A5101724396- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Adipose Tissue and Metabolism
- Drug-Induced Hepatotoxicity and Protection
- Air Quality and Health Impacts
- Immune Response and Inflammation
- Liver physiology and pathology
- Pharmacological Effects of Natural Compounds
- Climate Change and Health Impacts
- Kruppel-like factors research
- Medical Imaging and Pathology Studies
- Genomics, phytochemicals, and oxidative stress
- Hepatitis C virus research
- Ovarian function and disorders
- Liver Disease and Transplantation
- Lipid metabolism and biosynthesis
- Diet and metabolism studies
- Connective Tissue Growth Factor Research
- Ovarian cancer diagnosis and treatment
- Cancer, Lipids, and Metabolism
- NF-κB Signaling Pathways
- Angiogenesis and VEGF in Cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Metabolism and Genetic Disorders
- Adipokines, Inflammation, and Metabolic Diseases
Xinjiang University
2024
Obstetrics and Gynecology Hospital of Fudan University
2017-2024
University of Maryland, Baltimore
2012-2023
Shanghai Children's Medical Center
2020-2022
Shanghai Jiao Tong University
2020-2022
Shenyang Pharmaceutical University
2015-2020
University of Maryland Medical Center
2014-2018
Cedars-Sinai Medical Center
2013-2016
University of California, Los Angeles
2016
Anhui Medical University
2005-2012
Exposure to ambient fine particulate matter (PM2.5) correlates with abnormal glucose homeostasis, but the underlying biological mechanism has not been fully understood. The gut microbiota is an emerging crucial player in homeostatic regulation of metabolism. Few studies have investigated its role PM2.5 exposure-induced abnormalities homeostasis. C57Bl/6J mice were exposed filtered air (FA) or concentrated (CAP) for 12 months using a versatile aerosol concentration enrichment system (VACES)...
GOAL/BACKGROUND: Hepatoprotective effects of silymarin in patients with alcoholic liver disease are controversial. For strict control, this was assessed non-human primates. STUDY Twelve baboons were fed alcohol or without for 3 years a nutritionally adequate diet.Silymarin opposed the alcohol-induced oxidative stress (assessed by plasma 4-hydroxynonenal) and rise lipids circulating ALT. Alcohol also increased hepatic collagen type I 50% over significant mRNA alpha1 (I) procollagen, both...
Epidemiological studies link ambient fine particulate matter (PM2.5) pollution to abnormalities in the male reproductive system. However, few toxicological have investigated this potentially important adverse effect of PM2.5 pollution. Therefore, present study, we analyzed effects exposure on spermatogenesis and hypothalamic-pituitary-gonadal (HPG) axis a murine model. Fourteen C57BL/6J mice were subjected 4-month filtered air or concentrated (CAP). Their sperm count, testicular histology,...
Breast cancer is the second most lethal in women. Understanding biological mechanisms that cause progression of this disease could yield new targets for prevention and treatment. Recent experimental studies suggest brown adipose tissue (BAT) may play a key role breast progression. The primary objective pilot study was to determine if prevalence active BAT patients with increased compared other malignancies. We retrospectively analyzed data from 96 who had FDG PET/CT scan routine staging at...
Background: Exposure to ambient fine particulate matter (PM2.5) is associated with cardiovascular mortality, but underlying pathophysiologic mechanisms are not fully understood. Hypothalamic inflammation, characterized by the activation of Inhibitor kappaB kinase 2/Nuclear factor (IKK2/NF-κB) signaling pathway, may play an important role in pathogenesis diseases. We recently demonstrated that hypothalamic inflammation increased mice exposed concentrated PM2.5 (CAP). Objectives: In present...
Background: Adipose differentiation‐related protein (ADRP) is a lipid droplet‐associated that coats cytoplasmic droplets. The present study evaluated whether alcohol feeding enhances ADRP expression and droplet marker in alcoholic fatty liver of rats. Because medium‐chain triglycerides (MCT) reduce hepatosteatosis, their effects on were also evaluated. Methods: Fatty was induced rats by the consumption Lieber‐DeCarli liquid diet with or without replacement long‐chain (LCT) MCT (32%...
Liver fibrosis is a serious, life-threatening disease with high morbidity and mortality that result from diverse causes. biopsy, considered the "gold standard" to diagnose, grade, stage liver fibrosis, has limitations in terms of invasiveness, cost, sampling variability, inter-observer dynamic process fibrosis. Compelling evidence demonstrated all stages are reversible if injury removed. There clear need for safe, effective, reliable non-invasive assessment modalities determine order manage...
