A5038478068- Genomics and Phylogenetic Studies
- Zoonotic diseases and public health
- Enterobacteriaceae and Cronobacter Research
- RNA and protein synthesis mechanisms
- Microbial Community Ecology and Physiology
- Coffee research and impacts
- Chromosomal and Genetic Variations
- Bacteriophages and microbial interactions
- Gut microbiota and health
- Public Health and Nutrition
- Advanced biosensing and bioanalysis techniques
- Legume Nitrogen Fixing Symbiosis
ZOE (United Kingdom)
2024
Wellcome Sanger Institute
2016-2018
Diet impacts human health, influencing body adiposity and the risk of developing cardiometabolic diseases. The gut microbiome is a key player in diet-health axis, but while its bacterial fraction widely studied, role micro-eukaryotes, including Blastocystis, underexplored. We performed global-scale analysis on 56,989 metagenomes showed that Blastocystis exhibits distinct prevalence patterns linked to geography, lifestyle, dietary habits. presence defined specific signature was positively...
Long-read sequencing technologies such as Pacific Biosciences and Oxford Nanopore MinION are capable of producing long reads with average fragment lengths over 10,000 base-pairs maximum reaching 100,000 base- pairs. Compared short reads, the assemblies obtained from long-read platforms have much higher contig continuity genome completeness fragments able to extend paths into problematic or repetitive regions. Many successful assembly applications technology been reported ranging small...
Transmissible cancers are clonal lineages that spread through populations via contagious cancer cells. Although rare in nature, two facial tumor clones affect Tasmanian devils. Here we perform comparative genetic and functional characterization of these lineages. The have similar patterns mutation show no evidence exposure to exogenous mutagens or viruses. Genes encoding PDGF receptors copy number gains present on extrachromosomal double minutes. Drug screening indicates causative roles for...
Abstract Although diet is a substantial determinant of the human gut microbiome, interplay between specific foods and microbial community structure remains poorly understood. Coffee habitually consumed beverage with established metabolic health benefits. We previously found that coffee is, among >150 items, food showing highest correlation microbiome components. Here we conducted multi-cohort, multi-omic analysis US UK populations detailed dietary information from total 22,867...
The recent technological advances in genome sequencing techniques have resulted an exponential increase the number of sequenced human and non-human genomes. ever increasing assemblies generated by novel de novo pipelines strategies demands development new software to evaluate assembly quality completeness. One way determine completeness is detecting its Presence-Absence variations (PAV) with respect a reference, where PAVs between two are defined as sequences present one but entirely missing...