A5017212564- Esophageal Cancer Research and Treatment
- Cancer-related molecular mechanisms research
- Natural product bioactivities and synthesis
- Transplantation: Methods and Outcomes
- Cancer, Hypoxia, and Metabolism
- Liver Disease and Transplantation
- Prostate Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Organ Transplantation Techniques and Outcomes
- Circular RNAs in diseases
- Renal cell carcinoma treatment
- Cancer Immunotherapy and Biomarkers
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Treatment and Research
- RNA modifications and cancer
- Hormonal and reproductive studies
- Traditional Chinese Medicine Studies
- Antioxidant Activity and Oxidative Stress
- Molecular Biology Techniques and Applications
- Inflammatory Biomarkers in Disease Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Genetic Associations and Epidemiology
- Endometrial and Cervical Cancer Treatments
- Ferroptosis and cancer prognosis
- Nutrition and Health in Aging
Sichuan Cancer Hospital
2020-2025
University of Electronic Science and Technology of China
2020-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2017-2024
Chongqing Medical University
2017-2024
Cancer Hospital and Research Institute
2022
Metabolic biomarkers are expected to decode the phenotype of gastric cancer (GC) and lead high-performance blood tests towards GC diagnosis prognosis. We attempted develop diagnostic prognostic models for based on plasma metabolic information.We conducted a large-scale, multicentre study comprising 1944 participants from 7 centres in retrospective cohort 264 prospective cohort. Discovery verification phases were through machine learning Cox regression fingerprints (PMFs) obtained by...
Sensitivity to neoadjuvant chemotherapy in locally advanced gastric cancer patients varies; however, an effective predictive marker is currently lacking. We aimed propose and validate a practical treatment efficacy prediction method based on contrast-enhanced computed tomography (CECT) radiomics. Data of l24 carcinoma who underwent were acquired retrospectively between December 2012 August 2020 from three different centers. In total, 1216 radiomics features initially extracted each lesion's...
The prognosis of renal cell carcinoma (RCC) varies greatly among different risk groups, and the traditional indicators have limited effect in identification grade patients with RCC. purpose our study is to explore a glycolysis-based long non-coding RNAs (lncRNAs) signature verify its potential clinical significance prognostic prediction RCC patients.In this study, RNA data information were downloaded from Cancer Genome Atlas (TCGA) database. Univariate multivariate cox regression displayed...
Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family, which functions as either tumor suppressor or prooncogenic factor in distinct types. Our research aimed to explore expression SFRP4 gastric cancer, its prognostic significance, and relationship with immune cell infiltration. Gastric cancer paracancerous tissue specimens from surgically resected patients were collected construct microarrays, immunohistochemistry was used detect SFRP4, PD-L1, CD3+ T, CD4+ CD8+ T these...
This study aimed to explore the prognostic value of preoperative red blood cell distribution width (RDW) in patients with metastatic renal carcinoma (mRCC).Clinicopathological data 230 mRCC treated at First Affiliated Hospital Chongqing Medical University and Chinese PLA General from January 2008 December 2018 were retrospectively analyzed. Patients stratified according optimal cut-off RDW calculated using X-tile software. The was analyzed Kaplan-Meier curve log-rank test univariate...
<title>Abstract</title> Ursolic acid (UA) is a natural compound that exists in number of Chinese medicinal herbs, which has been demonstrated to enhance the efficacy chemotherapy multiple types cancer. The present study aimed observe whether UA enhances antitumor effects gemcitabine (GEM) human bladder cancer (BCa) cell lines, and investigate possible underlying mechanisms. BCa T24 5637, were treated with GEM and/or vitro. Cell viability was measured by Counting Kit-8 assay. Apoptosis...
Hepatic ischemia reperfusion injury (IRI) is a continuous process of damage liver cells, which could cause series clinic reactions. Early owing to IRI, organ failure reaches 10%, and easily leads acute chronic transplantation rejection. Therefore, study on the treatment method IRI very important. Decreasing adverse effect significantly increase amount successful transplantation. This paper will explore mainly pretreatment methods IRI. Key words: Liver transplantation; Ischemia...
<title>Abstract</title> <bold>Background</bold> Gemcitabine (GEM) plays an important role in the chemotherapy of bladder cancer（BCa）. However, chemoresistance and adverse effects gemcitabine limit its effectiveness. Ursolic acid (UA) is a natural compound that exists many medicinal plants fruits, has been demonstrated to enhance efficacy multiple cancers. The present study aimed observe antitumor combination GEM UA human cancer cell lines, investigate possible underlying mechanisms....
Objective The aim of this research was to investigate the expression KLF2 and nuclear factor- kappa B P65(NF-κB P65) in hypothermic machine perfusion its role liver inflammatory response after rat transplantation from non-heart-beating donor. Methods Twelve rats were randomly divided into two groups: HMP group(n=6) cold storage (CS) group(n=6). With 30min hepatic pedicle occlusion, sacrificed obtained. group experienced CS for 3h, respectively. Using Isolated perfused model (IPRL)...
Abstract Background Hepatocellular carcinoma (HCC) is a common primary malignant tumor with an increasing incidence worldwide. Circular RNAs (circRNAs) have been demonstrated in playing significant roles the processes of physiology and pathology. However, expression patterns function circRNAs HCC remain unclear. Methods The circular RNA C3 (circC3) tissues, para-cancer tissues normal liver was detected by quantitative real-time polymerase chain reaction (qRT-PCR), their associations...