A5100747261- Healthcare and Venom Research
- Pharmacological Effects of Natural Compounds
- Food Quality and Safety Studies
- Gastrointestinal disorders and treatments
- Stress Responses and Cortisol
- Traditional Chinese Medicine Studies
- Gastrointestinal Bleeding Diagnosis and Treatment
- Diverse Approaches in Healthcare and Education Studies
- Gastric Cancer Management and Outcomes
- Cell Adhesion Molecules Research
- Biochemical effects in animals
- Chemokine receptors and signaling
- Eosinophilic Disorders and Syndromes
- Pain Mechanisms and Treatments
- Mesenchymal stem cell research
- Diverse Topics in Contemporary Research
- Cytokine Signaling Pathways and Interactions
- Angiogenesis and VEGF in Cancer
- Gastrointestinal Tumor Research and Treatment
- Neuroendocrine Tumor Research Advances
- Neuroscience and Neuropharmacology Research
- Eosinophilic Esophagitis
- Medicinal Plants and Neuroprotection
- Plant-based Medicinal Research
- Tissue Engineering and Regenerative Medicine
Yonsei University
2021
Soonchunhyang University Hospital
2021
Kyung Hee University
2019
Gachon University
2014-2019
Sejong University
2013-2018
Ministry of Food and Drug Safety
2017
Samsung Medical Center
2016
Sungkyunkwan University
2016
Konkuk University
2015
Konyang University
2010-2014
The future of safe cell-based therapy rests on overcoming teratoma/tumor formation, in particular when using human pluripotent stem cells (hPSCs), such as embryonic (hESCs) and induced (hiPSCs). Because the presence a few remaining undifferentiated hPSCs can cause undesirable teratomas after transplantation, complete removal these with no/minimal damage to differentiated is prerequisite for clinical application hPSC-based therapy. Having identified unique hESC signature pro- antiapoptotic...
Abstract In this study, we have characterized the signaling pathways mediated by CXCR4 in breast cancer cells and its role cell invasion migration. Stromal cell-derived factor 1α (SDF-1α; CXCL12) stimulation of resulted phosphoinositide 3-kinase (PI-3K) activation, AKT phosphorylation, activation FKHRL1 transcription factor. addition, SDF-1α induced focal adhesion kinase (FAK) as well migration cells. Expression SDF-1α, ligand CXCR4, was about 2-fold higher microdissected human epithelial...
Vascular endothelial growth factor (VEGF) plays a significant role in blood-brain barrier breakdown and angiogenesis after brain injury. VEGF-induced cell migration is key step the angiogenic response mediated by an accelerated rate of focal adhesion complex assembly disassembly. In this study, we identified signaling mechanisms which VEGF regulates human microvascular (HBMEC) integrity adhesions, complexes comprised scaffolding proteins organized to extracellular matrix. We found that...
Previous studies conducted cell expansion ex vivo using low initial plating densities for optimal and subsequent differentiation of mesenchymal stem cells (MSCs). However, MSC populations are heterogeneous culture conditions can affect the characteristics MSCs. In this study, differences in gene expression profiles adipose tissue (AT)-derived MSCs were examined after harvesting cultured at different densities. AT-MSCs from three donors plated a density 200 or 5,000 cells/cm2. After 7 days...
The results of clinical trials using mesenchymal stem cells (MSCs) are controversial due to the heterogeneity human MSCs and differences in culture conditions. In this regard, it is important identify gene expression patterns according conditions, determine how expanded when they should be clinically used. current study, stemness was investigated adipose tissue-derived (AT-MSCs) harvested following at different densities. AT-MSCs were plated a density 200 or 5,000 cells/cm2. After 7 days...
Abstract The blood-brain barrier (BBB) is a network formed mainly by brain microvascular endothelial cells (BMECs). integrity of the BBB critical for function. Breakdown commonly seen in AIDS patients with HIV-1-associated dementia despite lack productive HIV infection endothelium. processes which causes these pathological conditions are not well understood. In this study we characterized molecular mechanisms Tat mediates its pathogenic effects vitro on primary human BMECs (HBMECs)....
Cancer stemness, observed in several types of glioma stem cells (GSCs), has been demonstrated to be an important barrier for efficient cancer therapy. We have previously reported that cancerous neural (F3.Ras.CNSCs), derived from immortalized human by a single oncogenic stimulation, form glial tumors vivo. searched commonly expressed stress modulator both F3.Ras.CNSCs and GSCs identified silent mating type information regulation 2, homolog (SIRT1) as key factor maintaining stemness....
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrosing interstitial pneumonia of unknown etiology. In several randomized clinical trials, and in the practice, pirfenidone used to effectively safely treat IPF. However, sometimes it difficult use dose trials. This study evaluated effects low-dose on IPF disease progression patient survival real-world.
