A5100387664- Intracerebral and Subarachnoid Hemorrhage Research
- Parkinson's Disease Mechanisms and Treatments
- Neurofibromatosis and Schwannoma Cases
- Acute Ischemic Stroke Management
- Peripheral Neuropathies and Disorders
- Botulinum Toxin and Related Neurological Disorders
- Neuroblastoma Research and Treatments
- Neurological diseases and metabolism
- Pain Mechanisms and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Takotsubo Cardiomyopathy and Associated Phenomena
- Long-Term Effects of COVID-19
- Cerebral Venous Sinus Thrombosis
- Autoimmune Neurological Disorders and Treatments
- Acupuncture Treatment Research Studies
- Autophagy in Disease and Therapy
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Alzheimer's disease research and treatments
- Soft tissue tumor case studies
- Amyotrophic Lateral Sclerosis Research
- Signaling Pathways in Disease
- Moyamoya disease diagnosis and treatment
- Vascular Malformations Diagnosis and Treatment
- Biofield Effects and Biophysics
- Neurogenetic and Muscular Disorders Research
University of Alabama at Birmingham
2021-2025
Hertie Institute for Clinical Brain Research
2021-2022
University of Tübingen
2022
German Center for Neurodegenerative Diseases
2022
North Sichuan Medical University
2022
First Affiliated Hospital of Xi'an Jiaotong University
2021-2022
Peking University Shougang Hospital
2021
Henan Provincial Eye Hospital
2021
Henan Provincial People's Hospital
2021
Dongfeng General Hospital
2021
The protein α-synuclein (α-Syn) has a central role in the pathogenesis of Parkinson's disease (PD) and immunotherapeutic approaches targeting this molecule have shown promising results. In study, novel antibodies were generated against specific peptides from full length human α-Syn evaluated for effectiveness ameliorating α-Syn-induced cell death behavioral deficits an AAV-α-Syn expressing rat model PD. Fisher 344 rats injected with rAAV vector into right substantia nigra (SN), while control...
Background A large number of new causative and risk genes for amyotrophic lateral sclerosis (ALS) have been identified mostly in patients European ancestry. In contrast, we know relatively little regarding the genetics ALS other ethnic populations. This study aims to provide a comprehensive analysis an unprecedented cohort Chinese mainland population correlate with clinical features rare variants carriers. Methods total 1587 patients, including 64 familial (FALS) 1523 sporadic (SALS), 1866...
Polygenic Risk Scores (PRS), which allow assessing an individuals' genetic risk for a complex disease, are calculated as the weighted number of alleles in individual's genome, with and their weights typically derived from results genome-wide association studies (GWAS). Among wide range applications, PRS can be used to identify at-risk individuals select them further clinical follow-up. Pathway scores based on single nucleotide polymorphisms (SNPs) assigned genes involved major disease...
In efforts to evaluate potential biomarkers and drug targets for Neurofibromatosis Type I (NF1) we utilized affinity mass spectrometry global proteomics investigate how variation within loss of NF1 affect immortalized human Schwann cells. We used Strep tagged mNf1 cDNAs (both wild type (WT) variant) purity Protein-Protein interactors (PPIs) from the were able identify 98 PPIs show that some these bind differentially variant proteins. Next, evaluated proteomes. identified over 1900 proteins...
The pathological process of Parkinson's disease (PD) is closely associated with the death nigral neurons, for which an effective treatment has yet to be found. Lithium, one most widely certified anticonvulsant and mood‑stabilizing agents, exhibits evident neuroprotective effects in epilepsy bipolar disorder. In present study, mechanisms by lithium acts on a chronic 1‑methyl‑4‑phenyl‑1,2,3,6‑tetrahydropyridine (MPTP) mouse model PD were investigated employing animal behavioral tests,...
We have created a panel of 29 NF1 variant complementary DNAs (cDNAs) representing missense variants, many with clinically relevant phenotypes, in-frame deletions, splice and nonsense variants. determined the functional consequences assessing their ability to produce mature neurofibromin restore Ras signaling activity in null (-/-) cells. cDNAs demonstrate variant-specific differences protein levels, suggesting that some variants lead neurofibromatosis type 1 (NF1) gene or instability...
