A5100414468- Nutrition and Health in Aging
- Frailty in Older Adults
- Inflammatory mediators and NSAID effects
- Dysphagia Assessment and Management
- Body Composition Measurement Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Tracheal and airway disorders
- Chinese history and philosophy
- Conducting polymers and applications
- Organic Electronics and Photovoltaics
- Dementia and Cognitive Impairment Research
- Voice and Speech Disorders
- Cardiac electrophysiology and arrhythmias
- Sirtuins and Resveratrol in Medicine
- Healthcare and Venom Research
- Synthesis of Organic Compounds
- Cholinesterase and Neurodegenerative Diseases
- Intensive Care Unit Cognitive Disorders
- Ion channel regulation and function
- Lung Cancer Treatments and Mutations
- Alzheimer's disease research and treatments
- Electrospun Nanofibers in Biomedical Applications
- Bioactive natural compounds
- Hospitality and Tourism Education
- NF-κB Signaling Pathways
Capital Medical University
2021-2025
Beijing Hospital of Traditional Chinese Medicine
2025
ShenZhen People’s Hospital
2025
Jiangsu Hengrui Medicine (China)
2025
Sichuan University
2015-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2024
First People's Hospital of Chongqing
2024
Fujian Medical University
2024
Shandong Provincial Hospital
2024
First Affiliated Hospital of Fujian Medical University
2024
Abstract Two wide bandgap star‐shaped small molecular acceptors, para‐TrBRCN and meta‐TrBRCN , are synthesized for efficient nonfullerene polymer solar cells (PSCs). The tiny structural variation by just changing the linkage positions affects largely inherent properties of resulting molecules. Both molecules have a nonplanar 3D structure, which can prevent excessively aggregation to realize optimized morphology ideal domain size in their active blends. Compared exhibits smaller distortions...
Lung cancer patients co-harboring EGFR Ex19del mutation and MET de novo amplification is extremely uncommon. Thus, the optimal therapeutic strategies, treatment-related complications, prognosis for such remain unclear. Herein, we describe a case of patient who presented targeted (almonertinib)-induced interstitial lung disease (ILD). We propose that with may benefit more from dual-targeted therapy than pemetrexed carboplatin chemotherapy along bevacizumab. However, increase risk ILD, so it...
Biocompatible poly(propylene carbonate) (PPC)/polycaprolactone (PCL) shape memory blends were fabricated using melt blending. The performance of these was found to depend remarkably on their components. On addition 25 vol % PCL, one blend (PL-25) achieved an optimal shape-fixing ratio (Rf) and -recovery (Rr). Specifically, its Rr considerably increased by 24.1 50.0% compared with those pure PPC respectively, because the restricted irreversible deformation amorphous chains cross-linked tiny...
Objectives: We investigated whether there was a higher prevalence of cognitive impairment (CI) and/or physical frailty (PF) in persons with diabetes compared to their non-diabetic counterparts, and the individual combined impact CI PF on functional mortality outcomes among diabetic older persons.Method: Community-living participants (N = 2696) aged 55 above were assessed (MMSE) (CHS criteria) status. Among 486 persons, we estimated odds ratio 95% confidence intervals (OR, CI) association...
With increasing life expectancy in China, the associated burden of low back and neck pain (spinal pain) on healthcare system increases, posing a substantial public health challenge. This study aimed to investigate trends spinal incidence across China from 1990 2019 predict between 2020 2030.
A new small molecule using 2D benzodithiophene with fluorinated thiophene side chains as a central unit, D3RTBDTTF, is synthesized for highly efficient solar cells (SM-OSCs). The pristine D3RTBDTTF device shows an efficiency of 9.24%. further increased to 9.80% after solvent-vapor annealing process, which among the top values reported SM-OSCs. As service our authors and readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed may be...
SIRT2 is potently and selectively inhibited by <italic>in situ</italic>-generated KPM-2 (<bold>36</bold>)-ADP ribose conjugate.
Nicotinamide riboside kinase (NRK) plays an important role in the synthesis of β -nicotinamide nucleotide (NMN). NMN is a key intermediate NAD + synthesis, and it actually contribute to well-being our health. In this study, gene mining technology was used clone nicotinamide nucleoside fragments from S. cerevisiae , Sc NRK1 achieved high level soluble expression E. coli BL21. Then, reScNRK1 immobilized by metal affinity label optimize enzyme performance. The results showed that activity...
A 3-item SARC-F (termed SARC-F-3 in our study) was recently suggested as a screening tool for sarcopenia. The aim of this study to compare the diagnostic value community-dwelling older people. We conducted accuracy an urban community Chengdu, China. People aged 60 years or were included. Muscle mass, strength, and physical performance measured by bio-impedance analysis (BIA) device, handgrip gait speed test, respectively. Asia Working Group Sarcopenia (AWGS) criteria applied "gold...
The role of resveratrol (Res) in inflammation induced by ischemia/reperfusion is not well understood. aim the present study was to investigate whether Res modulates neutrophil accumulation and tumor necrosis factor‑α (TNF‑α) induction an ischemia/reperfusion‑injured rat heart model. rats were randomly exposed sham surgery, myocardial (MI/R) alone, MI/R + Res, L‑NG‑nitroarginine methyl ester (L‑NAME) methylene blue (MB). results demonstrated that compared with MI/R, reduced infarct area,...
Abstract Mucin 1 (MUC1) is a transmembrane glycoprotein with abundant glycosylation. In normal tissues, MUC1 present at the apical surface of epithelial cells, while epidermal growth factor receptor (EGFR) basal cells. Tumor cells lose apical-basal polarity, leading to even distribution EGFR and on cell surface, phenomenon that allows be spatially close together. And are highly co-expressed in variety tumors, e.g., non-small lung cancer (NSCLC), esophageal squamous carcinoma (ESCC) breast...
Introduction Kawasaki disease (KD) is an acute systemic vasculitis that primarily affects coronary arteries, and delayed diagnosis increases the risk of cardiovascular complications. Biomarkers are essential for improving diagnostic accuracy, especially in atypical cases. Gingival crevicular fluid (GCF), derived from periodontal tissues, contains serum components inflammatory mediators, has emerged as a valuable biofluid diagnosis. Previous studies suggest GCF protein profiles reflect immune...
The hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels, or cardiac ( I f )/neuronal h ) time- and voltage-dependent inward cation current are conventionally considered as monovalent-selective channels. Recently we discovered that calcium ions can permeate through HCN4 channels in neurons. This raises the possibility of Ca 2+ permeation , counterpart myocytes, because their structural homology. We performed simultaneous measurement fura-2 signals whole cell currents produced...