A5061965126- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Prenatal Screening and Diagnostics
- COVID-19 Impact on Reproduction
- Maternal Mental Health During Pregnancy and Postpartum
- Fetal and Pediatric Neurological Disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Neonatal Respiratory Health Research
- Maternal and fetal healthcare
- Congenital Heart Disease Studies
- Cardiovascular Issues in Pregnancy
- Neonatal and fetal brain pathology
- Nutritional Studies and Diet
- COVID-19 and healthcare impacts
- Child Nutrition and Feeding Issues
- Preterm Birth and Chorioamnionitis
- Diet and metabolism studies
- Domain Adaptation and Few-Shot Learning
- Reproductive System and Pregnancy
- Congenital Diaphragmatic Hernia Studies
- Infant Development and Preterm Care
- Breastfeeding Practices and Influences
- Ectopic Pregnancy Diagnosis and Management
- Pregnancy and Medication Impact
Hospital Sant Joan de Déu Barcelona
2016-2025
Universitat de Barcelona
2016-2025
Institut de Recerca Sant Joan de Déu
2020-2025
Instituto de Salud Carlos III
2020-2025
Sant Joan de Déu Research Foundation
2023-2025
Red de Investigación en Actividades Preventivas y Promoción de la Salud
2022-2025
Hospital Clínic de Barcelona
2014-2025
Centre for Biomedical Network Research on Rare Diseases
2015-2024
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2012-2024
Pontificia Universidad Javeriana
2023
Abstract Objective To develop an integrated model with the best performing criteria for predicting adverse outcome in small‐for‐gestational‐age ( SGA ) pregnancies. Methods A cohort of 509 pregnancies a suspected fetus, eligible trial labor, was recruited prospectively and data on perinatal were recorded. predictive emergency Cesarean delivery because non‐reassuring fetal status or neonatal acidosis constructed using decision tree analysis algorithm, predictors: maternal age, body mass...
Abstract Objective The aim of this article is to develop the best first‐trimester screening model for preeclampsia (PE) based on maternal characteristics, biophysical parameters, and angiogenic factors in a low‐risk population. Methods A prospective cohort 9462 pregnancies undergoing used. Logistic regression predictive models were developed early late PE (cut‐off 34 weeks' gestation at delivery). Data included priori risk (maternal characteristics), mean arterial pressure (MAP), uterine...
Abstract Background We performed a population-based study to describe the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on pregnancy outcomes. Methods This prospective, included pregnant women who consecutively presented at first/second trimester visits or delivery 3 hospitals in Barcelona, Spain. SARS-CoV-2 antibodies (immunoglobulin [Ig] G and IgM/IgA) were measured all participants, nasopharyngeal real-time polymerase chain reaction (RT-PCR) was...
To develop optimal first-trimester algorithms for the prediction of early and late fetal growth restriction (FGR).This was a prospective cohort study singleton pregnancies undergoing screening. FGR defined as an ultrasound estimated weight < 10(th) percentile plus Doppler abnormalities or birth 3(rd) percentile. Logistic regression-based predictive models were developed predicting (cut-off: delivery at 34 weeks). The model included a-priori risk (maternal characteristics), mean arterial...
Objectives To develop and validate a specific protocol for SARS-CoV-2 detection in breast milk matrix to determine the impact of maternal infection on presence, concentration persistence antibodies. Design patients This is prospective, multicentre longitudinal study (April–December 2020) 60 mothers with and/or who have recovered from COVID-19. A control group 13 women before pandemic were also included. Setting Seven health centres different provinces Spain. Main outcome measures Presence...
<h3>Importance</h3> Being born small for gestational age (SGA) is a leading cause of perinatal morbidity and mortality with no effective prevention or therapy. Maternal suboptimal nutrition high stress levels have been associated poor fetal growth adverse pregnancy outcomes. <h3>Objective</h3> To investigate whether structured interventions based on Mediterranean diet mindfulness-based reduction (stress reduction) in high-risk pregnancies can reduce the percentage newborns who were SGA other...
Abstract Introduction Prematurity is a major global health issue. Twin pregnancies are group at especially high risk of preterm birth. Sonographic mid‐trimester cervical length has limited accuracy in predicting This study aimed to evaluate the association between sonographic markers early remodeling and inflammatory biomarkers fetal fibronectin, alone or combination, as predictors birth before 34+0 weeks asymptomatic twin pregnancies. Material Methods Prospective cohort study, including...
To assess the usefulness of circulating microRNAs (miRNAs) as non-invasive molecular biomarkers for early prediction preeclampsia, a differential miRNA profiling analysis was performed in first-trimester pooled sera from 31 preeclampsia patients, requiring delivery before 34 weeks gestation and 44 uncomplicated pregnancies using microfluidic arrays. Among total 754 miRNAs analyzed, presence 63 (8%) consistently documented control samples. Nevertheless, only 15 amplified (2%) seemed to be...