Abstract Objective Cerebral microbleeds (CMBs) is a subtype of cerebral small vessel disease. Their underlying pathogenesis remains unclear. The aim this study was to investigate the association between infectious burden (IB) and CMBs. Methods Seven hundred seventy‐three consecutive patients who were hospitalized in Department Neurology General Hospital Western Theater Command without severe neurological symptoms recruited selected pilot cross‐sectional study. CMBs assessed using...
Introduction COVID-19 is a public health emergency of international concern, which characterised by rapid and widespread transmission, high mortality complications. Several studies have shown the benefits tai chi qigong for recovery after COVID-19; however, no meta-analysis has been reported. Therefore, purpose this study to evaluate efficacy safety and/or on rehabilitation through systematic review provide reference basis clinical application. Methods analysis This will use Cochrane...
This study aimed to evaluate the demographic and clinical characteristics, treatments outcomes of concomitant acute myocardial infarction (AMI) intracranial hemorrhage (ICH). All patients diagnosed with AMI ICH admitted our institution were included retrospectively. The patient demographics, neuroimaging treatment approaches analyzed, interest disability as defined by modified Rankin Scale (mRS) score all-cause mortality within 1 year follow-up. Of a total 4972 AMI, 8 (0.2%) recruited for...
Background: Guillain-Barré syndrome (GBS) is an acute immune-mediated disorder in the peripheral nervous system (PNS) characterized by symmetrical limb weakness, sensory disturbances, and clinically absent or decreased reflexes. Pantalgia dysautonomia, including cardiovascular abnormalities, are common findings spectrum of GBS. It usually challenging to distinguish GBS-related electrocardiogram (ECG) abnormities chest pain from coronary (ACS) patients with GBS due similar clinical symptom...
The aim of this study was to analyze the effect tirofiban on new cerebral microhemorrhage after mechanical thrombectomy in patients with acute ischemic stroke.In total, 203 stroke treated by our department neurology were enrolled as research objects. divided into two groups: who used within 24 h surgery assigned group (78 subjects), while did not use conventional (125 subjects). Magnetic resonance imaging detect new-onset microbleeds surgery. National Institute Health Stroke Scale, modified...
Objective To explore the therapeutic efficacy, safety and complication incidence of microsurgical craniectomy for hypertensive intracerebral hemorrhage. Methods 105 patients with hemorrhage (the bleeding volume was 30-80 mL) were randomly divided into medical treatment (n=50) (n=55). Outcomes evaluated including patients' neurological functional deficiency scores 21 d after treatment, curative effect, mortality within 6 months. Results The in surgical group significantly superior to those...
Objective To investigate the predictive value of thromboelastography (TEG) parameters for hematoma enlargement after intracerebral hemorrhage. Methods Patients with primary hemorrhage within 6 h onset admitted to Second People's Hospital Changshu between March 2016 and 2018 were enrolled prospectively. Hematoma was defined as volume detected by CT 48 increased >12.5 cm3 or >33% compared that at admission. The baseline data in group non-hematoma compared. Multiple logistic regression...
Abstract Background MCA has several anomalies, such as accessory MCA, duplicated and twig-like up to now all these reported anomalies were hypothesized due the failure in fusion of primitive arterial network. No anomaly over fused been reported. Case presentation A 59- year- old male was hospitalized with a history paroxysmal slurred speech left side headache for week, his blood pressure 160/80 mmHg he manifested mild incomplete motor aphasia at time admission. The head neck CTA DSA...
Abstract We investigated the feasibility of utilizing an exon skipping approach as a genotype-dependent therapeutic for neurofibromatosis type 1 (NF1) by determining which NF1 exons might be skipped while maintaining neurofibromin function. Human is well-known GTPase activating protein (GAP), but outside its GAP-related domain (GRD), it unclear how critical other regions are Initial in silico analysis predicted that can with minimal loss Utilizing novel Nf1 cDNA system, we performed...
Abstract Background To detect the superficial and buried optic disc drusen (ODD) with swept-source optical coherence tomography (SS-OCT). Methods Retrospective cross-sectional study.Twenty patients (age 18-74 years) diagnosed ODD via B-scan ultrasonography were analysed. All underwent color fundus photography (CFP), ultrasonography, autofluorescence (FAF), SS-OCT.We defined each hyporeflective signal mass of SS-OCT as an ODD, recorded its location relationship Bruch’s membrane opening (BMO),...