A5070357105- Gut microbiota and health
- Infant Nutrition and Health
- COVID-19 Impact on Reproduction
- Breastfeeding Practices and Influences
- Infant Health and Development
- Diet and metabolism studies
- Nutritional Studies and Diet
- Pediatric health and respiratory diseases
- Selenium in Biological Systems
- Birth, Development, and Health
- Probiotics and Fermented Foods
- Clostridium difficile and Clostridium perfringens research
- Respiratory viral infections research
- Neonatal Respiratory Health Research
- SARS-CoV-2 and COVID-19 Research
- Food Security and Health in Diverse Populations
- Vaccine Coverage and Hesitancy
- Reproductive tract infections research
- Gastrointestinal motility and disorders
- Sperm and Testicular Function
- Diabetes and associated disorders
- Genomics and Phylogenetic Studies
- Dietary Effects on Health
- Tryptophan and brain disorders
- Gestational Diabetes Research and Management
Instituto de Agroquímica y Tecnología de Alimentos
2017-2025
Consejo Superior de Investigaciones Científicas
2017-2024
University of Trento
2022-2024
Weatherford College
2020
Universitat de València
2020
There is increasing evidence for the interaction between gut microbiome, diet, and health. It known that dysbiosis related to disease most of times this imbalances in microbial populations can be promoted through diet. Western dietary habits, which are characterized by high intakes calories, animal proteins, saturated fats, simple sugars have been linked with higher risk obesity, diabetes, cancer, cardiovascular disease. However, little about impact patterns, components, nutrients on...
Abstract The human microbiome is an integral component of the body and a co-determinant several health conditions 1,2 . However, extent to which interpersonal relations shape individual genetic makeup its transmission within across populations remains largely unknown 3,4 Here, capitalizing on more than 9,700 metagenomes computational strain-level profiling, we detected extensive bacterial strain sharing individuals (more 10 million instances) with distinct mother-to-infant, intra-household...
The composition and maturation of the early-life microbiota are modulated by a number perinatal factors, whose interplay in relation to microbial vertical transmission remains inadequately elucidated. Using recent strain-tracking methodologies, we analyzed mother-to-infant two different birth environments: hospital-born (vaginal/cesarean) home-born (vaginal) infants their mothers. While delivery mode primarily explains initial compositional differences, place impacts timing-being early...
Abstract Cognitive decline, obesity and gut dysfunction or microbial dysbiosis occur in association. Our aim was to identify microbiota-metabolomics signatures preceding dementia genetically prone (3xtg) mice, with without superimposed high-fat diet. We examined the composition diversity of their microbiota, serum faecal metabolites. 3xtg mice showed brain hypometabolism typical pre-demented stage, lacked physiological bacterial between caecum colon seen controls. Cluster analyses revealed...
Nutrition during pregnancy plays an important role in maternal-neonatal health. However, the impact of specific dietary components on maternal gut microbiota and potential effects neonatal infant health outcomes short term are still limited. A total 86 mother-neonate pairs were enrolled this study. Gut profiling stool samples at birth was carried out by 16S rRNA gene sequencing using Illumina. Maternal information clinical anthropometric data recorded first 18 months. Longitudinal Body Mass...
Breast milk is a complex biofluid that provides nutrients and bioactive agents, including bacteria, for the development of infant gut microbiota. However, impact maternal diet other factors, such as mode delivery antibiotic exposure, on breast microbiota has yet to be understood. This study aimed examine association between ascertain potential role exposure. In cross-sectional MAMI cohort, profiling was assessed in 120 samples from healthy mothers by 16S rRNA gene sequencing. Maternal...
Objectives To develop and validate a specific protocol for SARS-CoV-2 detection in breast milk matrix to determine the impact of maternal infection on presence, concentration persistence antibodies. Design patients This is prospective, multicentre longitudinal study (April–December 2020) 60 mothers with and/or who have recovered from COVID-19. A control group 13 women before pandemic were also included. Setting Seven health centres different provinces Spain. Main outcome measures Presence...
Early microbial colonization triggers processes that result in intestinal maturation and immune priming. Perinatal factors, especially those associated with birth, including both mode place of delivery are critical to shaping the infant gut microbiota potential health consequences.Gut profile 180 healthy infants (n = 23 born at home n 157 hospital, 41.7% via cesarean section [CS]) was analyzed by 16S rRNA gene sequencing 7 days, 1 month life. Breastfeeding habits clinical data, length,...
