A5023650040- Nitric Oxide and Endothelin Effects
- Neuropeptides and Animal Physiology
- Folate and B Vitamins Research
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Receptor Mechanisms and Signaling
- Sirtuins and Resveratrol in Medicine
- MicroRNA in disease regulation
- Risk Perception and Management
- Vagus Nerve Stimulation Research
- Lung Cancer Treatments and Mutations
- Essential Oils and Antimicrobial Activity
- Kruppel-like factors research
- Metabolism, Diabetes, and Cancer
- Vitamin K Research Studies
- Acupuncture Treatment Research Studies
- Gut microbiota and health
- Listeria monocytogenes in Food Safety
- Chronic Kidney Disease and Diabetes
- Vitamin C and Antioxidants Research
- Exercise and Physiological Responses
- Pharmacological Receptor Mechanisms and Effects
- Cardiac Ischemia and Reperfusion
- Esophageal Cancer Research and Treatment
- Heat shock proteins research
Army Medical University
2025
Zhejiang Center for Disease Control and Prevention
2012-2023
Shanghai University of Traditional Chinese Medicine
2022-2023
Qilu Hospital of Shandong University
2019-2022
Kaifeng University
2012
Harbin Institute of Technology
2010
State Key Laboratory of Microbial Technology
2009
The Ohio State University
2009
Shandong University
2009
Johns Hopkins University
1996-1998
A consensus treatment strategy for esophageal squamous cell carcinoma (ESCC) patients who recur after definitive radiochemotherapy/radiotherapy has not been established. This study compared the outcomes in ESCC underwent salvage surgery, chemoradiation (CRT) or best supportive care (BSC) local recurrence. Ninety-five with clinical stage I to III had completely responded initial radiochemotherapy radiotherapy alone and developed recurrence were enrolled this study. Fifty-one of them received...
Phloretin is a dihydrochalcone flavonoid from natural plants, which has protective activities against oxidative stress and inflammation. To date, its effect on diabetic nephropathy (DN) not been investigated. In this study, we examined the potential role of phloretin in diabetes-induced renal damage associated mechanisms type 2 diabetes mellitus (T2DM) model induced by streptozotocin (STZ) high-fat diet (HFD) Apolipoprotein E knockout (ApoE-/-) mice. We found that daily treatment with low...
High-intensity exercise (HIE) induces liver dysfunction and is detrimental to performance. The underlying mechanism preventive strategy urgently need be explored. We increased the amount of tryptophan appropriately in diet explored effect an L-tryptophan-rich on alleviation HIE-induced mechanism. In this work, by establishing a C57BL/6 mouse model high-intensity swimming exercise, results demonstrated significantly attenuated dysfunction, which was associated with levels metabolite...
Carbon nanotubes (CNTs) have many potential applications, including as delivery systems for a variety of diagnostic or therapeutic agents. However, it has been suggested that exposure to carbon nano-materials may be risk the development vascular diseases due its impact on endothelium.Male Sprague-Dawley rats (180-200 g) were used generate an atherosclerosis (AS) model, and effect intravenous administration multi-walled (MWCNTs) AS was studied. To further understand underlying mechanisms,...
ABSTRACT We investigated whether low-dose phloretin served as daily dietary supplements could ameliorate diabetic atherosclerosis and the role of kruppel-like factor 2 (KLF2). HUVECs cultured in high glucose medium were treated with different concentrations KLF2 mRNA, protein level was detected. Diabetes induced using streptozotocin Apoe−/- mice after which they fed a high-cholesterol diet for 8 weeks. Diabetic injected shRNA-lentivirus or control virus 20 mg/kg phloretin. Glucose, lipid...
Vitamin C (VC) is a key antioxidant of the Central Nervous System (CNS) and SLC23A2 (SVCT2) only transporter that actively transports VC into brain. While existing animal models deficiency are in whole body, essential role brain development remains elusive. In our study presented here, CRISPR/Cas9 technology was applied for construction C57BL/6J-SLC23A2 em1(flox)Smoc mouse model, which crossed with Glial fibrillary acidic protein-driven Cre Recombinase (GFAP-Cre) genotype mice to generate...
Retinal ischemia-reperfusion injury (RIRI) is the basis of pathology that leads to many retinal diseases and induces necroptosis apoptosis. Tumor necrosis factor-α (TNF-α) critically involved in Delta-opioid receptor (DOR) activation inhibits TNF-α release our previous studies, it might prevent apoptosis by inhibiting TNF-α. However, role DOR pigment epithelial (RPE) cells remains largely unknown. Here, we explored mechanisms using an oxygen-glucose deprivation/reoxygenation (OGD/R) model...
Objectives: Retinal ischemia-reperfusion injury (RIRI) is the common pathological basis of many ophthalmic diseases in later stages, and inflammation primary damage mechanism RIRI. Our study aimed to assess whether electroacupuncture (EA) has a protective effect against RIRI elucidate its related mechanisms. Methods: A high-intraocular pressure (HIOP) model was used simulate Wistar rats. EA applied EA1 group [Jingming (BL1) + Shuigou (GV26)] EA2 Hegu (LI4)] respectively for 30 min starting...
Iron deficiency (ID) is the biggest cause of anemia. This pilot study aimed to investigate effects food-derived oligopeptide iron chelates on ameliorating liver injury and restoring gut microbiota homeostasis in iron-deficiency anemia (IDA) female rats. Female Sprague-Dawley rats at 21 days old were selected randomly divided into a control group (N = 4) an ID model 16). The was fed iron-deficient diet containing 4 mg kg-1 for 28 generate IDA rat then subdivided four groups each group):...
Objective To study the effect of long-term operation a nuclear power plant (NPP) on population health,and to collect health related data around (NPP).Methods Four research areas,named 0-10 km area,10-20 area,20-30 area and control area,were set up interms distance from plant.Human blood samples were collected detect chromosome aberration lymphocytes subsets.Results The rates cells with at 0.157％,0.167％,0.070％ 0.111％,respectively.The differences in four areas not statistically significant.The...
Inducible nitric oxide synthase (iNOS) plays important roles in the process of myocardial infarction, heart failure, and cardiac preconditioning. The expression iNOS is mainly induced by inflammatory substances such as endotoxins cytokines. NF- κ B STAT-1 are two transcriptional factors that mediate stimulated cells. Previous studies showed heat shock protein 90 (Hsp90) associates with this association enhances activity. Here we show Hsp90 also essential for induction. To determine role...