Abstract Using microarray gene analysis, we found that carboxyl-terminal Src kinase homologous (CHK) regulated the expression of chemokine receptor, CXCR4. Northern blot and fluorescence-activated cell-sorting analyses showed CHK down-regulated CXCR4 mRNA protein levels, respectively. Mutated CHK, which contains a mutation within ATP binding site failed to inhibit expression, thus suggesting activity is involved in regulation Results from gel shift analysis indicated regulates...
The molecular mechanism underlying the initiation of somatic cell reprogramming into induced pluripotent stem cells (iPSCs) has not been well described. Thus, we generated single-cell-derived clones by using a combination drug-inducible vectors encoding transcription factors (Oct4, Sox2, Klf4 and Myc) single-cell expansion strategy. This system achieved high efficiency after metabolic epigenetic remodeling. Functional analyses cloned revealed that extracellular signal-regulated kinase (ERK)...
Platycodin D (PD), one of several triterpene saponins, was isolated from roots Platycodon grandiflorum. We previously reported that intracerebroventricular (i.c.v.) administration PD showed an antinociceptive effect as measured by the tail-flick assay. However, its exact role in regulation antinociception various types pain models has not yet been characterized. Thus, we attempted to find profiles models. administered intraperitoneally (i.p.), i.c.v. or intrathecally (i.t.) effects...
Ephedra sinica Stapf (EH) exert toxic effects, such as excitability, cardiac arrhythmia, and others. On the contrary, in traditional herbal medicine, EH gypsum (GF) are used most often to treat symptoms caused by external stressors. The hypothalamus plays a crucial role thermal homeostasis. Inflammatory response stressors may affect energy This study investigates effect of GF against heat-induced mouse model. Mice were divided into four groups: saline, saline plus heat, heat treated groups....
Platycodin D administered intracerebroventricularly (i. c. v.) showed an antinociceptive effect in a dose-dependent manner as measured by the tail-flick assay. The antinociception induced platycodin was maintained at least 1 h. MK-801 [(±)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate], competitive N-methyl-D-aspartic acid (NMDA) receptor antagonist, or CNQX (6-cyano-7-nitroquinoxaline-2,3-dione), non-NMDA muscimol (a GABAA agonist), baclofen GABAB antagonist),...
Lappaconitine, a diterpene alkaloid isolated from Aconitum sinomontanum Nakai, exhibits wide range of biological activities, making it promising candidate for the development novel derivatives with therapeutic potential. In our research, we executed two-step transformation via oxidative cleavage lappaconitine's vicinal diol using hypervalent iodine reagent PhI(OAc)2, followed by strong alkaline hydrolysis. This approach yielded four new unanticipated compounds, whose structures were...
Ex vivo expansion of hematopoietic stem/progenitor cell (HSPC) has been investigated to improve the clinical outcome HSPC transplantation. However, ex HSPCs still faces a major obstacle in that HPSCs tend differentiate when proliferating. Here, we cocultured with mesenchymal stem cells (MSCs) and divided into two fractions according whether they came adherent MSCs or not. Additionally, used hydrostatic pressure (HP) mimic physical conditions . Even nonadherent expanded yield significantly...
Chronic active EBV infection (CAEBV) of T-cell or NK-cell type is an EBV+ polyclonal, oligoclonal often monoclonal lymphoproliferative disorder (LPD) recognized as representing the spectrum EBV-associated and LPD with different clinical presentations; one systemic two cutaneous disorders including hydroa vacciniforme-like mosquito bite hypersensitivity. The form disease characterized by fever, persistent hepatitis, hepatosplenomegaly lymphadenopathy, which shows varying degrees severity...
This study aims to compare the prevalence and seriousness of adverse events (AEs) among sedatives used in critically ill patients or undergoing invasive procedures identify factors associated with serious AEs. Retrospective cross-sectional analysis sedative-related AEs voluntarily reported Korea Adverse Event Reporting System from 2008 2017 was performed. All were grouped using preferred terms Organ Classes per World Health Organization—Adverse Reaction Terminology. Logistic regression...
cystic lymphangioma is an uncommon disease, and rarely develops in the intraabdomen. The aim of this article was to discuss about clinical characteristics intraabdominal developed Korea.age, sex, symptoms, locations size lesions, diagnostic methods, treatments, complications recurrence were analyzed 13 pathologically confirmed cases 18 literature consideration reported Korea.intraabdominal commonly adults compared other lymphangioma, frequently located mesentery. Abdominal pain most common...
Objectives : The goal of this study was to investigate the antidepressant effects Mixture Lycii Radicis Cortex and Moutan on change HPA-Axis Catecholamic system. Methods We were performed Forced Swimming Test. expressions Corticotropin-Releasing Factor (CRF) c-Fos at paraventricular nucleus (PVN), tyrosine hydroxylase (TH) ventral tegmental area (VTA) locus coeruleus (LC) evaluated by immunohistochemical method. Results duration immobility in Test significantly decreased A100, A400(p