A5115010729- Renal cell carcinoma treatment
- Renal and related cancers
- Bladder and Urothelial Cancer Treatments
- Cancer, Hypoxia, and Metabolism
- Pediatric Urology and Nephrology Studies
- Ureteral procedures and complications
- Renal and Vascular Pathologies
- Kidney Stones and Urolithiasis Treatments
- Urological Disorders and Treatments
- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Cancer Genomics and Diagnostics
- MRI in cancer diagnosis
- Chronic Kidney Disease and Diabetes
- Sarcoma Diagnosis and Treatment
- Acute Kidney Injury Research
- Prostate Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Urinary and Genital Oncology Studies
- Multiple and Secondary Primary Cancers
- Prostate Cancer Treatment and Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Research and Treatments
- Chromatin Remodeling and Cancer
- Multiple Myeloma Research and Treatments
Renji Hospital
2016-2025
Nanjing University
2015-2025
Nanjing General Hospital of Nanjing Military Command
2015-2025
Shanghai Jiao Tong University
2016-2025
Nanjing Medical University
2019-2025
State Grid Corporation of China (China)
2024
Guizhou University
2024
Beijing Hospital
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2003-2023
Chinese PLA General Hospital
2023
Objective To compare outcomes of ureteric and renal stone treatment with ureteroscopy (URS) in patients or without the placement a preoperative JJ stent. Patients Methods The Clinical Research Office Endourological Society (CROES) URS Global Study collected prospective data for 1 year on consecutive stones treated at 114 centres around world. that had stent were compared those did not. Inverse‐probability‐weighted regression adjustment (IPWRA) was used to examine effect stone‐free rate...
Abstract Background Our previously published reports have described an effective biocontrol agent named Pseudomonas sp. M18 as its 16S rDNA sequence and several regulator genes share homologous sequences with those of P. aeruginosa , but there are unusual phenotypic features. This study aims to explore strain specific genomic features gene expression patterns at different temperatures. Results The complete genome is composed a single chromosome 6,327,754 base pairs containing 5684 open...
Xp11 renal cell carcinoma (RCC) with different gene fusions may have clinicopathologic features. We sought to identify variant in TFEB translocation RCC. A total of 31 cases RCCs were selected for the current study; MALAT1-TFEB fusion was identified 25 (81%, 25/31) using probes. The remaining 6 (19%, 6/31) further analyzed by RNA sequencing and 5 them detected TFEB-associated fusions, including 2 ACTB-TFEB, 1 EWSR1-TFEB, CLTC-TFEB, potential PPP1R10-TFEB (a paracentric inversion gene,...
Objective To evaluate whether remote ischaemic preconditioning ( RIPC ) reduces renal injury in patients undergoing laparoscopic partial nephrectomy LPN ). Patients and methods In all, 82 were randomly assigned to either the or control group, with 40 38 patients, respectively completing 6‐months follow‐up. was conducted after induction of anaesthesia, which consisted three 5‐min cycles right lower limb ischaemia 5 min reperfusion during each cycle. The primary outcome absolute change...
The rhizobacterium Pseudomonas aeruginosa M18 can produce a broad spectrum of secondary metabolites, including the antibiotics pyoluteorin (Plt) and phenazine-1-carboxylic acid (PCA), hydrogen cyanide, siderophores pyoverdine pyochelin. antibiotic biosynthesis is coordinately controlled by multiple distinct regulatory pathways, which GacS/GacA system activates Plt but strongly downregulates PCA biosynthesis. Here, we investigated global influence gacA mutation on transcriptome related...
We evaluated the functional outcome, safety and efficacy of zero ischemia laparoscopic radio frequency ablation assisted tumor enucleation compared with conventional partial nephrectomy.A prospective randomized controlled trial was conducted from April 2013 to March 2015 in patients cT1a renal scheduled for nephron sparing surgery. All were followed at least 12 months. Patients group underwent after without hilar clamping. The primary outcome change glomerular filtration rate affected kidney...
We investigated the diagnostic performance of urinary kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) for acute (AKI) in 90 obstructive nephropathy patients.Urine samples were obtained preoperatively 4, 8, 12, 24, 48 72 h postoperatively, KIM-1 NGAL contents measured by enzyme linked immunosorbent assay corrected against urine creatinine content. The receiver operating characteristic (ROC) curves used to determine area under curve (AUCs) AKI.The...
Thyroid-like follicular carcinoma of the kidney (TLFCK) is an extremely rare subtype renal cell with close resemblance to well-differentiated thyroid neoplasms. TLFCK has not been included in 2004 World Health Organization (WHO) classification due limited data available. Only 27 cases have reported literature date. Herein, we report a unique case that presented as striking skull and meningeal metastasis 5 years after initial diagnosis; this first such novel pattern. A 68-year-old woman was...
Abstract Epstein-Barr virus nuclear antigen 2 (EBNA2) is a transactivator of viral and cellular gene expression, which plays critical role in the virus-associated diseases. It was reported that EBNA2 regulates expression by reorganizing chromatin manipulating epigenetics. Recent studies showed liquid-liquid phase separation an essential epigenetic transcriptional regulation. Here we show reorganized topology to form accessible domains (ACDs) host genome separation. The N-terminal region...
534 Background: Pts with VHL disease are at risk of developing malignant tumors such as renal cell carcinoma (RCC) due to gene inactivation, leading activation hypoxia-inducible factors (HIFs). In the phase 2 LITESPARK-004 study, HIF-2α inhibitor belzutifan (MK-6482) demonstrated antitumor activity and a manageable safety profile in pts disease–associated tumors; however, study did not include from Asia. We present results for mainland China localized enrolled cohort B1 2, open-label,...
Targeted membrane protein degradation using cell surface E3 ligases RNF43/ZNRF3 via proteolysis targeting chimeras (PROTACs) represents an effective strategy for treating drug targets that cannot be fully inhibited traditional inhibitors. Several ingenious have been developed to tether target proteins, resulting in the of at sub‐nanomolar concentrations both vitro and vivo. However, currently available binders are genetically encoded poor plasticity, which limits design promotion such...
Targeted membrane protein degradation using cell surface E3 ligases RNF43/ZNRF3 via proteolysis targeting chimeras (PROTACs) represents an effective strategy for treating drug targets that cannot be fully inhibited traditional inhibitors. Several ingenious have been developed to tether target proteins, resulting in the of at sub‐nanomolar concentrations both vitro and vivo. However, currently available binders are genetically encoded poor plasticity, which limits design promotion such...