A5025685921- Congenital Heart Disease Studies
- Cardiovascular Issues in Pregnancy
- Cardiac Arrhythmias and Treatments
- Pregnancy and preeclampsia studies
- Cardiovascular Function and Risk Factors
- Cytomegalovirus and herpesvirus research
- Cardiac Valve Diseases and Treatments
- COVID-19 Impact on Reproduction
- Parvovirus B19 Infection Studies
- Congenital heart defects research
- Congenital Diaphragmatic Hernia Studies
- COVID-19 and healthcare impacts
- Assisted Reproductive Technology and Twin Pregnancy
- Ectopic Pregnancy Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Pregnancy-related medical research
- Pulmonary Hypertension Research and Treatments
- Prenatal Screening and Diagnostics
- Gestational Diabetes Research and Management
- Health, Education, and Physical Culture
- Preterm Birth and Chorioamnionitis
- Maternal Mental Health During Pregnancy and Postpartum
- Higher Education Teaching and Evaluation
- HIV-related health complications and treatments
- Herpesvirus Infections and Treatments
Hospital Sant Joan de Déu Barcelona
2016-2025
Sant Joan de Déu Research Foundation
2025
Institut de Recerca Sant Joan de Déu
2025
Universitat de Barcelona
2014-2022
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2014-2022
Centre for Biomedical Network Research on Rare Diseases
2017-2021
Centro de Investigación Biomédica en Red
2020
Abstract Introduction Prematurity is a major global health issue. Twin pregnancies are group at especially high risk of preterm birth. Sonographic mid‐trimester cervical length has limited accuracy in predicting This study aimed to evaluate the association between sonographic markers early remodeling and inflammatory biomarkers fetal fibronectin, alone or combination, as predictors birth before 34+0 weeks asymptomatic twin pregnancies. Material Methods Prospective cohort study, including...
<b><i>Objective:</i></b> There is a need for standardized reference values cardiac dimensions in prenatal life. The objective of the present study was to construct nomograms fetal using well-defined echocardiographic methodology low-risk population. <b><i>Methods:</i></b> This prospective cohort including 602 singleton pregnancies undergoing echocardiography accurately assess cardiac, ventricular, and atrial dimensions. Parametric regressions...
To construct nomograms for fetal cardiac, ventricular and atrial relative size geometry parameters from 18 to 41 weeks' gestation using a low-risk population of singleton pregnancies.This was prospective cohort study 602 pregnancies undergoing comprehensive echocardiography, weeks gestation, assess sphericity, dominance, wall asymmetry thickness. Intra- interobserver measurement reproducibility evaluated intraclass correlation coefficients (ICC). In order reference ranges across pregnancy,...
Introduction Congenital cytomegalovirus (cCMV) is the main infectious cause of sensorineural hearing loss and neurodevelopmental disability. First-trimester periconceptional period are most vulnerable times for fetal injury. Universal serological (CMV) screening in pregnant women not currently recommended. After a recent randomized controlled clinical trial that demonstrated 70% reduction vertical transmission with high-dose valacyclovir (VCV), pilot first-trimester program was launched at...
Objective The objective of this study is to measure aortic intima-media thickness (aIMT) and diameter (AD) in appropriate for gestational age (AGA) fetuses, small (SGA) intrauterine growth restricted (IUGR) fetuses. Methods Case-control performed between June 2011 2012. Forty-nine AGA 40 SGA 35 IUGR fetuses underwent concomitant measurement aIMT AD at a mean 34.4 weeks. Results Median was higher with (0.504 mm [95%CI: 0.477-0.530 mm]), than (0.466 [95% CI: 0.447–0.485 (0.471 0.454-0.488 mm])...
Cytomegalovirus (CMV) is a major cause of childhood disabilities, and consensus recommendations emphasize the importance hygienic measures to reduce perinatal infection. Our study aimed evaluate level awareness about CMV among health professionals pregnant women.We submitted 20-item online survey regarding infection all obstetricians midwives in Catalonia (Spain) 7-item lay version questionnaire 700 women. Levels knowledge were compared groups.Of 1,449 approached, 338 surveys answered. 72%...
ABSTRACT Objectives To define the pattern of fetal echocardiographic changes associated with isolated pulmonary valve stenosis (PS) and to correlate findings neonatal outcome need for postnatal valvuloplasty within first 12 months postpartum. Methods This was a prospective cohort study between January 2009 October 2015 16 fetuses PS 48 controls matched by gestational age at ultrasound examination (± 2 weeks) evaluated Fetal Cardiology Unit BCNatal (Barcelona). Standard comprehensive...
ABSTRACT Objectives Coarctation of the aorta (CoA) is associated with left ventricular (LV) dysfunction in neonates and adults. Cardiac structure function fetal CoA cardiac adaptation to early neonatal life have not been described. We aimed investigate presence cardiovascular structural remodeling fetuses their postnatal adaptation. Methods This was a prospective observational case–control study, conducted between 2011 2018 single tertiary referral center, gestational age‐matched normal...
