A5065130530- Neurotransmitter Receptor Influence on Behavior
- Molecular Sensors and Ion Detection
- Nicotinic Acetylcholine Receptors Study
- Metal-Organic Frameworks: Synthesis and Applications
- Forensic Toxicology and Drug Analysis
- Aluminum toxicity and tolerance in plants and animals
- Neuroscience and Neuropharmacology Research
- Magnesium in Health and Disease
- Advanced biosensing and bioanalysis techniques
- Heavy Metal Exposure and Toxicity
- Synthesis and Biological Evaluation
- Liver Disease Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Luminescence and Fluorescent Materials
- Liver physiology and pathology
- Protease and Inhibitor Mechanisms
- Organic Chemistry Cycloaddition Reactions
- Trace Elements in Health
- Chemical synthesis and alkaloids
- Tryptophan and brain disorders
- Human Health and Disease
- Cholinesterase and Neurodegenerative Diseases
- Thallium and Germanium Studies
- Fluoride Effects and Removal
- Alkaloids: synthesis and pharmacology
Medical University of Lublin
2016-2025
Instytut Medycyny Wsi im. Witolda Chodźki
2004
Academic Center of Medicine
2003
Imperatorin, a naturally occurring furanocoumarin, inactivates gamma-aminobutyric acid transaminase and inhibits acetylcholinesterase activity.The purpose of our experiment was to examine the influence imperatorin on cognitive impairment oxidative stress in brain induced by scopolamine male Swiss mice.In present studies, we used scopolamine-invoke memory deficit measured passive avoidance (PA) paradigm as an animal model Alzheimer disease (AD).Our finding revealed that administered acutely...
A new naphthoquinone-based chemosensor 2-((3-hydroxyphenyl)amino)-3-(phenylthio)naphthalene-1,4-dione (2HPN) was successfully synthesized for the selective detection of Fe2+. The sensing property 2HPN evaluated in aqueous acetonitrile (CH3CN) medium by a fluorescence emission method. metal-binding studies ligand showed "turn-on" responses Fe2+ (Ka = 1.0 × 106 M–1). limit to calculated be 0.272 μM, which is lower than World Health Organization recommendation (0.3 mg/L) drinking water. most...
An easily accessible colorimetric and fluorescence probe 4-((3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino)benzenesulfonamide (4CBS) was successfully developed for the selective sensitive detection of Sn2+ in an aqueous solution. The sensing mechanism involves reduction −C═O into −C–OH groups 4CBS upon addition Sn2+, which initiates turn-on mode. A better linear relationship achieved between intensity concentration range 0–62.5 μM, with a limit (LOD) 0.115 μM. binding confirmed by...
Xanthotoxin, popularly occurring furanocoumarin, which can be found in plants from the Apiaceae family, was isolated fruits of Pastinaca sativa L. by mean high-performance countercurrent chromatography, and its effects on scopolamine-induced cognitive deficits male Swiss mice using passive avoidance (PA) test were evaluated. To measure acquisition memory processes, xanthotoxin (1, 2.5, 5 mg/kg) administered 30 min before PA scopolamine 10 after xanthotoxin. consolidation (1 2.5 injected...
The removal of uremic toxins from patients with acute kidney injury is a key issue in improving the quality life for people requiring peritoneal dialysis. currently utilized method human organism hemodialysis, performed on semipermeable membranes where toxins, along small molecules, are separated proteins and blood cells. In this study, we describe mixed-linker modulated synthesis zirconium-based metal–organic frameworks efficient toxins. We determined that adsorption achieved by optimizing...
The cyclodextrin-based metal–organic frameworks (CD MOFs) are a suitable molecular platform for drug delivery systems of various active pharmaceutical ingredients (APIs). low toxicity and cost-efficient synthesis make CD MOFs an attractive host the encapsulation APIs. In this study, we created model system based on γCD-K with widely used drugs carmofur (HCFU), 5-fluorouracil (5-FU), salicylic acid (HBA) to study host–guest methods using different crystallization protocols. complexes API:CD...
The mechanistic aspects of the hetero Diels–Alder reactions between strongly electrophilic (E)-2-aryl-1-cyano-1-nitroethenes and ethyl vinyl ether have been analyzed on basis kinetic experimental results as well quantum chemical simulations reaction paths. These may theoretically proceed via one step or stepwise, zwitterionic mechanism. It was found that conversion addends into adducts carried out polar, but not This is confirmed by substituent solvent effects. Subsequently, a detailed...
