A5023826340- Bone Tissue Engineering Materials
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Graphene and Nanomaterials Applications
- Silk-based biomaterials and applications
- Periodontal Regeneration and Treatments
- Additive Manufacturing and 3D Printing Technologies
- Nanoparticle-Based Drug Delivery
- Hydrogels: synthesis, properties, applications
- Tissue Engineering and Regenerative Medicine
- Nerve injury and regeneration
- Spinal Cord Injury Research
- Vitamin D Research Studies
- Pancreatic function and diabetes
- Carbon and Quantum Dots Applications
- Nanoplatforms for cancer theranostics
- Dental Implant Techniques and Outcomes
- Otitis Media and Relapsing Polychondritis
- Polymer Surface Interaction Studies
- Pluripotent Stem Cells Research
- Immunodeficiency and Autoimmune Disorders
- Dental Radiography and Imaging
- Liver physiology and pathology
- Skin Protection and Aging
- Scientific and Engineering Research Topics
Brigham and Women's Hospital
2023-2025
Harvard University
2023-2025
Massachusetts General Hospital
2024-2025
Kyung Hee University
2017-2024
University of Dental Medicine
2018
Seoul National University Hospital
2018
Korea University
2013-2017
For effective bone regeneration, it is necessary to implant a biocompatible scaffold that capable of inducing cell growth and continuous osteogenic stimulation at the defected site. Here, we suggest an injectable hydrogel system using enzymatic cross-linkable gelatin (Gel) functionalized gold nanoparticles (GNPs).In this work, tyramine (Ty) was synthesized on backbone (Gel-Ty) enable phenol crosslinking reaction with horseradish peroxidase (HRP). N-acetyl cysteine (NAC) attached GNPs surface...
The engineered three-dimensional (3D) cell cultivation system for the production of multicellular spheroids has attracted considerable attention due to its improved in vivo relevance cellular communications compared with traditional two-dimensional (2D) culture platform. formation and maintenance a healthy condition is critical factor tissue engineering applications such as repair damaged tissues, development organ replacement parts preclinical drug tests. However, culturing conventional...
In an aging society, bone disorders such as osteopenia, osteoporosis, and degenerative arthritis cause serious public health problems. order to solve these problems, researchers continue develop therapeutic agents, increase the efficacy of developed reduce side effects. Gold nanoparticles (GNPs) are widely used in tissue engineering applications biosensors, drug delivery carriers, bioactive materials. Their special surface property enables easy conjugation with ligands including functional...
Dual stimuli-responsive degradable carbon-based nanoparticles (DS-CNPs) conjugated with Herceptin (HER) and polyethylene glycol (PEG) have been designed for the treatment of HER2-positive breast cancer. Each component has linked through disulfide linkages that are sensitive to glutathione in a cancer microenvironment. β-cyclodextrin (β-CD) on surface DS-CNPs formed an inclusion complex (DL-CNPs) doxorubicin (DOX) at high loading capacity 5.3 ± 0.4%. In response level (GSH) low pH tumor...
Melanoma, a highly malignant and aggressive form of skin cancer, poses significant global health threat, with limited treatment options potential side effects. In this study, we developed temperature-responsive hydrogel for regeneration controllable drug release. The was fabricated using an interpenetrating polymer network (IPN) N-isopropylacrylamide (NIPAAm) poly(vinyl alcohol) (PVA). PVA chosen its adhesive properties, biocompatibility, ability to address hydrophobicity issues associated...
Despite advances in the bio-tissue engineering area, technical basis to directly load hydrophobic drugs on chitosan (CTS) electrospun nanofibers (ENs) has not yet been fully established. In this study, we fabricated CTS ENs by using an electrospinning (ELSP) system, followed surface modification succinyl-beta-cyclodextrin (β-CD) under mild conditions. The β-CD-modified (βCTS) had slightly increased hydrophobicity compared pristine as well decreased residual amine content surface. Through...
Reconstruction of patient-specific scaffolds to repair uniquely shaped bone defects remains a major clinical challenge in tissue engineering. Recently, three-dimensional (3D) printed have received considerable attention as promising technology for the rapid generation custom shapes. However, synthetic polymers commonly used 3D printing, such polycaprolactone (PCL), lack biological capacity mimic native extracellular matrix functions support cell growth and differentiation into desired...
Three-dimensional (3D) printing shows potential for use as an advanced technology forming biomimetic tissue and other complex structures. However, there are limits restrictions on selection of conventional bioinks. Here we report the first 3D-printable platelet lysate (PLMA)-based hydrogel, which consists from whole blood humans that can simulate 3D structure tissues be formed into a crosslinked hydrogel layer-by-layer to build cell-laden constructs through methacrylated...
Microporous hydrogels have been widely used for delivering therapeutic cells. However, several critical issues, such as the lack of control over harsh environment they are subjected to under pathological conditions and rapid egression cells from hydrogels, produced limited outcomes. To address these challenges, cell-tethering hypoxic conditioning colloidal containing mesenchymal stem (MSCs) introduced increase productivity paracrine factors locally in a long-term manner. Cell-tethering that...
Transplanted cells rarely survive because of the inflammatory cytokines after spinal cord injury. To increase survival, we synthesized a hydrophilic and aligned nanofibrous mat. We electrospun thiolate (SH)/aligned (A) poly(lactic-co-glycolic acid) (PLGA) mats. The PLGA-SH mats were conjugated with gold nanoparticles (GNPs) to hydrophilicity. contact angle is decreased from 105.3° ± 5.2 (for randomly directional PLGA mats) 28.1° 2.8 PLGA-GNP mats). Green fluorescent protein (GFP)-expressing...