A5101680790- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Bone Metabolism and Diseases
- Bone health and treatments
- Ferroptosis and cancer prognosis
- Cancer Research and Treatments
- Endometrial and Cervical Cancer Treatments
- Water Quality Monitoring and Analysis
- Biosensors and Analytical Detection
- Head and Neck Cancer Studies
- Electrochemical Analysis and Applications
- RNA modifications and cancer
- Breast Cancer Treatment Studies
- Virus-based gene therapy research
- Plant Gene Expression Analysis
- Analytical chemistry methods development
- Marine Bivalve and Aquaculture Studies
- 14-3-3 protein interactions
- IL-33, ST2, and ILC Pathways
- Genomics, phytochemicals, and oxidative stress
- Genetically Modified Organisms Research
- Advanced Breast Cancer Therapies
- Ubiquitin and proteasome pathways
- Photodynamic Therapy Research Studies
Zhejiang Chinese Medical University
2021-2025
Gansu Agricultural University
2023-2025
Zhangzhou Municipal Hospital of Fujian Province
2014-2024
Fujian Medical University
2014-2024
Guangzhou Medical University
2024
Guangzhou First People's Hospital
2024
Nanchang University
2018-2022
Bruker (China)
2022
First Affiliated Hospital of Nanchang University
2018-2021
Zhejiang Provincial Hospital of TCM
2021
Combining immune checkpoint blockade (ICB) therapy with photodynamic (PDT) holds great potential in treating immunologically "cold" tumors, but photo-generated reactive oxygen species (ROS) can inevitably damage co-administered ICB antibodies, hence hampering the therapeutic outcome. Here we create a ROS-responsive hydrogel to realize sustained co-delivery of photosensitizers and antibodies. During PDT, skeleton poly(deca-4,6-diynedioic acid) (PDDA) protects antibodies by scavenging harmful...
Metabolic biomarkers are expected to decode the phenotype of gastric cancer (GC) and lead high-performance blood tests towards GC diagnosis prognosis. We attempted develop diagnostic prognostic models for based on plasma metabolic information.We conducted a large-scale, multicentre study comprising 1944 participants from 7 centres in retrospective cohort 264 prospective cohort. Discovery verification phases were through machine learning Cox regression fingerprints (PMFs) obtained by...
Abstract The incidence of adenocarcinoma the esophagogastric junction (AEG) has been rapidly increasing in recent decades, but its molecular alterations and subtypes are still obscure. Here, we conduct proteomics phosphoproteomics profiling 103 AEG tumors with paired normal adjacent tissues (NATs), whole exome sequencing 94 tumor-NAT pairs, RNA 83 pairs. Our analysis reveals an extensively altered proteome 252 potential druggable proteins tumors. We identify three proteomic significant...
The purpose of this study is to explore the expression miRNA-590-5p, an exosome gastric cancer (GC), and evaluate suitability miR-590-5p, with its own clinical characteristics. Serum samples from 168 patients 50 matched controls were collected exosomal RNAs extracted. After that, miR-590-5p analyzed by quantitative polymerase chain reaction (qRT-PCR), which more related pathological parameters patient monitoring data. MGC-803 HGC-27 cells treated mimics, then changes cell fluidity...
Histone methylation, which is regulated by histone methyltransferases (HMTs) and demethylases (HDMs), has been indicated to be involved in a variety of diseases, particularly cancer, including androgen‑independent prostate cancer (PCa). However, the functions HMTs HDTs have largely remained elusive. The present study, utilized an RNA interference screening using lentiviral small hairpin (sh)RNA library systematically elucidate function PCa cell growth viability. Nine HDTs, namely FBXO11,...
Rationale: Radical hysterectomy is the standard surgical procedure for early-stage cervical cancer, and postoperative adjuvant chemoradiotherapy administered based on pathological high-risk intermediate-risk factors. After treatment of all focus placed recurrence, metastasis menopausal symptoms, almost no one pays attention to recovery vaginal elasticity sexual activity reproductive-age women. Due frequent surgery radiation therapy cancer patients, length vagina are reduced. Cervical...
A novel ultrasensitive detection method utilizing surface‐enhanced Raman scattering (SERS) based on monolithic column was developed in the present study. Monolithic is a kind of chromatographic stationary phase that contains highly interconnected pores and absorbs chemical components efficiently. Dropping mixture solution containing analyte, silver colloid, NaCl surface advance, SERS signals were collected column. With this method, five commonly used probe molecules Rhodamine 6G (R6G), p...
Aging-related retinal degeneration can manifest as decreased visual function due to damage structures and dysfunction in homeostasis. Naringenin, a flavonoid, has beneficial effects preventing cellular aging, preserving the functionality of photoreceptors, slowing down loss. However, role potential mechanism naringenin aging mouse retina require further investigation. In this study, we evaluated on eye using electroretinogram (ERG) hematoxylin eosin staining explored its by western blotting....
Gastric cancer (GC), as an epidemic worldwide, has more than 1 million new cases and estimated 769,000 deaths worldwide in 2020, ranking fifth fourth global morbidity mortality. In mammals, both miRNAs transcription factors (TFs) play a partial role gene expression regulation. The mRNA profile miRNA of GEO database were screened by GEO2R for differentially expressed genes (DEGs) (DEMs). Then, DAVID annotated the functions DEGs to understand played biological processes. prediction potential...
Not all eligible breast cancer (BC) patients could afford the expensive test of 21-gene recurrence score (RS) assay. This study aimed to identify clinicopathological factors associated with high-risk RS and examine whether these correlate benefit chemotherapy.
Excessive bone resorption by osteoclasts contributes significantly to osteoclast-related diseases such as periprosthetic osteolysis and osteoporosis. Osteolysis in a titanium particle-induced calvarial model loss an ovariectomized mice occurred similarly those humans; thus, these models can be used evaluate potential therapies for aseptic prosthetic loosening Celastrol, which is extracted from the seeds of genus Tripterygium, has been thoroughly investigated its anti-inflammatory anti-cancer...
Abstract Background Sjögren’s syndrome (SS) is an autoimmune disease with limited effective treatment options. This study aimed to explore the underlying mechanism by which genistein–estrogen receptor alpha (ERα) complex targets X-inactive specific transcript ( Xist ) then leads inhibition of ferroptosis regulating acyl-CoA synthetase long-chain family member 4 (ACSL4) expression in salivary gland epithelial cells (SGECs) attenuate SS. Methods The effects genistein on progression and SS were...
To investigate the expression and clinical significance of miR-152 CYFRA21-1 in ovarian cancer (OC) tissues. Seventy-four OC patients diagnosed our hospital from March 2016 to April 2019 (research group, RG) 30 with benign tumor at same time (control CG) were collected as research objects this experiment. qRT-PCR ELISA used detect observe levels patient tissues serum. ROC curves drawn analyze diagnostic value OC. The clinicopathological correlation analysis was observed, Pearson examine...