Betulin, a pentacyclic triterpene and plant metabolite, can be found in large quantities the outer bark of birches (Betula, Betulaceae). Betulinic acid, obtained by betulin oxidation, is also abundantly present nature. Both compounds show wide spectrum biological pharmacological properties, such as anti-HIV, anti-inflammatory, and, considered most important, anti-cancer. Although specific mechanism action against malignant cells still subject detailed research, activity acid has been linked...

Umbilical cord blood collected from the postpartum placenta and is a rich source of hematopoietic stem cells (HSCs) an alternative to bone marrow transplantation. In this review we wanted describe differences (in phenotype, cytokine production, quantity quality cells) between umbilical blood, peripheral blood. HSCs present in are more primitive than their counterparts or have several advantages including high proliferation. With using proper combination, can be effectively developed into...

1. Breitmaier E. Terpenes: Importance, General Structure, and Biosynthesis. 2006. Google Scholar

BACKGROUND The fast pace of life, promoting food consumption and low physical activity, has resulted in obesity and/or diabetes as being serious social problems. aim the present study was to evaluate concentrations selected adipokines (leptin, adiponectin, resistin, visfatin) assess leptin/adiponectin ratio plasma type 2 (T2D) patients relation degree obesity. MATERIAL AND METHODS comprised 92 T2D subjects divided into 4 groups according BMI value - I (normal body weight), II (overweight),...

Drug resistance has become a major concern in the field of infection management, therefore searching for new antibacterial agents is getting more challenging. Our study presents an optimized and eco-friendly synthesis scheme panel nitroalkenes bearing various functional groups aromatic moiety bromine or cyano substituents 1 position nitrovinyl moiety. The presence nitrolefine group outside ring minimalizes genotoxic properties while conjugation aryl with increases stability compounds. Then...

Seventeen adamantane derivatives were synthesized according to facile condensation reaction protocols. Spectral analysis (1H NMR and 13C NMR) was applied confirm the chemical structure of obtained substances. The compounds tested for in vitro antimicrobial activity against a panel Gram-positive Gram-negative bacterial strains towards fungi from Candida spp. Among them, four numbered 9, 14, 15 19 showed highest antibacterial potential with MIC = 62.5–1000 µg/mL respect all bacteria. S....

The overuse of antibiotics is one the reasons which has led to development drug‐resistant bacteria, a huge challenge for modern medicine. As well as incidences cancer are increasing every year. Currently known cytostatics do not provide satisfactory therapeutic effects with many side effects. Bearing in mind these problems medicine, we have synthesized new acylhydrazones potential antibacterial and anticancer activity. compounds were created result condensation commercially available...

This study presents the synthesis, antiproliferative and antimicrobial evaluation of a new series Mannich base derivatives containing 1,2,4-triazole system. New compounds were prepared by reaction 4,5-disubstituted 1,2,4-triazole-3-thiones with formaldehyde various amines. The structures confirmed means 1H NMR, 13C NMR elemental analyses. Twelve evaluated for their in vitro activities against six chosen cancer cell lines. All synthesized screened activity using agar dilution technique. For...

Postmenopausal women more often suffered from knee osteoarthritis and its pathogenesis still remains unclear. Calcium silicon are significant elements involved in bone joint metabolism, especially older people. Cardiovascular diseases common worldwide simvastatin is the most prescribed drug such population of patients. The purpose this study was to evaluate effect administration on calcium concentration plasma postmenopausal with osteoarthritis. Sixty mild hypercholesterolemic (mean age 61.4...

Silver birch, Betula pendula Roth, is one of the most common trees in Europe. Due to its content many biologically active substances, it has long been used medicine and cosmetics, unlike rare black obscura Kotula. The aim study was therefore compare antioxidant properties extracts from inner outer bark layers both birch towards L929 line treated with acetaldehyde. Based on lactate dehydrogenase test MTT test, 10 25% concentrations were selected for evaluation. All at tested reduced...

Objective Our objective was to evaluate the state of oxidative stress in great saphenous varicose vein wall and blood patients taken from antecubital vein. Methods The superoxide dismutase, reduced glutathione (GSH) total antioxidant status were measured with commercially available colorimetric kits erythrocytes, plasma 65 (second degree clinical classification, etiology, anatomy pathophysiology) aged 22-70 (49 women, 16 men) comparison normal walls collected 10 who underwent coronary artery...

Abstract Currently, little data exists regarding the involvement of free amino acids (AA) in pathogenesis ischemic stroke (IS). Thus, our objective was to study degree fluctuation level serum during acute phase IS. The consisted eighteen patients (female/male: 10/8; age: 73.1 ± 4.1) with IS that confirmed by way computed tomography, while twelve sex and age matched individuals were assigned as control group. During period, did not receive any supplemental therapy could affect obtained...

Abstract Background Increased blood pressure in the varicose veins (VV) can contribute to overexpression of matrix metalloproteinases (MMPs), affecting endothelium, smooth muscle, and extracellular vein wall. Gelatinases (MMP-2 MMP-9), hypoxia, inflammation occurring VV wall increased expression vascular endothelial growth factor (VEGF). Aims Our objective was analyze concentration gelatinases VEGF great saphenous plasma patients. Methods In total, 65 patients (2nd degree according clinical...

Electric cell–substrate impedance sensing is an advanced in vitro measuring system which uses alternating current to determine behavior of cells physiological conditions. In this study, we used the abovementioned method for checking anticancer activities betulin and betulinic acid, are some most commonly found triterpenes nature. our experiment, threshold concentrations required elicit antiproliferative effects, verified by MTT LDH release methods, were 7.8 µM breast cancer (T47D), 9.5 lung...

The aim of our study was the two-stage synthesis 1,3,4-oxadiazole derivatives. first step hydrazide–hydrazones from 3-methyl-4-nitrobenzhydrazide and corresponding substituted aromatic aldehydes. Then, synthesized were cyclized with acetic anhydride to obtain new 3-acetyl-2,3-disubstituted-1,3,4-oxadiazolines. All obtained compounds tested in vitro assays establish their potential antimicrobial activity cytotoxicity. Our results indicated that few newly had some activity, mainly 20 37...

Antibiotic resistance is now a global problem, and the lack of effective antimicrobial agents for treatment diseases caused by resistant microbes increasing. The 3-acetyl-2,5-disubstituted-1,3,4-oxadiazolines presented in this article may provide good starting point development potential new useful bacterial fungal infections. Particular attention drawn to 1,3,4-oxadiazole derivative marked with number 29 5-nitrofuran-2-yl substituent its chemical structure. This substance showed strong...

There is no information about possible effect of recombinant tissue plasminogen activator (rtPA) therapy on excitotoxic/neuroprotective amino acids during acute phase ischaemic stroke (IS). Our purpose was to evaluate iv thrombolytic treatment glutamate (Glu) and gamma-aminobutyric acid (GABA) serum levels IS. Eleven (rtPA group) 12 non-thrombolytic (non-rtPA patients with IS were enrolled. The samples obtained at three time points for rtPA group (time point 0: first fourth hour stroke; 1:...