A5100781803- Nutrition and Health in Aging
- Frailty in Older Adults
- Blood Pressure and Hypertension Studies
- Cerebral Palsy and Movement Disorders
- Traditional Chinese Medicine Studies
- Folate and B Vitamins Research
- Body Composition Measurement Techniques
- Kawasaki Disease and Coronary Complications
- Statistical Methods in Epidemiology
- Acupuncture Treatment Research Studies
- Nanocluster Synthesis and Applications
- Balance, Gait, and Falls Prevention
- Vascular Malformations Diagnosis and Treatment
- Civil and Geotechnical Engineering Research
- Advanced Nanomaterials in Catalysis
- Medical Research and Treatments
- Intergenerational Family Dynamics and Caregiving
- Sepsis Diagnosis and Treatment
- Kidney Stones and Urolithiasis Treatments
- Gold and Silver Nanoparticles Synthesis and Applications
- Luminescence and Fluorescent Materials
- Nutritional Studies and Diet
- Organ and Tissue Transplantation Research
- Aquaculture disease management and microbiota
- Healthcare and Venom Research
Sichuan University
2012-2025
First Affiliated Hospital of Xinjiang Medical University
2025
Xinjiang Medical University
2025
Tsinghua University
2025
West China Second University Hospital of Sichuan University
2018-2025
Xinqiao Hospital
2025
Army Medical University
2025
Chengdu Research Base of Giant Panda Breeding
2024
Fujian Medical University
2022-2024
First Affiliated Hospital of Fujian Medical University
2022-2024
Neonatal acute respiratory distress syndrome (ARDS) has high morbidity and mortality rates worldwide, but there is a lack of pharmacologic treatment clinical targeted therapies. In this study, we aimed to explore the effects Lipocalin-2 (LCN2) on ferroptosis-mediated inflammation oxidative stress in neonatal ARDS potential mechanism. established an vivo mouse model vitro cell by LPS (Lipopolysaccharide) stimulation. Lung tissue injury was evaluated wet/dry ratios histopathological...
Abstract Cancer stem cells (CSCs) are crucial components of the tumor microenvironment that take part in initiation, progression, recurrence, metastasis, and resistance to chemotherapy. This study explores mechanisms through which CSCs maintain their stemness, especially tumors colorectal cancer (CRC), thus far remain uncertain. Our findings indicated expression miR‐20b‐5p is negatively correlated with metastasis‐associated lung adenocarcinoma transcript‐1 (MALAT1, r = −0.928, p 0.023) Oct4...
Objectives: To explore the role of renin–angiotensin–aldosterone system (RAAS) in pathogenesis pulmonary arterial hypertension (PAH) induced by chronic exposure to cigarette smoke. Methods: 48 healthy male SD rats were randomly divided into four groups (12/group): control group (group A); inhibitor alone B); induction C); + D). After establishment smoking-induced PAH rat model, right ventricular systolic pressure (RVSP) was detected using an inserted catheter; western blotting used detect...
Abstract Background Muscle mass and muscle quality assessed by computed tomography (CT) have been associated with poor prognosis in oncology surgery patients, but the relevant evidence was limited older patients. We hypothesized that indicators derived from opportunistic chest CT images at 12th thorax vertebra level (T12) could predict in‐hospital death, length of hospital stay (hospital LOS), costs among patients acute care wards. Methods conducted a prospective cohort study. Older admitted...
Blue emission fluorescent Au5 clusters with maximum quantum yield of 20.1% were synthesized by a simple photoreduction method using three specially designed tridentate polymer ligands. The evolution Au nanoclusters (Au NCs) under UV irradiation was studied fluorescence, UV-Vis and X-ray photoelectron spectroscopic techniques, suggesting that the fluorescence NCs is size-dependent associated presence Au(I) ions in NCs. effect structure on has also been discussed. These highly have potential...
Abstract Dysfunction of RNA-binding proteins, including TDP-43 and FUS, has been associated with amyotrophic lateral sclerosis (ALS); however, the underlying mechanisms are largely unknown. Here, we reported that a neuronal upregulation TRIM72 (Tripartite Motif Containing 72) in FUS mutation knockin ALS models slows disease progression. interacts Commander, protein complex for recycling membrane facilitating repair antioxidation. Exosomal is detected patient cerebrospinal fluid (CSF)...
Platinum-based chemotherapy is an important therapeutic approach for patients with advanced non-small cell lung cancer (NSCLC) without driver gene mutations. DNA damage and repair (DDR) can mitigate platinum-induced induce resistance to platinum agents. The status of DDR in wild-type NSCLC their role determining response prognosis platinum-based need be investigated. This study used next-generation sequencing (NGS) detect the mutation 47 genes seven signaling pathways investigate association...
A multifunctional polymer ligand, containing thiol, thioether, and ester functional groups, is designed used to prepare intense blue fluorescent gold nanoclusters (AuNCs) with a diameter of ∼1.2 nm high quantum yield (QY) 24.3% in organic media without using additional phase-transfer reagents. The size QY AuNCs can be fairly controlled by adjusting the molecular weight (Mn) concentration ligand. retain their fluorescence various solvents are stable for several months. same also silver...
Incretin-based therapies, including glucagon-like peptide 1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase-4 (DPP-4) inhibitors, are essential treatments in diabetes management due to their efficacy glycemic control the additional benefits of GLP-1 RAs, which include cardiovascular renal protection. However, concerns about potential associations with biliary disorders necessitate ongoing pharmacovigilance. This study analyzes link between these drugs adverse events (AEs) using FDA...
Background: Kawasaki disease (KD) is an acute systemic vasculitis with coronary artery lesions (CALs) being the major concern. Syndecan-1 (SDC-1) a core protein expressed on glycocalyx of endothelial cells. Shed SDC-1 in serum regarded as biomarker for activation or damage. Methods: In this study, we aimed to determine levels and evaluate relationship between CALs phase KD. Serum were measured 119 children KD 43 healthy normal controls 40 febrile disease. All patients administrated single...
Previous studies have shown an independent association between increased red cell distribution width (RDW) and mortality after acute myocardial infarction (AMI). However, evidence regarding the predictive significance of repeated measures RDW in patients with AMI remains scarce. We aimed to investigate dynamic profile in-hospital AMI.This was a cross-sectional study. extracted clinical data from Medical Information Mart for Intensive Care IIIV1.4 database. Demographic data, vital signs,...
BACKGROUND This study aimed to investigate the mechanism of CHEK2 gene dysfunction in drug resistance triple negative breast cancer (TNBC) cells. MATERIAL AND METHODS To perform our study, a stable wild type (CHEK2 WT) or Y390C mutation Y390C) expressed MDA-MB-231 cell line was established. MTT assay, apoptosis assay and cycle were carried out analyze viability, apoptosis, respectively. Western blotting qRT-PCR applied for related protein expression detection. RESULTS We found that IC50...