A5100405793- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Spine and Intervertebral Disc Pathology
- Orthopaedic implants and arthroplasty
- Musculoskeletal pain and rehabilitation
- Natural product bioactivities and synthesis
- Cancer-related gene regulation
- Foot and Ankle Surgery
- Kruppel-like factors research
- Gut microbiota and health
- Neuroendocrine regulation and behavior
- Renal Diseases and Glomerulopathies
- Plant Toxicity and Pharmacological Properties
- Synthesis of Organic Compounds
- Cancer-related molecular mechanisms research
- Tendon Structure and Treatment
- Tryptophan and brain disorders
- Healthcare and Venom Research
- Stress Responses and Cortisol
- Traditional Chinese Medicine Analysis
- Sphingolipid Metabolism and Signaling
- Plant Molecular Biology Research
- Cell death mechanisms and regulation
- Pediatric Urology and Nephrology Studies
- Diet and metabolism studies
Wangjing Hospital of China Academy of Chinese Medical Sciences
2012-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2024
Zhejiang Cancer Hospital
2019
Chongqing Medical University
2015
Alzheimer's disease (AD) is a progressive neurodegenerative characterized by memory loss, cognitive disorder, language dysfunction, and mental disability. The main neuropathological changes in AD mainly include amyloid plaque deposition, neurofibrillary tangles, synapse neuron reduction. However, the current anti-AD drugs do not demonstrate favorable effect altering pathological course of AD. Moreover, long-term use these usually accompanied with various side effects. Ginsenosides are major...
Epigenetic modifications are closely related to oncogene activation and tumor suppressor gene inactivation. The aim of this study was determine the effects ginsenoside Rg3 on epigenetic modification in ovarian cancer cells. Cell proliferation, metastasis, invasion apoptosis were respectively determined using Counting Kit‑8 (CCK‑8), wound healing, Transwell flow cytometric assays. Methylation levels methylation specific PCR (MSP). Related‑factor expression detected by conducting...
Ginsenoside Rg3 is one of the main constituents isolated from Panax ginseng, and exhibits cytotoxic effects against cancer cells. The present study aimed to investigate ginsenoside on human multiple myeloma cells, determine underlying molecular mechanisms. cells were exposed at various concentrations (0‑80 µM) for 48 h. A subsequent cell proliferation assay demonstrated that treatment with resulted in a dose‑dependent inhibition U266 RPMI8226 Furthermore, exposure led marked increase rate...
Total ginsenosides (TG), the major active constituents of ginseng, have been proven to be beneficial in treatment Alzheimer's disease (AD). However, underlying mechanism TG remains unclear. APP/PS1 mice and N2a/APP695 cells were used as vivo vitro model, respectively. Morris water maze (MWM) was investigate behavioral changes mice; neuronal pathological assessed by hematoxylin eosin (H&E) nissl staining; immunofluorescence staining examine amyloid beta (Aβ) deposition; Western blotting...
The development of mechanically active culture systems helps in understanding the role mechanical stress intervertebral disc (IVD) degeneration. Motion segment cultures facilitate application and control loads. purpose this study was to establish a culturing method for rabbit IVD motion segments observe effect static load on whole organ. Segments were cultured custom-made apparatuses under constant, compressive (3 kg) 2 weeks. Tissue integrity, matrix synthesis, gene expression profile...
Immunofluorescence of frozen tissue sections (IF-F) is a classic technique for renal immunopathologic examination. However, it has certain disadvantages, such as diffuse antigen distribution and few or even no glomeruli in the section. We developed new immunofluorescence staining using dual microwave retrieval paraffin-embedded (IF-DMP) compared IF-DMP with IF-F 406 biopsy samples. detected significantly more than did (P< .001). There was significant difference specificity sensitivity...
Ginseng, a traditional Chinese medicine, was used to prevent and treat many diseases such as diabetes, inflammation, cancer. In recent years, there are some reports about the treatment of lung adenocarcinoma with ginseng monomer compounds, but is no systematic study on related core targets mechanism in up now. Therefore, this systematically comprehensively studied molecular based network pharmacology further proved potential by A549 cell experiments for first time.The disease drug were...
Background: The development of mechanically active culture systems helps increase the understanding role mechanical stress in intervertebral disc (IVD) degeneration. Motion segment cultures allow for preservation native IVD structure, and adjacent vertebral bodies facilitate application control loads. purpose this study was to establish loading organ methods rabbit motion segments effect static load on whole organ. Methods: were harvested from lumbar spines cultured no-loading 6-well plates...
Functional dyspepsia (FD) is a non‑organic gastrointestinal disorder that has marked negative impact on quality of life. Compared with conventional pharmacological therapies, the traditional Chinese medicine weikangning (WKN) safe and effective treatment for FD. The present study aimed to determine molecular mechanisms underlying efficacy WKN. effect different concentrations WKN proliferation human gastric mucosal epithelial cell line GES‑1 was assessed. optimal concentration promote...
Bioinformatics analyses have shown that transmembrane and coiled-coil domain 1 (TMCO1) may be associated with lung adenocarcinoma. However, to the best of our knowledge, no current research has determined whether TMCO1 is involved in development The present study aimed identify association between demonstrated positive immunohistochemical staining adenocarcinoma tissues was significantly higher compared paracarcinoma tissues. Additionally, knockdown downregulate B-cell lymphoma-2 protein...
1H NMR-based metabolic profiling combined with multivariate data analysis was used to explore the phenotype of functional dyspepsia (FD) in stressed rats and evaluate intervention effects Chinese medicine Weikangning (WKN). After a 7-day period model establishment, 14-day drug administration schedule conducted WKN-treated group rats, normal control groups serving as negative controls. Based on NMR spectra urine serum from PCA, PLS-DA, OPLS-DA were performed identify changing profiles....
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To compare effect of serum Bushen Huoxue prescription on rabbit with intervertebral disc motion segments in vitro culture.Twenty-four New Zealand white rabbits aged from 4 to 6 months and weighted 2.5 3 kg were divided into medicated group control group, 7 each group. Rabbits excuted under condition asepsis, 28 spinal taken out loaded cultured culture apparatus. Nutrient solution contain 10% prescription, blank Seven discs between two groups observed by histomorphology, proteoglycan PAS/AB...