A5100711475- Ecology and Conservation Studies
- Iron Metabolism and Disorders
- Plant Virus Research Studies
- Glioma Diagnosis and Treatment
- Agriculture, Soil, Plant Science
- Plant Disease Resistance and Genetics
- Mycorrhizal Fungi and Plant Interactions
- Alzheimer's disease research and treatments
- Marine and coastal plant biology
- Erythropoietin and Anemia Treatment
- Trace Elements in Health
- Plant Pathogens and Fungal Diseases
- Plant and animal studies
- Hemoglobinopathies and Related Disorders
- Cancer, Hypoxia, and Metabolism
- Plant and Fungal Interactions Research
- Genomics, phytochemicals, and oxidative stress
- Neurofibromatosis and Schwannoma Cases
- Ferroptosis and cancer prognosis
- Lichen and fungal ecology
- Medicinal Plant Extracts Effects
- Folate and B Vitamins Research
- Neuroblastoma Research and Treatments
- Metabolism and Genetic Disorders
- Systemic Sclerosis and Related Diseases
Johns Hopkins University
2023
Johns Hopkins Medicine
2023
Kyungpook National University
1991-2023
Pennsylvania State University
2010-2021
Sun Moon University
2021
University of Miami
2013-2021
John Wiley & Sons (United States)
2019-2020
Korea Forest Service
2013-2020
Hudson Institute
2019-2020
Moss Landing Marine Laboratories
2020
PURPOSE: To assess technical feasibility, efficacy, and complications of percutaneous computed tomography (CT)-guided transthoracic radiofrequency (RF) ablation for treating inoperable non–small cell lung cancer (NSCLC) metastases. MATERIALS AND METHODS: Twenty-six patients with 27 NSCLCs four five metastases underwent RF cooled-tip electrodes CT guidance. Patients were not candidates surgery because either advanced-stage disease (n = 20) and/or comorbid processes 4) or refusal to undergo...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of optically active 2-(diarylphosphino)-1,1'-binaphthyls, efficient chiral monodentate phosphine ligandsYasuhiro Uozumi, Asako Tanahashi, Sang Yong Lee, and Tamio HayashiCite this: J. Org. Chem. 1993, 58, 7, 1945–1948Publication Date (Print):March 1, 1993Publication History Published online1 May 2002Published inissue 1 March 1993https://pubs.acs.org/doi/10.1021/jo00059a059https://doi.org/10.1021/jo00059a059research-articleACS...
Nephrotoxicity is one of the important dose-limiting factors during cisplatin treatment. There a growing body evidence that activation p53 has critical role in cisplatin-induced renal apoptotic injury. The nicotinamide adenine dinucleotide-dependent protein deacetylase SIRT1 decreases apoptosis through deacetylating p53, and resveratrol known as an activator SIRT1. To study injury interaction with mouse proximal tubular cells (MPT) were treated examined expression level SIRT1, acetylation...
Abstract Suppression of an excessive systemic inflammatory response is a promising and potent strategy for treating endotoxic sepsis. Indoleamine 2,3-dioxygenase (IDO), which the rate-limiting enzyme tryptophan catabolism, may play critical role in various disorders. In this study, we report IDO dysregulated immune associated with endotoxin shock. We found that knockout (IDO−/−) mice 1-methyl-d-tryptophan-treated, endotoxin-shocked had decreased levels cytokines, TNF-α, IL-6, IL-12, enhanced...
Injury to the renal microvasculature may be a major factor in progression of disease; therefore, protection endothelial cells (EC) vasculature have therapeutic role fibrosis. Recently, soluble, stable, and potent angiopoietin-1 (Ang1) variant, cartilage oligomeric matrix protein (COMP)-Ang1, was developed. The contribution COMP-Ang1 interstitial fibrosis, however, remains clarified. This study investigated effects on peritubular capillary EC cortex fibrogenic process that is triggered by...
Abstract Objective Nuclear factor‐κB (NF‐κB) has been implicated as a therapeutic target for the treatment of rheumatoid arthritis (RA). The purpose this study was to determine whether A20, universal inhibitor NF‐κB, might have antiarthritic effects. Methods An adenovirus containing A20 complementary DNA (AdA20) used deliver human fibroblast‐like synoviocytes (FLS) in vitro well mice with collagen‐induced (CIA) vivo via intraarticular injection into ankle joints bilaterally. Results In...
Cancer therapy often produces anemia, which is treated with erthropoietin (EPO) to stimulate erythrocyte production. However, concerns have recently arisen that EPO treatment may promote later tumor metastasis and mortality. The mechanisms underlying such effects are unknown, but it clear has pleiotropic in cell types other than hematopoietic cells. In this study, we investigated how affects lymphangiogenesis lymph node mouse models of breast cancer melanoma. these models, increased a manner...