<b><i>Objectives:</i></b> Fetal right ventricular (RV) function assessment is challenging due to the RV geometry and limitations of in utero assessment. Postnatally, 2D echocardiographic fractional area change (FAC) used assess global systolic by calculating percentage from systole diastole. Reports on FAC are scarce prenatal life, nomograms throughout pregnancy not available. Our aims were (1) study feasibility reproducibility (2) construct for end-diastolic (ED)...
We aimed to assess the postnatal pattern of cardiovascular remodeling associated with intrauterine exposure maternal HIV and antiretroviral treatment (ART).Prospective cohort including 34 HIV-exposed uninfected (HEU) infants 53 non-HIV-exposed were evaluated from fetal life up 6 months postnatally. A evaluation was performed echocardiography, blood pressure, carotid intima media thickness (cIMT) measurement.ART regimens during pregnancy included 2 nucleoside reverse transcriptase inhibitors...
Fetal cardiac function can be evaluated using a variety of parameters. Among these, cycle time-related parameters, such as filling time fraction (FTF) and ejection (ETF), are promising but rarely studied. We aimed to report the feasibility reproducibility fetal FTF ETF measurements pulsed-wave Doppler, provide reference ranges for ETF, after evaluating their relationship with heart rate (HR), gestational age (GA) estimated weight (EFW), evaluate potential clinical utility in selected...
M-mode and 2D have been proposed for evaluating fetal myocardial thickness. However, studies comparing the performance of both modalities are lacking. We aimed to compare versus reproducibility assessing wall thicknesses.A prospective study including 45 healthy fetuses from low-risk pregnancies evaluated between 18 41 weeks gestation. Left right ventricular free-wall septal thicknesses were measured at end-diastole (ED) end-systole (ES) in transverse 4-chamber view using M-mode. Intra-...
Preterm prelabour rupture of membranes (PPROMs) before viability carries significant perinatal mortality and morbidity. Clinical management prenatal counselling are a challenge, especially in twin pregnancies, due to scarce evidence on how previable PPROM affects this population. The aim study was describe pregnancy outcomes pregnancies complicated with evaluate potential prognostic factors that may predict mortality. A retrospective cohort including dichorionic monochorionic diamniotic 24 +...
Currently, there is no validated treatment for fetal cytomegalovirus (CMV). Two studies suggest that high-dose maternal valacyclovir decreases viral load and improves outcomes in moderately-symptomatic fetuses. We offered cases of infection lacking ultrasound abnormalities or with non-severe infection. Maternal tolerability, outcome newborn blood were evaluated pregnancies mothers receiving valacyclovir.We performed a case series including 8 CMV classified as unaffected/mildly-moderately...
Abstract Objective Audit the crown‐rump length (CRL) measurements taken at 11 to 13 weeks scan, using operator‐specific median multiples of (MoM) for pregnancy‐associated plasma protein‐A (PAPP‐A) and free β ‐human chorionic gonadotropin ( ‐hCG) plots, identify deviations potentially related a systematic CRL bias. Methods Study population included consecutive singleton pregnancies undergoing first trimester combined screening, scanned by sonologists with least 100 scans, during 2011 2012...
Previous reports suggest that cord blood biomarkers could serve as a prognostic tool for conotruncal congenital heart defects (CHD). We aimed to describe the profile of different cardiovascular in prospective series fetuses with tetralogy Fallot (ToF) and D-transposition great arteries (D-TGA) explore their correlation fetal echocardiography perinatal outcome. Methods A cohort study (2014–2019), including isolated ToF D-TGA healthy controls, was conducted at two tertiary referral centers CHD...
To assess the impact of COVID-19 during pregnancy in terms fetal neurosonography (NSG) and its association with maternal severity gestational age at infection. Multicentric prospective cohort study including singleton pregnant women infection 5 hospitals Spain, from April 2020 to 2021. Maternal was confirmed by clinical symptoms, nasopharyngeal PCR, or serologic testing. Pregnancies were subdivided according disease NIH Classification. Fetal NSG performed once symptoms ceased, least 4 weeks...
The systolic (S) to diastolic (D) duration ratio (S/D) has been proposed as a useful index assess ventricular function in some pediatric cardiopathies. Prenatal reports on S/D are scarce and nomograms not available. We aimed establish normal values for left (LV) right (RV) ratios fetuses investigate its relation heart rate (HR), gestational age (GA) estimated fetal weight (EFW). Prospective cohort study including 602 low-risk singleton pregnancies (GA 18-41 weeks). Spectral Doppler signals...
Fetal echocardiography has limited prognostic ability in the evaluation of left-sided congenital heart defects (left defects). Cord blood cardiovascular biomarkers could improve left defects. A multicenter prospective cohort (2013−2019) including fetuses with (aortic coarctation, aortic stenosis, hypoplastic heart, and multilevel obstruction (complex defects) subdivided according to their outcome (favorable vs. poor), control were evaluated third trimester pregnancy at three referral centers...