A5078050158- RNA modifications and cancer
- Toxin Mechanisms and Immunotoxins
- Natural product bioactivities and synthesis
- Plant Molecular Biology Research
- Bladder and Urothelial Cancer Treatments
- Cancer-related gene regulation
- Viral-associated cancers and disorders
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- RNA regulation and disease
- Fungal Plant Pathogen Control
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
Southern Medical University
2019-2024
Abstract Epstein-Barr virus nuclear antigen 2 (EBNA2) is a transactivator of viral and cellular gene expression, which plays critical role in the virus-associated diseases. It was reported that EBNA2 regulates expression by reorganizing chromatin manipulating epigenetics. Recent studies showed liquid-liquid phase separation an essential epigenetic transcriptional regulation. Here we show reorganized topology to form accessible domains (ACDs) host genome separation. The N-terminal region...
Casticin, an isoflavone compound extracted from the herb Fructus Viticis, has demonstrated anti-inflammatory and anticancer activities properties. The aim of this study was to investigate effects mechanisms casticin in nasopharyngeal carcinoma (NPC) cells determine its potential for targeted use as a medicine.NPC were used perform experiments. CCK‑8 assay colony formation assays assess cell viability. Flow cytometry measure cycle apoptosis analysis (annexin V/PI assay). A three-dimensional...
Here, we establish a single-nucleotide resolution method to identify 8-oxoguanine in RNA based on its ability hinder ligation.
A tumor suppressor protein, stromal antigen 2 (STAG2), has recurrent mutations or loss of expression in many tumors including bladder cancer, osteosarcoma (OS), and leukemia. However, the mechanism STAG2 promoting tumorigenesis is still unclear.The distribution cancer was determined through COSMIC database; we also generated a truncating mutation OS cell line U2OS cells to mimic common OS. CCK-8 assay employed evaluate effect on proliferation chemo-resistance cells. Cell apoptosis cycle...