Yes-associated protein (YAP), a central effector in the Hippo pathway, is involved regulation of organ size, stem cell self-renewal, and tissue regeneration. In this study, we observed YAP activation patients with alcoholic steatosis, hepatitis, cirrhosis. Accumulation nucleus was also murine livers that were damaged after chronic-plus-single binge or moderate ethanol ingestion combined carbon tetrachloride intoxication (ethanol/CCl4). To understand role transcriptional coactivator...
// Liuyi Dong 1, * , Ye Yuan 2, Cynthia Opansky 1 Yiliang Chen Irene Aguilera-Barrantes 3 Shiyong Wu 2 Rong Qi Cao 4 Yee Chung Cheng 5 Daisy Sahoo Roy L. Silverstein Bin Ren Blood Research Institute, Center of Wisconsin, Milwaukee, USA Edison Biotechnology Institute and Department Chemistry Biochemistry, Ohio University, Athens, Ohio, Pathology, Medical College Diagnostic Radiology Nuclear Medicine, University Maryland Center, Baltimore, Maryland, These authors contributed equally to this...
Abstract Liver fibrosis is the common outcome of many chronic liver diseases, resulting from altered cell-cell and cell-matrix interactions that promote hepatic stellate cell (HSC) activation excessive matrix production. This study aimed to investigate functions cellular communication network factor 2 (CCN2)/Connective tissue growth (CTGF), an extracellular signaling modulator CYR61/CTGF/Nov (CCN) family, in fibrosis. Tamoxifen-inducible conditional knockouts mice hepatocyte-specific...
The relationship between the development of acute hepatitis and production TNF-alpha IFN-gamma IL-6 by liver-associated T lymphocytes following intravenous injection concanavalin A (Con A) was studied in rats. Following a single Con A, there dose time-dependent correlation serum levels alanine aminotransferase (ALT), IL-6, TNF-alpha. These increases correlated with an increase numbers CD4+, CD8+ CD25+ cells blood CD4+ liver perfusate, but not perfusate. Increased were constitutively produced...
Background: Chronic alcohol consumption is known to induce cytochrome P450 2E1 (CYP2E1) leading lipid peroxidation, mitochondrial dysfunction and hepatotoxicity. We showed that replacement of dietary long‐chain triglycerides (LCT) by medium‐chain (MCT) could be protective. now wondered whether the induction CYP2E1 plays a role liver injury avoided through intervention. Methods: Rats were fed 4 different isocaloric liquid diets. The control group received our standard dextrin‐maltose diet...
The mechanism of systemic spread H5N1 virus in patients with avian influenza is unknown. Here, nucleoprotein and hemagglutinin were identified by immunohistochemistry the nucleus cytoplasm neutrophils placental blood a pregnant woman. Viral RNA was detected situ hybridization enhanced real-time polymerase chain reaction. Therefore, may serve as vehicle for viral replication transportation influenza.
Environmental stressors that encounter in early-life and cause abnormal fetal and/or neonatal development may increase susceptibility to non-communicable diseases such as diabetes. Maternal exposure ambient fine particulate matter (PM2.5) is associated with various abnormalities, suggesting it program offspring's In the present study, we therefore examined whether maternal diesel exhaust PM2.5 (DEP), one of major sources urban areas, programs adult glucose metabolism. Female C57Bl/6J mice...
Cryptotanshinone (CRY) has been demonstrated to reverse reproductive disorders. However, whether CRY is effective in the treatment of polycystic ovary syndrome (PCOS) remains unknown. The aim present study was evaluate therapeutic potential PCOS. A rat model PCOS established by daily injection human chorionic gonadotropin and insulin for 22 days. Total body weight ovarian weight, as well levels luteinizing hormone (LH) LH follicle‑stimulating (FSH) ratio (LH/FSH) significantly increased rats...
Ambient fine particulate matter (PM2.5) exposure correlates with adverse cardiometabolic effects. The underlying mechanisms have not yet been fully understood. Hypothalamic-pituitary-adrenal (HPA) axis, as the central stress response system, regulates homeostasis and is implicated in progression of various health effects caused by inhalational airborne pollutant exposure. In this study, we investigated whether ambient PM2.5 activates HPA axis its effect mediating PM2.5-induced pulmonary...