A5009011336- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- 3D Printing in Biomedical Research
- Nanoparticle-Based Drug Delivery
- Tissue Engineering and Regenerative Medicine
- Hydrogels: synthesis, properties, applications
- Wound Healing and Treatments
- Polymer Surface Interaction Studies
- biodegradable polymer synthesis and properties
- Silk-based biomaterials and applications
- Nanocomposite Films for Food Packaging
- Advanced Polymer Synthesis and Characterization
- Nanoplatforms for cancer theranostics
- Mesenchymal stem cell research
- Periodontal Regeneration and Treatments
- Photodynamic Therapy Research Studies
- Advanced Drug Delivery Systems
- Surgical Sutures and Adhesives
- Cellular Mechanics and Interactions
- Additive Manufacturing and 3D Printing Technologies
- Surface Modification and Superhydrophobicity
- Virus-based gene therapy research
- Polymer Nanocomposite Synthesis and Irradiation
- Biopolymer Synthesis and Applications
- Studies on Chitinases and Chitosanases
Catholic University of Korea
2015-2025
Korea Institute of Radiological and Medical Sciences
2009-2022
Government of the Republic of Korea
2020-2021
Yonsei University
2016-2017
Catholic University of America
1999-2015
Seoul Institute
2015
Joongbu University
2014
Jeonbuk National University
2014
Korea University
2011
Pohang University of Science and Technology
2009
A significant problem that affects tissue-engineered electrospun nanofibrous scaffolds is poor infiltration of cells into the three-dimensional (3D) structure. Physical manipulation can enhance cellular scaffolds. The porosity nanofibers was highly enlarged by ultrasonication in an aqueous solution. and related property changes on a series were observed to be dependent time energy. To evaluate cell scaffold, fibroblasts seeded onto these cultured for different lengths time. penetration...
Despite the fact that advances of burn treatment have led to reduction in morbidity caused by burns, infection is still a serious problem. In this study, we designed blended synthetic and natural polymers nanofiber scaffolds using polyurethane (PU) gelatin, which were prepared an electrospinning method. Silver-sulfadiazine (SSD) was co-mixed polymer solution for being incorporated into nanofibers after electrospinning, followed examination burn-wound healing effect. The containing SSD should...
Regenerative medicine, one of the most exciting and dynamic life science fields, is an emerging biomedical technology for assisting accelerating regeneration repair lost or damaged organs body parts. Modern regenerative medicine increasingly using three-dimensional structured scaffolds because they represent a wide range morphological geometric in vivo possibilities that can be tailored each specific application. This review focuses on polymeric scaffolds, highly promising strategy,...
In this study, we prepared an injectable drug delivery depot system based on a visible light-cured glycol chitosan (GC) hydrogel containing paclitaxel (PTX)-complexed beta-cyclodextrin (β-CD) (GC/CD/PTX) for ovarian cancer (OC) therapy using tumor-bearing mouse model. The had 23.8 Pa of storage modulus at 100 rad/s after light irradiation 10 s. addition, GC was swollen as function time. However, no degradation with the time change. Eventually, matrix affected releases PTX and CD/PTX. GC/PTX...
Poly-l-lysine (PLL) nanoparticle (NP) system was prepared for the controlled release of curcumin (CUR) by pH stimuli, and its theranostic efficacy on cancer compared to that CUR solution in vitro vivo. Deoxycholic acid (DOCA), methoxy polyethylene glycol (MPEG) cyanine 5.5 (cy5.5) were conjugated amine group PLL through condensation reaction (PLL-DOCA-MPEG-cy5.5), followed encapsulation dialysis method (PLL-DOCA-MPEG-cy5.5/CUR NPs). The composition, morphology size distribution...
