A5017921394- Calcium signaling and nucleotide metabolism
- Sirtuins and Resveratrol in Medicine
- Adenosine and Purinergic Signaling
- PARP inhibition in cancer therapy
- Cytokine Signaling Pathways and Interactions
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Ion Channels and Receptors
- Advanced biosensing and bioanalysis techniques
- Neonatal Health and Biochemistry
- Vibrio bacteria research studies
- Molecular Sensors and Ion Detection
- Microtubule and mitosis dynamics
- Ion channel regulation and function
- Peroxisome Proliferator-Activated Receptors
- NF-κB Signaling Pathways
- Lipid Membrane Structure and Behavior
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- PI3K/AKT/mTOR signaling in cancer
- Tea Polyphenols and Effects
- Genomics, phytochemicals, and oxidative stress
- T-cell and B-cell Immunology
- Mast cells and histamine
- Nitric Oxide and Endothelin Effects
Jeonbuk National University
2016-2025
Chonbuk National University Hospital
2016
Czech Academy of Sciences, Institute of Microbiology
2011
Indiana University – Purdue University Indianapolis
2005-2008
Indiana University School of Medicine
2005-2008
Walther Cancer Foundation
2005-2007
Gachon University Gil Medical Center
2007
Samsung Medical Center
2004-2007
Indiana University
2007
Sungkyunkwan University
2004
OBJECTIVE—SIRT1, a class III histone/protein deacetylase, is known to interfere with the nuclear factor-κB (NF-κB) signaling pathway and thereby has an anti-inflammatory function. Because of central role NF-κB in cytokine-mediated pancreatic β-cell damage, we postulated that SIRT1 might work damage models. RESEARCH DESIGN AND METHODS—RINm5F (RIN) cells or isolated rat islets were treated interleukin-1β interferon-γ. was activated by resveratrol, pharmacological activator, ectopic...
Nephrotoxicity is one of the important dose-limiting factors during cisplatin treatment. There a growing body evidence that activation p53 has critical role in cisplatin-induced renal apoptotic injury. The nicotinamide adenine dinucleotide-dependent protein deacetylase SIRT1 decreases apoptosis through deacetylating p53, and resveratrol known as an activator SIRT1. To study injury interaction with mouse proximal tubular cells (MPT) were treated examined expression level SIRT1, acetylation...
An easily accessible colorimetric and fluorescence probe 4-((3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino)benzenesulfonamide (4CBS) was successfully developed for the selective sensitive detection of Sn2+ in an aqueous solution. The sensing mechanism involves reduction −C═O into −C–OH groups 4CBS upon addition Sn2+, which initiates turn-on mode. A better linear relationship achieved between intensity concentration range 0–62.5 μM, with a limit (LOD) 0.115 μM. binding confirmed by...
Objective. MMP is a key enzyme in the degradation of extracellular matrices, and its expression plays important roles inflammatory diseases. Cordycepin (3′-deoxyadenosine), bioactive compound Cordyceps militaris, has been shown to exhibit many pharmacological activities, such as anti-cancer, anti-inflammatory anti-infection activities. In this study, we aimed at inhibitory effect cordycepin on IL-1β-induced MMP-1 MMP-3 well molecular basis using RA synovial fibroblasts (RASFs).
1,4-Naphthoquinones are an important class of compounds present in a number natural products. In this study, new series 1,4-naphthoquinone derivatives were synthesized. All the synthesized tested for vitro antimicrobial activity. investigation, two Gram-positive and five Gram-negative bacterial strains one pathogenic yeast strain used to determine antibacterial Naphthoquinones its potencies, among seven them displayed better activity against Staphylococcus aureus (S. aureus; 30-70 μg/mL)....
Cytokines produced by immune cells infiltrating pancreatic islets have been implicated as one of the important mediators β-cell destruction in insulin-dependent diabetes mellitus. In this study, protective effects epigallocatechin gallate (EGCG) on cytokine-induced were investigated. EGCG effectively protected IL-1β and IFN-g-mediated cytotoxicity insulinoma cell line (RINm5F). induced a significant reduction IL-1b IFN-γ-induced nitric oxide (NO) production reduced levels inducible form NO...
Crosstalk between intracellular signaling pathways has been extensively studied to understand the pluripotency of human pluripotent stem cells (hPSCs), including embryonic and induced (hiPSCs); however, contribution NAD(+) -dependent remains largely unknown. Here, we show that depletion by FK866 (a potent inhibitor biosynthesis) was fatal in hPSCs, particularly when deriving from somatic maintaining pluripotency. NAD its precursors (nicotinamide [NAM] nicotinic acid) fully replenished hPSCs....
Objective SIRT1 modulates the acetylation of p65 subunit nuclear factor-κB (NF-κB) and plays a pivotal role in inflammatory response. This study sought to assess rheumatoid arthritis (RA) using myeloid cell-specific knockout (mSIRT1 KO) mouse. Methods mSIRT1 KO mice were generated loxP/Cre recombinase system. K/BxN serum transfer was induced age-matched littermate loxP control mice. Arthritis severity assessed by clinical pathological scoring. The levels cytokines joints measured ELISA....
Reactive oxygen species (ROS) play a major role in both chronological aging and photoaging. ROS induce skin through their damaging effect on cellular constituents. However, the origins of have not been fully elucidated. We investigated that generation replicative senescent fibroblasts is generated by modulation phosphatidylinositol 3,4,5-triphosphate (PIP3) metabolism. Reduction PTEN protein, which dephosphorylates PIP3, was responsible for maintaining high level PIP3 cells consequently...
In this work, sulfonated diblock copolymers (SDBCs) were prepared by polycondensation of poly(ether-ether-ketone) (SPEEK) and hydrophobic oligomer, which combined with sintered anatase titanium oxide (S-An-TiO2) to create a hybrid membrane for apply in proton exchange fuel cells (PEMFCs) operating low relative humidity (RH). Then, series composite membranes (SDBC/S-An-TiO2) varying the wt% S-An-TiO2 blended SDBC. The results showed that appropriate quantity (ie, 15 wt%) can significantly...
Although tryptase released from mast cells might play a key role in the pathogenesis of ulcerative colitis (UC), protease-activated receptor 2 (PAR2), receptor, remains unclear this disease. The expressions PAR2 and tumor necrosis factor (TNF) alpha nine UC tissues normal were examined by immunohistochemistry. TNF-alpha levels secreted human leukemic cell line (HMC-1) after treatment agonists also measured enzyme-linked immunosorbent assay. proteins more significantly detectable than...
Abstract Objective To determine whether CD40 ligation of rheumatoid arthritis synovial fibroblasts (RASFs) is able to induce RANKL expression and osteoclastogenesis in RASFs, identify its mechanism action patients with RA. Methods RASFs was ligated ligand (CD40L)–transfected L cells or activated T cells. The formation osteoclasts cocultures CD40‐ligated lymphocyte–depleted peripheral blood mononuclear evaluated by tartrate‐resistant acid phosphatase staining, detection calcitonin receptor,...