A5080643464- Prostate Cancer Treatment and Research
- Extracellular vesicles in disease
- Prostate Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Mass Spectrometry Techniques and Applications
- Immunotherapy and Immune Responses
- Cancer, Lipids, and Metabolism
- PARP inhibition in cancer therapy
- Ferroptosis and cancer prognosis
- Urinary Bladder and Prostate Research
- Parkinson's Disease Mechanisms and Treatments
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Nanoplatforms for cancer theranostics
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Nuclear Receptors and Signaling
- DNA Repair Mechanisms
- Urologic and reproductive health conditions
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Radiopharmaceutical Chemistry and Applications
- Hormonal and reproductive studies
- FOXO transcription factor regulation
- Microbial Inactivation Methods
Shanghai Jiao Tong University
2020-2025
Renji Hospital
2020-2025
Jiangmen Central Hospital
2023
Shanghai Children's Hospital
2022
Mianyang Central Hospital
2019
Qingdao University
2016-2017
Abstract Tumor‐associated macrophages (TAMs) play an essential role in tumor therapeutic resistance. Although the lethal effect of ferroptosis on cells is well reported, how TAMs inhibit tumors has not been clearly defined. In this study, it demonstrated that TAM‐secreted taurine suppresses prostate cancer (PCa) by activating Liver X receptor alpha/Stearoyl‐Coenzyme A desaturase 1 (LXRα/SCD1) pathway. Blocking intake via inhibition transporter TauT restores sensitivity to tumors....
High-throughput metabolic fingerprinting has been deemed one of the most promising strategies for addressing high false positive rate prostate cancer (PCa) diagnosis in prostate-specific antigen (PSA) gray zone. However, current remains challenging achieving high-precision metabolite detection complex biological samples (e.g., serum and urine). Herein, a novel self-assembly MoS
Great attention is paid to the role of androgen receptor (AR) as a central transcriptional factor in driving growth prostate cancer (PCa) epithelial cells. However, understanding PCa-infiltrated immune cells and impact deprivation therapy (ADT), first-line treatment for advanced PCa, on PCa microenvironment remains limited. On other hand, checkpoint blockade has revolutionized certain types, but fails achieve any benefit due an suppressive environment. In this study, it reported that AR...
Purpose: To identify extracellular vesicle (EV)-delivered microRNAs in the patient's serum as indicators for bone-metastatic prostate cancer. Methods: First, profiling change of EV-delivered miRNAs patients with either benign prostatic hyperplasia (BPH), non-bone metastatic cancer or was detected by microRNA deep sequencing assay and microRNA-chip array assay, respectively. Second, candidates were further confirmed using TaqMan two independent validation cohorts total 176 BPH, bone to seek...
Abstract Prostate cancer (PCa) is the second most common in males worldwide. The Gleason scoring system, which classifies pathological growth pattern of cancer, considered one important prognostic factors for PCa. Compared to indolent PCa, PCa with high score (h‐GS GS ≥ 8) has greater clinical significance due its aggressiveness and poor prognosis. It crucial establish a rapid, non‐invasive diagnostic modality decipher patients h‐GS as early possible. In this study, ferric...
No AccessJournal of UrologyAdult Urology1 Feb 2021Comparative Analysis Genomic Alterations across Castration Sensitive and Resistant Prostate Cancer via Circulating Tumor DNA Sequencing Liancheng Fan, Xiaochen Fei, Yinjie Zhu, Jiahua Pan, Jianjun Sha, Chenfei Chi, Yiming Gong, Xinxing Du, Lixin Zhou, Baijun Dong, Wei Xue FanLiancheng Fan Department Urology, Renji Hospital, School Medicine, Shanghai Jiao Tong University, Shanghai, China , FeiXiaochen Fei ZhuYinjie Zhu PanJiahua Pan ShaJianjun...
Prostate cancer (PCa) is one of the most common malignancies in men worldwide and has caused increasing clinical morbidity mortality, making timely diagnosis accurate staging crucial. The authors introduced a novel approach based on mass spectrometry for precise stratification PCa to facilitate decision-making.
Neuroendocrine prostate cancer (NEPC) is a lethal subset of which characterized by neuroendocrine differentiation and loss androgen receptor (AR) signaling. Growing evidence reveals that cell lineage plasticity crucial in the failure NEPC therapies. Although studies suggest involvement neural transcription factor PAX6 drug resistance, its specific role remains unclear. The expression was identified via bioinformatics immunohistochemistry. CCK8 assay, colony formation tumorsphere assay...
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the loss of dopaminergic (DA) neurons in substantia nigra (SN) and subsequent DA depletion striatum. Microglia activation nigral iron accumulation play important roles pathogenesis PD. Activated microglia show increased deposits. However, relationship between remains unclear. In present study, we aimed to determine how levels affect interleukin-6 (IL-6) synthesis, effect IL-6 on cellular metabolism BV2...
Abstract Prostate cancer is the most common in over 50% of countries and third malignancy worldwide. The tumor microenvironment includes non‐cancerous cells components present tumor, including molecules they produce release. proliferation, angiogenesis, metastasis, drug resistance are closely associated with microenvironment. With continuous development vitro models, have gradually become important tools for recapitulating vivo parental tumors studying reciprocal interactions between their...
No AccessJournal of UrologyAdult Urology1 Sep 2021Distinct Response to Platinum-Based Chemotherapy among Patients with Metastatic Castration-Resistant Prostate Cancer Harboring Alterations in Genes Involved Homologous Recombination Liancheng Fan, Xiaochen Fei, Yinjie Zhu, Chenfei Chi, Jiahua Pan, Jianjun Sha, Zhixiang Xin, Yiming Gong, Xinxing Du, Yanqing Wang, Baijun Dong, and Wei Xue FanLiancheng Fan Department Urology, Renji Hospital, School Medicine, Shanghai Jiao Tong University,...
The application of circulating tumor cells (CTCs) in both clinical practice and research has been continuously limited by the rare number targets that can be found a tube peripheral blood. Diagnostic leukapheresis (DLA) was used to increase sampling volume. AdnaTest process whole leukopak, RNAs captured CTCs then profiled NanoString nCounter platform. Spike-in experiments leukopaks from patients with metastatic prostate cancer were validate this new strategy. leukopak further concentrated...
Neuroendocrine prostate cancer (NEPC), a lethal subset of (PCa), is characterized by loss AR signaling and resistance to AR-targeted therapy. While it well reported that second-generation blockers induce neuroendocrine (NE) trans-differentiation castration-resistant (CRPC) promote the occurrence NEPC, pluripotent transcription factors might be potential regulators, underlying molecular mechanisms remain unclear.