Cosmetic products contain preservatives to prevent microbial growth. The various types of present in skincare applied on the skin induce many side effects. We tested several such as phenoxyethanol, methyl paraben, propyl imidazolidinyl urea (IU), composition gluconolactone and sodium benzoate (GSB), diazolidinyl (DU), two grapefruit essential oils, one which was industrially produced a second freshly distilled from fresh peels. This study aimed find relationship between preservative...
Nicotine, the main component of tobacco smoke, exerts influence on mood, and contributes to physical psychological dependence. Taking into account frequent concomitance nicotine abuse stress, we aimed research behavioral biochemical effects associated with administration in combination chronic unpredictable mild stress (CUMS). Mice were submitted procedure CUMS for 4 weeks, 2 h per day. Our results revealed that CUMS-exposed animals exhibited alteration like anxiety disorders elevated plus...
In alcoholic liver cirrhosis, normal cells are replaced by scar tissue (fibrosis). Liver fibrosis is a dynamic process in which activated hepatic stellate involved the synthesis of matrix proteins and regulation degeneration. The aim presented study was to assess usefulness MMP-2, MMP-8 MMP-9 as diagnostic markers disease. Sixty patients with cirrhosis were randomly enrolled during hospitalization departments hospitals from Lublin Region eastern Poland. stage estimated according...
In this study, we present a modulated synthesis nanocrystalline defective UiO-66 metal-organic framework as potential chloroquine diphosphate (CQ) delivery system. Increasing the concentration of hydrochloric acid during resulted in considerable increase pore volume, which enhanced CQ loading CQ@UiO-66 composites. Drug release tests for composites have confirmed prolonged comparison with pure CQ. vivo on Danio reiro model organism revealed that released from 25% showed lower toxicity and...
In this study, we present a complementary approach for obtaining an effective drug, based on acriflavine (ACF) and zirconium-based metal–organic frameworks (MOFs), against SARS-CoV-2. The experimental results showed that inhibits the interaction between viral receptor-binding domain (RBD) of spike protein angiotensin converting enzyme-2 (ACE2) host receptor driving cell entry. prepared ACF@MOF composites exhibited low (MOF-808 UiO-66) high (UiO-67 NU-1000) ACF loadings. drug release profiles...
Abstract Aquatic plants are a rich source of health-beneficial substances. One such organisms is the submerged macrophyte Ceratophyllum demersum , which has not been sufficiently studied in this aspect so far. In work, we have environmental conditions prevailing subsidence mining reservoir Eastern Poland and shown that C. can be harvested for further analysis even from artificial anthropogenic reservoirs. The phytochemical ethanolic extract using LC–MS revealed high content phenolic...
Many people around the world suffer from neurodegenerative diseases associated with cognitive impairment. As life expectancy increases, this number is steadily rising. Therefore, it extremely important to search for new treatment strategies and discover substances potential neuroprotective and/or cognition-enhancing effects. This study focuses on investigating of astragaloside IV (AIV), a triterpenoid saponin proven acetylcholinesterase (AChE)-inhibiting activity naturally occurring in root...
Drug resistance has become a major concern in the field of infection management, therefore searching for new antibacterial agents is getting more challenging. Our study presents an optimized and eco-friendly synthesis scheme panel nitroalkenes bearing various functional groups aromatic moiety bromine or cyano substituents 1 position nitrovinyl moiety. The presence nitrolefine group outside ring minimalizes genotoxic properties while conjugation aryl with increases stability compounds. Then...
Background. The aim of the study was to assess activity interleukin-1α, interleukin-6, and hepatocyte growth factor protein (HGF) in serum patients with alcoholic liver cirrhosis. Materials Methods. Sixty cirrhosis treated various hospitals were randomly enrolled. stage assessed according Child-Turcotte-Pugh scoring system. control group consisted ten healthy persons without disease, who did not drink alcohol. Additionally, alcoholics included study. HGF blood plasma controls measured using...
The endocannabinoid system, through cannabinoid (CB) receptors, is involved in memory-related responses, as well processes that may affect cognition, like oxidative stress processes. purpose of the experiments was to investigate impact CB1 and CB2 receptor ligands on long-term memory stages male Swiss mice, using passive avoidance (PA) test, influence these compounds level biomarkers mice brain. A single injection a selective antagonist, AM 251, improved acquisition consolidation PA test...