A5101974873- Soil Carbon and Nitrogen Dynamics
- MicroRNA in disease regulation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Soil and Unsaturated Flow
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Glycosylation and Glycoproteins Research
- Antibiotic Resistance in Bacteria
- Cancer Cells and Metastasis
- RNA Interference and Gene Delivery
- Pharmaceutical and Antibiotic Environmental Impacts
- RNA modifications and cancer
- Acupuncture Treatment Research Studies
- Lung Cancer Treatments and Mutations
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Traditional Chinese Medicine Analysis
- Irrigation Practices and Water Management
- Endoplasmic Reticulum Stress and Disease
- Carbohydrate Chemistry and Synthesis
- Neonatal Respiratory Health Research
- Flavonoids in Medical Research
- Bacterial biofilms and quorum sensing
- Medical Imaging and Pathology Studies
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
First Affiliated Hospital of Dalian Medical University
2012-2024
Dalian Medical University
2012-2024
University of South China
2024
Chaohu Hospital of Anhui Medical University
2024
Integrated Chinese Medicine (China)
2024
Pudong New Area People's Hospital
2022-2023
Chinese Academy of Agricultural Sciences
2011-2023
Institute of Environment and Sustainable Development in Agriculture
2018-2023
University of Shanghai for Science and Technology
2023
Fruit wastes are one of the main sources municipal waste. In order to explore potential fruit as natural resources bioactive compounds, antioxidant potency and total phenolic contents (TPC) lipophilic hydrophilic components in (peel seed) 50 fruits were systematically evaluated. The results showed that different residues had diverse variation was very large. Furthermore, compounds identified quantified, catechin, cyanidin 3-glucoside, epicatechin, galangin, gallic acid, homogentisic...
Chemoresistance remains the major obstacle to achieve optimal prognosis in gastric cancer patients, and underlying molecular mechanisms of cancer-associated fibroblasts (CAFs) chemoresistance remain poorly understood. We identified high pretherapeutical serum IL-8 level patients was associated with poor response platinum-based therapy, it increased gradually during neoadjuvant chemotherapy decreased after radical surgery. Immunohistochemistry assays showed that highly expressed tissues...
Pulmonary fibrosis (PF) can severely disrupt lung function, leading to fatal consequences. Salidroside is a principal active ingredient of Rhodiola rosea and has recently been reported protect against injures. The present study was aimed at exploring its therapeutic effects on PF. Lung fibrotic injuries were induced in SD rats by single intratracheal instillation 5 mg/kg bleomycin (BLM). Then, these administrated with 50, 100, or 200 salidroside for 28 days. BLM-triggered structure...
The differentiation of fibroblasts, which are promoted by transforming growth factor-β (TGF-β)/Smad, is involved in the process pulmonary fibrosis. Rho/Rho-associated coiled-coil-forming protein kinase (Rock) pathway may regulate fibroblast and myofibroblast expression α-smooth muscle actin (α-SMA), however, mechanism not clear. aim present study was to evaluate role Rho/Rock TGF-β/Smad TGF-β1-induced lung fibroblasts differentiation. Human embryonic were stimulated TGF-β1, Y-27632...
Liver cancer was the fourth leading cause of cancer-related death in 2015. Hepatocellular carcinoma (HCC) is most common type liver cancer. miR-1-3p plays important roles cancer, including prostate, bladder, lung and colorectal carcinoma. The function HCC remains poorly understood.qRT-PCR performed to detect expression cell lines (HCCLM3, Hep3B, Bel-7404, SMMC-7721) normal human hepatic line (LO2). HCCLM3 Bel-7404 cells were transfected with mimic or scramble control followed by...
Purpose: Lecithin/chitosan nanoparticles have shown great promise in the transdermal delivery of therapeutic agents. Baicalein, a natural bioactive flavonoid, possesses multiple biological activities against dermatosis. However, its topical application is limited due to inherently poor hydrophilicity and lipophilicity. In this study, baicalein-phospholipid complex was prepared enhance lipophilicity baicalein then lecithin/chitosan loaded with were developed improve retention permeability...
Sepsis-associated encephalopathy (SAE) is a severe and common complication of sepsis can induce cognitive dysfunction apoptosis neurons neuroinflammation. Emodin has been confirmed to have anti-inflammatory effects. Thus, we sought investigate the role in SAE.The cecal ligation puncture (CLP) method was used for establishment SAE mice model. For treatment Emodin, intraperitoneal injection 20 mg/kg performed before surgery. The Morris water maze open field tests were carried measurement...
Drip fertigation is an advanced technology combining micro-irrigation with fertilization, which conducive to deliver water and nutrients crops or fruit trees synchronously. To optimize drip scheduling for wine grape in North China, a three-year field experiment was conducted study the effects of irrigation fertilization quota on yield, berry quality, use efficiency (WUE) partial factor productivity fertilizer (PFPF). Nine treatments were set up based combinations three levels rates. The 100...
Idiopathic pulmonary fibrosis is a chronic and progressive fibrotic lung disorder with unknown etiology high mortality rate. Tanshinone ⅡA (Tan ⅡA) lipophilic diterpene extracted from the Chinese herb Salvia miltiorrhiza Bunge diverse biological functions. The present study was conducted to evaluate effects of Tan on bleomycin (BLM)‑induced in rats. Rats received an intraperitoneal injection normal rats were used as controls. Severe edema, inflammation observed BLM‑treated counts total...
Idiopathic pulmonary fibrosis is a progressive and lethal form of interstitial lung disease that lacks effective therapies at present. Glycyrrhizic acid (GA), natural compound extracted from traditional Chinese herbal medicine Glycyrrhiza glabra, was recently reported to benefit injury liver in animal models, yet whether GA has therapeutic effect on unknown. In this study, we investigated the potential rat model with bleomycin (BLM)-induced fibrosis. The results indicated treatment...
The prevalence of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (E. coli) is increasing rapidly in both hospital environments and animal farms. A lot manure has been directly applied into arable fields developing countries. But the impact ESBL-positive bacteria from on agricultural sparse, especially rural regions Tai'an, China. Here, we collected 29, 3, 10 ESBL-producing E. pig manure, compost, soil samples, respectively. To track ESBL-harboring soil, these isolates...
Background Mesenteric lymph nodes (MLNs) are critical draining of the immune system that accommodate more than half body’s lymphocytes, suggesting their potential value as a cancer immunotherapy target. Therefore, efficient delivery immunomodulators to MLNs holds great for activating responses and enhancing efficacy antitumor immunotherapy. Self-microemulsifying drug systems (SMEDDS) have attracted increasing attention improving oral bioavailability by taking advantage intestinal lymphatic...
As one of the most investigated organic compounds, phthalocyanines (Pcs) exhibit a stronger optical limiting response that can be used to protect human eyes, elements, and sensors from intense laser pulses, however, they tend aggregate at high concentration. This aggregation usually adds relaxation pathways, shorten excited state lifetime, reduce effective nonlinear absorption. A best strategy for reducing intermolecular interactions between Pc molecules is introduce more or less bulky axial...