<h3>Importance</h3> Being born small for gestational age (SGA) is a leading cause of perinatal morbidity and mortality with no effective prevention or therapy. Maternal suboptimal nutrition high stress levels have been associated poor fetal growth adverse pregnancy outcomes. <h3>Objective</h3> To investigate whether structured interventions based on Mediterranean diet mindfulness-based reduction (stress reduction) in high-risk pregnancies can reduce the percentage newborns who were SGA other...
Breast milk is a vehicle to transfer protective antibodies from the lactating mother neonate. After SARS-CoV-2 infection, virus-specific IgA and IgG have been identified in breast milk, however, there are limited data on impact of different COVID-19 vaccine types women. This study aimed evaluate time course induction SARS-CoV-2-specific after vaccination.
Background and aimsWe aimed to describe characterize the gut microbiota composition diversity in children with obesity according their metabolic health status.MethodsAnthropometry, Triglycerides, HDL cholesterol, HOMA-IR, systolic diastolic blood pressure (SBP, DBP) were evaluated (and z-score calculated) faecal samples collected from 191 aged 8 14. All classified depending on cardiometabolic status either a "metabolically healthy" (MHO; n = 106) or unhealthy" (MUO; 85) group. Differences...
Abstract Although diet is a substantial determinant of the human gut microbiome, interplay between specific foods and microbial community structure remains poorly understood. Coffee habitually consumed beverage with established metabolic health benefits. We previously found that coffee is, among >150 items, food showing highest correlation microbiome components. Here we conducted multi-cohort, multi-omic analysis US UK populations detailed dietary information from total 22,867...
Selenium (Se) is a micronutrient involved in important health functions and it has been suggested to shape gut microbiota. Limited information on Se assimilation by microbes the possible link with selenoproteins are available. For this purpose, conventional microbiota-depleted BALB/c mice were fed Se-supplemented diet. The absolute quantification of plasma was performed for first time using heteroatom-tagged proteomics. microbiota profile analyzed 16S rRNA gene sequencing. Se-supplementation...
Human milk oligosaccharides (HMOs) are complex glycans that abundant in human milk. The potential impact of a maternal diet on individual HMOs and the association with secretor status is unknown. Thus, this study aimed to examine between HMO profiles.
Abstract Selenium is a well-known essential element with important roles in human reproductive health mainly due to its antioxidant character. This study aimed investigate the potential role of selenoproteins on gut microbiota and male health. A new assay for absolute quantification testicular tissue based two dimensional chromatography inductively coupled plasma mass spectrometry was performed first time. The profile obtained by 16S rRNA gene sequencing. Numerous associations were found...
The human microbiome seeding starts at birth, when pioneer microbes are acquired mainly from the mother. Mode of delivery, antibiotic prophylaxis, and feeding method have been studied as modulators mother-to-infant transmission, but other key influencing factors like modern westernized lifestyles with high hygienization, high-calorie diets, urban settings, compared non-westernized not investigated yet. In this study, we explored mother-infant sharing characterized uncharacterized members via...
Early microbial colonization is a relevant aspect in human health. Altered patterns have been linked to an increased risk of non-communicable diseases (NCDs). Advances understanding host-microbe interactions highlight the pivotal role maternal microbiota on infant health programming. This birth cohort aimed characterize microbes transferred neonates during first 1000 days life, as well identify potential host and environmental factors, such gestational age, mode delivery, maternal/infant...
Abstract An elevated number of women reproductive age are overweight, predisposing their offspring to metabolic and neuropsychiatric disorders. Gut microbiota is influenced by maternal factors, has been implicated in the pathogenesis neurodegenerative diseases. Our aim was explore effects high-fat feeding on relationship linking gut cognitive development offspring. Murine born dams undergoing normal diet (NDm) (HFDm) were studied at 1 or 6 months assess function Y-maze test, cerebral glucose...
Breastfeeding is critical for adequate neonatal microbial and immune system development affecting neonate health outcomes in the short long term. There a great interest ascertaining which are maternal factors contributing to milk microbiota potential relevance developing infant. Thus, our study aimed characterize effect of mixed exclusive breastfeeding practices on determine impact pre-pregnancy body mass index (BMI) weight gain over pregnancy its composition. Breast samples from 136 healthy...
The fatty acid (FA) composition of breast milk is a relevant aspect related to the development lactating infant. present study aimed at exploring correlations between dietary intake macro- and micronutrients with FA profile in milk, possible implication for infants' growth.Breast samples from cohort women were collected 7-15 days postpartum. profiles triacylglycerol (TAG) phospholipid (PL)-rich fractions analyzed by gas chromatography. Diet was registered during third trimester pregnancy...