In alcoholic liver cirrhosis, normal cells are replaced by scar tissue (fibrosis). Liver fibrosis is a dynamic process in which activated hepatic stellate involved the synthesis of matrix proteins and regulation degeneration. The aim presented study was to assess usefulness MMP-2, MMP-8 MMP-9 as diagnostic markers disease. Sixty patients with cirrhosis were randomly enrolled during hospitalization departments hospitals from Lublin Region eastern Poland. stage estimated according...

1. Dey P, Saha MR, Sen A. Hepatotoxicity and the present herbal hepatoprotective scenario. Int J Green Pharm. 2013; 7: 265–273. Google Scholar

According to some authors, serum selenium levels are strongly associated with the severity of liver diseases, including cirrhosis. The aim this study was determine relationship between concentration and pro-inflammatory profibrotic cytokines-interleukin-6 (IL-6) growth differentiation factor 15 (GDF-15) in patients alcoholic parameters studied were determined 99 cirrhosis divided based on disease according Child-Turcotte-Pugh criteria. In cirrhosis, statistically lower, whereas IL-6 GDF-15...

Background. The aim of the study was to assess activity interleukin-1α, interleukin-6, and hepatocyte growth factor protein (HGF) in serum patients with alcoholic liver cirrhosis. Materials Methods. Sixty cirrhosis treated various hospitals were randomly enrolled. stage assessed according Child-Turcotte-Pugh scoring system. control group consisted ten healthy persons without disease, who did not drink alcohol. Additionally, alcoholics included study. HGF blood plasma controls measured using...

According to the WHO report, alcohol is third most significant health risk factor for global population. There are contrary reports about heavy metals concentrations in patients with alcoholic liver cirrhosis. The aim of this study was investigate serum selected cirrhosis living eastern part Poland according stage. participants came from various hospitals Lublin region were enrolled. group included 46 male and 16 female patients. control consisted 18 healthy individuals without disease. High...

The aim of this study was to determine if altered levels selected trace elements manifest themselves during chronic depression. To identify strongly associated with depression, relationships between the elemental contents hair and nails interelement correlations were checked. Inductively coupled plasma mass spectrometry ion chromatography used evaluate Zn, Cu, Co, Pb, Mn, Fe in nail samples from a total 415 subjects (295 patients 120 healthy volunteers). included logistic regression models...

Amyloid-β 1-40 (Aβ 1-40) and amyloid-β 1-42 1-42) are the proteins known to be involved in pathogenesis of Alzheimer's disease (AD)-the most common cause dementia elderly. Hypoxia is suspected one conditions associated with Aβ plasma level increase. A reason hypoxia obstructive sleep apnea (OSA), characterized by recurrent episodes apnea.The aim study was evaluate concentrations patients OSA.Patients OSA (n = 112) underwent polygraphic examinations Patients confirmed 81) showed...

Cardiovascular diseases (CVDs) constitute the first cause of death among population developing and developed countries. Atherosclerosis, which is a disorder with multifactorial etiopathogenesis, underlies most CVDs. The available literature includes ample research studies on influence classic cardiovascular (CV) risk factors. However, environmental exposure to heavy metals, other substances, still an unappreciated factor This study aimed assess concentration some metals (copper (Cu), zinc...

1. Pilśniak J, Ślusarz R. Epidemiologia urazów czaszkowo-mózgowych w materiale własnym Pogotowia Ratunkowego Rypinie: Badania retrospektywne. Pielęgniarstwo Neurologiczne i Neurochirurgiczne 2013; 2(1): 4–8 (in Polish). Google Scholar

The aim of the present study was to evaluate concentrations fetuin-A, osteoprotegerin (OPG) and α-Klotho protein in patients with alcoholic cirrhosis at different stages disease, demonstrate that osteoprotegin may be used as markers severity cirrhosis. A total 54 liver treated various hospitals Lublin region Poland were randomly enrolled. control group consisted 18 healthy individuals without who did not drink alcohol. Serum levels OPG measured by ELISA kits. Levels fetuin-A significantly...

Background:Hyperlipidemia is an identified factor of premature vessel atherosclerosis. Lipemia retinalis unusual retinal manifestation hyperlipidemia and thought to be directly correlated with the serum triglyceride level.Case Report:This paper discusses case a 55-year-old patient lipemia retinalis, which deteriorated his visual acuity. The had extremely high cholesterol level (1053 mg/dl) very triglycerides (1513 mg/dl). normalization lipids, reversion vessels alterations acuity improvement...

According to some authors, the serum selenium level is strongly associated with severity of liver diseases including cirrhosis. The aim study was determine relationship between concentration and pro-inflammatory profibrotic cytokines – interleukin-6 (IL-6) growth differentiation factor 15 (GDF-15) in patients alcoholic parameters studied were determined 99 cirrhosis divided based on disease according Child-Turcotte-Pugh criteria. In cirrhosis, statistically lower whereas IL-6...

1. Blachier M, Leleu H, Peck-Radosavljevic Valla D-C, Roudot-Thoraval F. The burden of liver disease in Europe: A review available epidemiological data. J Hepatol. 2013; 25(3): 593–608. CrossRef Google Scholar

1. Mokdad AA, Lopez AD, Shahraz S, Lozano R, AH, Stanaway J, Murray CJ, Naghavi M. Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis. BMC Med. 2014; 12: 14, doi: 10.1186/s12916–014–0145-y. CrossRef Google Scholar

1. Blachier M, Leleu H, Peck-Radosavljevic Valla D-C, Roudot Thoraval F. The burden of liver disease in Europe: A review available epidemiological data. J Hepatol. 2013; 25(3): 593–608. CrossRef Google Scholar

The objective of the study was to compare polygraphic parameters and selected laboratory in patients with obstructive sleep apnoea (OSA) who develop various types left ventricular (LV) geometry. Material Methods. research covered 122 coexisting effectively treated systemic hypertension (95 men, 27 women, average age: 54 ± 10.63). Overnight polygraphy, echocardiography, carotid artery ultrasonography, measurements were performed. classified into four groups, depending on LV Group 1 comprised...

1. Bosetti C, Levi F, Lucchini Zatonski WA, Negri E, La Vecchia C. Worldwide mortality from cirrhosis: an update to 2002. J Hepatol. 2007; 46: 827–839. CrossRef Google Scholar

Pyoderma gangrenosum (PG) is a neutrophilic dermatosis of unknown origin. Clinically it starts with pustule, nodule or bulla that rapidly progresses and turns into painful ulcer raised, undermined borders. The etiopathogenesis PG remains unknown. However frequently associated systemic diseases such as inflammatory bowel disease (IBD), haematological disorders arthritis. latest multicentric retrospective analysis published by Ghazal et al. shows anaemia has been observed very often in German...