The collagen-mimetic peptide GFOGER possesses the chondrogenic potential and has been used as a cell adhesion or inducer. Here, we prepared an injectable in situ forming composite hydrogel system comprising methoxy polyethylene glycol-b-polycaprolactone (MPEG-PCL) GFOGER-conjugated PEG-PCL (GFOGER-PEG-PCL) with various concentrations based on our recently patented technology. conjugation of to was confirmed by 1H NMR, particle size distribution rheological properties for sol-gel transition...
The sol-to-gel transition occurring at around body temperature makes the MPEG-PCL diblock copolymer an ideal candidate material for use as injectable in situ–forming gel containing human adipose tissue–derived stem cells (hADSCs). sol can be prepared room temperature, and forms temperature. Solutions of hADSCs osteogenic factors injected into rats formed scaffolds injection sites. gels thus showed interconnective pore structure required to support growth, proliferation, differentiation...
Bone tissue engineering scaffolds offer the merits of minimal invasion as well localized and controlled biomolecule release to targeted sites. In this study, we prepared injectable hydrogel systems based on visible light-cured glycol chitosan (GC) hydrogels containing bone morphogenetic protein-2 (BMP-2) and/or transforming growth factor-beta1 (TGF-β1) for formation in vitro vivo. The were characterized by storage modulus, scanning electron microscopy (SEM) swelling ratio analyses. developed...
Melanoma, a highly malignant and aggressive form of skin cancer, poses significant global health threat, with limited treatment options potential side effects. In this study, we developed temperature-responsive hydrogel for regeneration controllable drug release. The was fabricated using an interpenetrating polymer network (IPN) N-isopropylacrylamide (NIPAAm) poly(vinyl alcohol) (PVA). PVA chosen its adhesive properties, biocompatibility, ability to address hydrophobicity issues associated...
The aim of this study was to investigate the osteogenic potential BMSCs seeded on RGD-conjugated methoxy polyethylene glycol-polycaprolactone (MP–RGD) <italic>in vitro</italic> and vivo</italic>.
The pervaporation separation of water–isopropanol mixtures was carried out using carboxymethylated poly(vinyl alcohol) (CMPVA) composite membranes. Carboxymethylated PVA synthesized by reacting with various concentrations monochloroacetic acid. Substitution efficiency the CMPVA ranged from 12–32%. cross-sectional structure membrane for confirmed scanning electron microscopy (SEM) exhibiting a 20-μm active skin layer. Glass transition temperature in range 74–84°C, and decreased increasing...
Novel star-shaped copolymers consisting of multiarm polyethylene glycol and low molecular weight linear polyethylenimines (MAPEG-LPEIs) with a high transfection efficiency cytotoxicity were designed synthesized as nonviral gene delivery carriers. The cationic polymers prepared by conjugating PEI (2.5 kDa) to six-arm PEG-NHS (10 in two different compositions. Two copolymers, MAPEG-LPEI(3) MAPEG-LPEI(6) weights 17.5 kDa 25 respectively, synthesized. MAPEG-LPEI(3)/pDNA MAPEG-LPEI(6)/pDNA...
Surface-modified titanium (Ti) samples with hydroxyapatite (HAp) and heparin (Hep)–bone morphogenetic protein-2 (BMP-2) complex (Ti/HAp/Hep/BMP-2) were prepared, their efficacies on the enhancements of bone formation osseointegration in vitro vivo examined as compared to Ti/HAp Ti/Hep/BMP-2. The modified surfaces characterized by X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM) contact angle goniometry. In studies revealed that MG-63 human osteosarcoma cell lines...
To develop an appropriate drug carrier for delivery systems, we prepared random poly(lactide-co-glycolide-co-ε-caprolactone) (PLGC) copolymers in comparison to commercial poly(lactic acid-co-glycolic acid) (PLGA) grades. The molecular weights of PLGC varied from 20k 90k g mol-1 the total polyester segments, when poly-l-lactic acid (PLLA), polyglycolic (PGA), and polycaprolactone (PCL) compositions were kept constant. lengths 10 : 80 40 20 PLLA PGA PCL segments crystalline properties PLGA can...