To assess the effectiveness of first-trimester screening for early and late small-for-gestational-age (SGA) neonates using maternal serum biochemistry, blood pressure uterine artery Doppler.This was a prospective study 4970 women with singleton pregnancy who underwent routine between 2009 2011. A logistic regression-based predictive model SGA, defined as birth weight < 10(th) percentile, divided into early- or late-onset based on gestational age at delivery before after 34 weeks' gestation,...
Objective To elucidate the association between Doppler parameters and histological signs of placental underperfusion in late-onset small-for-gestational-age (SGA) babies. Methods Umbilical, fetal middle cerebral uterine artery pulsatility indices umbilical vein blood flow (UVBF), which had been recorded within 7 days prior to delivery, were analyzed from a cohort SGA singleton pregnancies delivered after 34 weeks' gestation confirmed as having birth weight < 10th percentile by local...
Preeclampsia is a pregnancy-specific multisystem disorder and leading cause of maternal perinatal morbidity mortality. The exact pathogenesis this multifactorial disease remains poorly defined. We applied proteomics analysis on blood samples collected from 14 singleton pregnancies with early-onset severe preeclampsia 6 uncomplicated to investigate the pathophysiological pathways involved in specific subgroup preeclampsia. Maternal was drawn at diagnosis for cases matched gestational age...
COVID-19 presents a spectrum of signs and symptoms in pregnant women that might resemble preeclampsia. Differentiation between severe preeclampsia is difficult some cases.To study biomarkers endothelial damage, coagulation, innate immune response, angiogenesis pregnancy addition to vitro alterations cells exposed sera from with COVID-19.Plasma samples were obtained infection classified into mild (n=10) or (n=9) normotensive pregnancies as controls patients (n=13). A panel plasmatic was...
ABSTRACT Objectives To compare the value of Doppler surveillance with maternal blood angiogenic factors at diagnosis for prediction adverse outcome in late‐pregnancy small‐for‐gestational‐age ( SGA ) fetuses. Methods In a cohort 198 fetuses we evaluated association indices (mean uterine artery pulsatility index UtA‐PI and cerebroplacental ratio CPR )) (maternal serum levels soluble fms‐like tyrosine kinase‐1 sFlt ‐1) placental growth factor PlGF development pre‐eclampsia perinatal (operative...
To investigate whether signs of placental underperfusion (PUP), defined as any maternal and/or fetal vascular pathology, confer an increased risk neonatal morbidity in late-onset small-for-gestational-age (SGA) fetuses with normal umbilical artery (UA) Doppler indices.A cohort 126 SGA singleton UA indices that were delivered after 34 weeks' gestation was studied. For each case, the placenta evaluated histologically for PUP using a hierarchical and standardized classification system. Neonatal...
To compare umbilical vein (UV) flow with standard Doppler parameters in prediction of adverse perinatal outcome late-onset small-for-gestational age (SGA) fetuses.Umbilical, uterine and middle cerebral arteries, UV blood were evaluated by before delivery a cohort 193 term SGA fetuses. The value the to predict risk emergency for non-reassuring fetal status neonatal metabolic acidosis was analyzed.Fifty-three (27%) fetuses had requiring delivery, whereas 21 (11%) newborns developed acidosis....
To perform a comprehensive assessment of the placental aging process in small term fetuses classified as being small-for-gestational age (SGA) or having fetal growth restriction (FGR) through analysis senescence and apoptosis markers.This was prospective nested case-control study singleton pregnancies delivered at term, including 21 control with normally grown 36 fetus SGA (birth weight between 3rd 9th percentiles normal fetoplacental Doppler; n = 18) FGR < percentile and/or abnormal...
To assess the ability of integrated first-trimester screening, combining maternal characteristics and biophysical biochemical markers, to predict delivery a small-for-gestational-age (SGA) neonate, compare this with its fetal growth restriction (FGR).This was prospective cohort study singleton pregnancies undergoing routine screening. SGA defined as birth weight (BW) < 10th percentile FGR an ultrasound estimated plus Doppler abnormalities, or BW 3rd percentile. Logistic regression-based...
To compare the performance of third-trimester screening, based on estimated fetal weight centile (EFWc) vs a combined model including maternal baseline characteristics, fetoplacental ultrasound and biochemical markers, for prediction small-for-gestational-age (SGA) neonates late-onset growth restriction (FGR).This was nested case-control study within prospective cohort 1590 singleton gestations undergoing (32 + 0 to 36 6 weeks' gestation) evaluation. Maternal mean arterial pressure,...
To describe placental histopathological findings in a large cohort of pregnancies complicated by pre-eclampsia (PE) and/or small-for-gestational age (SGA), and to investigate their association with fetoplacental Doppler parameters.This was prospective observational study normotensive SGA (defined as birth weight < 10th centile) (n = 184), PE normally grown fetus 102), both 120) uncomplicated 202). Uterine (UtA), umbilical (UA) fetal middle cerebral (MCA) artery pulsatility indices (PI) were...