Clinical studies suggest that estrogen may improve cognition in Alzheimer's patients. Basic experiments demonstrate 17beta-estradiol protects against neurodegeneration both cell and animal models. In the present study, a human SH-SY5Y model was used to investigate molecular mechanisms underlying receptor-mediated neuroprotection of physiological concentrations 17beta-estradiol. (<10 nM) concomitantly increased neuronal nitric oxide synthase (NOS1) expression viability....
Ischemia followed by reperfusion induces microvascular endothelial cell injury, leading to the loss of functions such as regulation vascular tone, tissue perfusion, permeability, and inflammation in kidney. Improvement this dysfunction could be a good approach treating ischemia-reperfusion-induced renal injury. Cartilage oligomeric matrix protein-angiopoietin-1 (COMP-Ang1) is variant native angiogenic factor angiopoietin-1 engineered have higher activity. We evaluated protective effect...
A specific polymorphism in the hemochromatosis (HFE) gene, H63D, is over-represented neurodegenerative disorders such as amyotrophic lateral sclerosis and Alzheimer disease. Mutations of HFE are best known being associated with cellular iron overload, but mechanism by which H63D might increase risk neuron degeneration unclear. Here, using an inducible expression cell model developed from a human neuronal line SH-SY5Y, we reported that presence protein activated unfolded response (UPR). This...
Cabbage is a relatively robust vegetable at low temperatures. However, high temperatures, cabbage has disadvantages, such as reduced disease tolerance and lower yields. Thus, selection of heat-tolerant an important goal in breeding. Easier or faster superior varieties cabbage, which are tolerant to heat have improved taste quality, can be achieved with molecular biological methods. We compared heat-responsive gene expression between line (HTCL), “HO”, heat-sensitive (HSCL), “JK”, by Genechip...
Preconditioning stress induced by a transient ischemia may increase brain tolerance to oxidative stress, and the underlying neuroprotective mechanisms are not well understood. In series of experiments, we found that endogenous nitric oxide (NO), S-nitrosoglutathione (GSNO), antioxidants blocked serum deprivation-induced apoptosis in human neuroblastoma cells. Similar nuclear redox factor-1 (Ref-1), mRNA neuronal synthase (hNOS1) was maximally up-regulated within 2 h after down-regulated...
Oxidative stress and inflammation are implicated in the pathogenesis of cisplatin-induced nephrotoxicity. l-2-oxothiazolidine-4-carboxylic acid (OTC) is a cysteine prodrug, increases cellular glutathione (GSH). OTC converted to by intracellular enzyme, oxoprolinase. To date, protective role on renal injury has not been investigated. The purpose present study was examine effect mechanism its protection.Mice were treated with cisplatin or without administration OTC. generation reactive oxygen...
Up-regulation of fractalkine is involved in vascular and tissue damage inflammatory conditions. Resveratrol has been shown to have anti-inflammatory, antioxidant, antitumor activities. Its regulatory effects on expression endothelial cells receptor CX3CR1 monocytes not studied. We evaluated the resveratrol human umbilical vein THP-1 response treatment with tumor necrosis factor (TNF)-α. TNF-α significantly induced mRNA protein cells. strongly suppressed TNF-α-induced through suppression...
Abstract Background Polymorphisms in the MHC class 1-like gene known as HFE have been proposed genetic modifiers of neurodegenerative diseases that include neuroinflammation part disease process. Variants are relatively common general population and most commonly associated with iron overload, but can promote subclinical cellular loading even absence clinically identified disease. The effects variants well resulting dyshomeostasis potentially impact a number disease-associated pathways. We...
Abstract Neurofibromatosis type 1 (NF1) is an autosomal dominant condition in which patients are heterozygous for a disruptive pathogenic variant the NF1 gene. The most characteristic feature of neurofibroma, benign, multi-cellular tumor initiates when cell Schwann lineage gains somatic other allele. Neurofibromas developing at nerve termini skin termed “cutaneous” neurofibromas (cNFs), while those within larger nerves “plexiform.” Most develop cNFs beginning late childhood or early...
Abstract The temporal dynamics of two seagrass species, Zostera marina and Z. japonica , were monitored monthly in Dadae Bay, Geoje Island, on the southern coast Korea. Plant morphological characteristics, shoot density, biomass, leaf production, reproductive effort, environmental characteristics from July 2001 to 2002. occurred intertidal zone subtidal 0.5 2.5 m below mean low water level. Shoots rhizomes significantly larger than whereas density was greater . Despite differences morphology...