A5071176196- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Stress Responses and Cortisol
- Esophageal and GI Pathology
- Gallbladder and Bile Duct Disorders
- Atrial Fibrillation Management and Outcomes
- Phagocytosis and Immune Regulation
- Cytokine Signaling Pathways and Interactions
- Adipose Tissue and Metabolism
- Cardiac Arrhythmias and Treatments
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Hormonal Regulation and Hypertension
- Colorectal Cancer Screening and Detection
- Electrolyte and hormonal disorders
- Hematological disorders and diagnostics
- Cardiovascular Function and Risk Factors
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Venous Thromboembolism Diagnosis and Management
- Diverticular Disease and Complications
- Epigenetics and DNA Methylation
Second Affiliated Hospital of Nanchang University
2015-2025
Nanchang University
2016-2025
First Affiliated Hospital of Xinjiang Medical University
2025
Xinjiang Medical University
2025
Shanghai Jiao Tong University
2015-2024
Shanghai First People's Hospital
2015-2024
Wuxi Taihu Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2024
Peking Union Medical College Hospital
2024
Nanjing Medical University
2011-2023
Abstract Background N6-methyladenosine (m6A) is the most abundant reversible methylation modification of eukaryotic mRNA, and it plays vital roles in tumourigenesis. This study aimed to explore role m6A demethylase ALKBH5 pancreatic cancer (PC). Methods The expression its clinicopathological impact were evaluated PC cohorts. effects on biological characteristics cells investigated basis gain-of-function loss-of-function analyses. Subcutaneous orthotopic models further uncovered tumour...
Induced pluripotent stem cells (iPSCs) have the potential to revolutionise cell therapy; however, it remains unclear whether iPSCs can be generated from human osteoarthritic chondrocytes (OCs) and subsequently induced differentiate into chondrocytes.In present study, we investigated differentiation of OCs using defined transcription factors explored possibility these OC-derived for chondrogenesis.Our study demonstrates that are indistinguishable embryonic (hESCs).To promote chondrogenic...
Abstract Background Previous studies have investigated the sustained aberrantly activated Interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) signaling pathway is crucial for pancreatic cancer growth metastasis. Suppressor cytokine (SOCS3), as a key negative feedback regulator this pathway, usually down-regulated in various cancers. In present study, we aim at exploring biological function underlying molecular regulation mechanisms SOCS3 cancer. Methods The...
Abstract Junctional adhesion molecule-C (JAM-C) plays a key role in the promotion of reverse transendothelial migration (rTEM) neutrophils, which contributes to dissemination systemic inflammation and secondary organ damage. During acute pancreatitis (AP), inflammatory responses lead distant damage typically result lung injury (ALI). Here, we investigated rTEM neutrophils AP-associated ALI molecular mechanisms by JAM-C regulates neutrophil this disorder. In study, were identified peripheral...
Background and Purpose Dopamine has multiple anti‐inflammatory effects, but its role molecular mechanism in acute pancreatitis (AP) are unclear. We investigated the of dopamine signalling inflammatory response AP. Experimental Approach Changes pancreatic dopaminergic system effects dopamine, antagonists agonists D 1 2 receptors were analysed wild‐type pancreas‐specific Drd2 −/− mice with AP (induced by caerulein LPS or L‐arginine) acinar cells without cholecystokinin (CCK) stimulation. The...
To explore the mechanism by which microRNA-155 (miR-155) regulates pathogenesis of experimental colitis.A luciferase assay was performed to confirm binding miR-155 SHIP-1 3'-UTR. MiR-155 mimics, negative controls and expression/knockdown vectors were established then utilized in gain- loss-of-function studies raw264.7 cells primary bone marrow-derived macrophages (BMDMs). Thereafter, dextran sulfate sodium (DSS)-induced colitis mouse model with or without antagomiR-155 treatment established,...
Evaluating the impact of digestive system diseases is vital for devising effective prevention strategies. However, comprehensive reports on burden in China are lacking. Our study aimed to provide an overview and trends from 1990 2019 its provinces.
The goal of this study was to summarize the clinical features hyperlipidemic acute pancreatitis (HLAP), and help clinicians understand characteristic presentations HLAP.From July 2009 June 2013, 1073 cases were retrospectively assessed. characteristics HLAP non-HLAP statistically analyzed.The etiologic ratio in rose from 13% 25.6% 2013. Diabetes mellitus, fatty liver, recurrence positively correlated with HLAP, female sex, age (>60 years), alkaline phosphatase level negatively HLAP....
Circadian disruption has been implicated in tumour development, but the underlying mechanism remains unclear. Here, we show that molecular clockwork within malignant human pancreatic epithelium is disrupted and this mediated by miR-135b-induced BMAL1 repression. miR-135b directly targets 3'-UTR thereby disturbs oscillator, downregulation of essential for realignment cellular clock. Asynchrony between expression impairs local circadian gating control suppression significantly promotes...
Background and Purpose Macrophage infiltration activation is a critical step during acute pancreatitis (AP). We have shown that pancreas‐specific D 2 receptor signalling protects against AP severity. As it unclear to what extent myeloid‐specific mediates AP, we investigated the role of in AP. Experimental Approach Using wild‐type LysM +/cre fl/fl mice, was induced by l ‐arginine, caerulein LPS. Murine bone marrow‐derived macrophages human peripheral blood mononuclear cells (PBMCs) were...
Acinar cell death and inflammatory response are two important events which determine the severity of acute pancreatitis (AP). Endoplasmic reticulum (ER) stress necroptosis involved in this process, but relationships between them remain unknown. Here, we analyzed interaction ER underlying mechanisms during AP. Experimental was induced Balb/C mice by caerulein (Cae) lipopolysaccharide (LPS) or L-arginine (L-Arg) vivo , pancreatic acinar cells were also used to follow cellular cholecystokinin...
Increasing reports suggest that discovery of microRNAs (miRNAs) might provide a novel therapeutical target for human cancers, including osteosarcoma. Previous studies have shown miR-32 was dysregulated in breast and endometrial cancer. However, its biological roles osteosarcoma remain unclear. In the current study, we found significantly down-regulated tissues, compared with adjacent normal tissues. vitro further demonstrated mimics were able to suppress, while antisense oligos promoted cell...
Pancreatic fibrosis, a prominent feature of chronic pancreatitis (CP), induces persistent and permanent damage in the pancreas. stellate cells (PSCs) provide major source extracellular matrix (ECM) deposition during pancreatic injury, activation PSCs plays vital role progression fibrosis. Retinoic acid (RA), retinoid, has broad range biological functions, including regulation cell differentiation proliferation, attenuating progressive fibrosis multiple organs. In present study, we...
Abstract Pancreatic cancer ( PC ) is an aggressive malignancy associated with a poor prognosis and low responsiveness to chemotherapy radiotherapy. Most patients have metastatic disease at diagnosis, which partly accounts for the high mortality from this disease. Here, we explored role of transcription factor sex‐determining region Y‐box (Sox) 6 in invasiveness cells. We showed that Sox6 down‐regulated association overexpression suppressed cell proliferation migration vitro tumour growth...