A5072301682- Genetics, Aging, and Longevity in Model Organisms
- Endoplasmic Reticulum Stress and Disease
- Mitochondrial Function and Pathology
- Circadian rhythm and melatonin
- Gut microbiota and health
- HIV Research and Treatment
- Estrogen and related hormone effects
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- Functional Brain Connectivity Studies
- Hormonal Regulation and Hypertension
- Autophagy in Disease and Therapy
- Wnt/β-catenin signaling in development and cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Endometriosis Research and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Neuroendocrine regulation and behavior
- RNA regulation and disease
- CRISPR and Genetic Engineering
- Diabetes and associated disorders
- RNA modifications and cancer
- Signaling Pathways in Disease
Second Affiliated Hospital of Xi'an Jiaotong University
2014-2025
University of California, San Francisco
2019-2025
UConn Health
2023-2025
Chinese Academy of Sciences
2007-2025
Institute for Neurodegenerative Disorders
2019-2025
Affiliated Hospital of Jining Medical University
2025
Ningbo University Affiliated Hospital
2025
Institute of Solid State Physics
2025
Shaanxi Blood Center
2024
Jiaxing University
2024
<h3>Objective</h3> This study used resting-state functional MRI (fMRI) to evaluate regional and network alterations in patients with Parkinson9s disease (PD) without depression. <h3>Method</h3> We recruited 29 PD depression (PD-Dep), 30 (PD-NDep), normal controls. All participants underwent fMRI scans on a 3-T MR system. The amplitude of low-frequency fluctuation (ALFF) blood oxygen level-dependent signals was characterise cerebral function. Functional integration the brain evaluated by...
Investigating the molecular mechanisms of myocardial infarction (MI) and subsequent heart failure have gained considerable attention worldwide. Long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been previously demonstrated to regulate proliferation metastasis several tumors. However, little is known about effects MALAT1 in MI regulating cell date after MI. In our study, first, it was shown that expression levels were increased samples compared...
Cardiac hypertrophy is closely correlated with diverse cardiovascular diseases, augmenting the risk of heart failure and sudden death. Long non-coding RNAs (lncRNAs) have been studied in cardiac for their regulatory function. LncRNA MEG3 has reported human cancers. Whereas, it unknown whether regulates growth hypertrophy. Therefore, this study aims to investigate specific role progression Here, we found that contributed pathogenesis expression was remarkably strengthened mice which undergone...
The unfolded protein response (UPR) detects and restores deficits in the endoplasmic reticulum (ER) folding capacity. Ceapins specifically inhibit UPR sensor ATF6α, an ER-tethered transcription factor, by retaining it at ER through unknown mechanism. Our genome-wide CRISPR interference (CRISPRi) screen reveals that function is completely dependent on ABCD3 peroxisomal transporter. Proteomics studies establish physically associates with ER-resident ATF6α cells vitro a Ceapin-dependent manner....
In the eukaryotic cytosol, Hsp70 and Hsp90 chaperone machines work in tandem with maturation of a diverse array client proteins. The transfer nonnative clients between these systems is essential to chaperoning process, but how it regulated still not clear. We discovered that NudC an factor unprecedented mode action: interacts Hsp40 Hsp40-Hsp70-client complexes displaces Hsp70. Then, interaction allows direct Hsp40-bound for further processing. Consistent this mechanism, increases activation...
Although diet affects growth and behaviour, the adaptive mechanisms that coordinate these processes in non-optimal food sources are unclear. Here we show C. elegans tmc-1 channel, which is homologous to mammalian tmc deafness genes, attenuates development inhibits sexual behaviour food, synthetic CeMM medium. In medium, signalling from pharyngeal MC neurons body wall muscles slows larval development. However, non-standard diet, mutation accelerates development, by impairing excitability of...
Background A large number of new causative and risk genes for amyotrophic lateral sclerosis (ALS) have been identified mostly in patients European ancestry. In contrast, we know relatively little regarding the genetics ALS other ethnic populations. This study aims to provide a comprehensive analysis an unprecedented cohort Chinese mainland population correlate with clinical features rare variants carriers. Methods total 1587 patients, including 64 familial (FALS) 1523 sporadic (SALS), 1866...
Abstract HBV covalently closed circular DNA (cccDNA) is drug-resistant and responsible for viral persistence. To facilitate the development of anti-cccDNA drugs, we developed a minicircle vector (MC)-based technology to produce large quantity recombined cccDNA (rcccDNA) resembling closely its wild-type counterpart both in structure function. The rcccDNA differed (wtcccDNA) only that it carried an extra 36-bp recombinant product attR upstream preC/C gene. Using procedure similar standard...
Abstract Background The gut is an important site for human immunodeficiency virus (HIV) infection and immune responses. role of mucosal cells in restoration patients infected with HIV undergoing antiretroviral therapy remains unclear. Methods Ileocytes, including 54 475 cells, were obtained from colonoscopic biopsies five HIV‐negative controls, nine immunological responders (IRs), three non‐responders (INRs) analyzed using single‐cell RNA sequencing. Immunohistochemical assays performed...
Pulmonary arterial hypertension (PAH) is often characterized by cell proliferation and migration of pulmonary smooth muscle cells (PASMCs). LncRNA cancer susceptibility candidate 2 (CASC2) has been revealed to be involved in PASMC injury hypoxia-induced hypertension. However, the exact molecular mechanisms whereby CASC2 regulates are still incompletely understood.The expression levels CASC2, miR-222 inhibitor growth 5 (ING5) were measured using quantitative real-time polymerase chain...