.1021/ja01568a023research-articleACS PublicationsRequest reuse permissionsArticle...
Medulloblastoma is the most common malignant brain tumor of childhood. Despite numerous advances, clinical challenges range from recurrent and progressive disease to long-term toxicities in survivors. The lack more effective, less toxic therapies results our limited understanding medulloblastoma growth. Although TP53 commonly altered gene cancers, it rarely mutated medulloblastoma. Accumulating evidence, however, indicates that pathways are disrupted Wild-type p53-induced phosphatase 1 (WIP1...
Abstract This paper reports a Si‐Ti‐Ni ternary alloy developed for commercial application as an anode material lithium ion batteries. Our exhibits stable capacity above 900 mAh g −1 after 50 cycles and high coulombic efficiency of up to 99.7% during cycling. To enable highly reversible nano‐Si anode, melt spinning is employed embed particles in Ti 4 Ni Si 7 matrix. The matrix fulfills two important purposes. First, it reduces the maximum stress evolved by applying compressive mechanically...
In response to DNA double strand breaks, the histone variant H2AX at break site is phosphorylated serine 139 by damage sensor kinases such as ataxia telangiectasia-mutated, forming gamma-H2AX. This phosphorylation event critical for sustained recruitment of other proteins repair break. After repair, restoration cell a prestress state associated with gamma-H2AX dephosphorylation and dissolution gamma-H2AX-associated foci. The phosphatases PP2A PP4 have previously been shown dephosphorylate...
An optically controlled energy-harvesting smart window that incorporates a semitransparent solar cell with photosensitive liquid crystal (LC) layer is demonstrated. The LC can switch between transparent (day mode) and an opaque (night state depending upon the incident radiation. Combined photovoltaic cell, this provides template for future systems.
Printable, wide band-gap chalcopyrite compound films (CuInGaS2, CIGS) were synthesized on transparent conducting oxide substrates. The and defective nature of the reveal semi-transparent bifacial properties that are beneficial for power generating window applications. Importantly, solar cell devices with these demonstrate a synergistic effect illumination resulting in 5.4–16.3% increase apparent conversion efficiency compared to simple sum efficiencies front rear side only. We also confirmed...
Abstract Release of human lung mast cell tryptase may be important in the pathophysiology asthma. We examined effect reversible, nonelectrophilic inhibitor MOL 6131 on airway inflammation and hyper-reactivity a murine model is potent selective nonpeptide based upon β-strand template (Ki = 45 nM) that does not inhibit trypsin 1,061 nM), thrombin 23, 640 or other serine proteases. BALB/c mice after i.p. OVA sensitization (day 0) were challenged intratracheally with days 8, 15, 18, 21. 6131,...