A5050950616- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Liver physiology and pathology
- MicroRNA in disease regulation
- Adenosine and Purinergic Signaling
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Genomics, phytochemicals, and oxidative stress
- Eicosanoids and Hypertension Pharmacology
- Endoplasmic Reticulum Stress and Disease
- Circular RNAs in diseases
- Drug-Induced Hepatotoxicity and Protection
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Natural product bioactivities and synthesis
- Pediatric Hepatobiliary Diseases and Treatments
- Acute Kidney Injury Research
- Genetics and Neurodevelopmental Disorders
- Inflammasome and immune disorders
- RNA Research and Splicing
- Cannabis and Cannabinoid Research
- Cancer-related gene regulation
- Hepatitis B Virus Studies
- Tea Polyphenols and Effects
Anhui Medical University
2016-2025
Nankai University
2025
Ministry of Education of the People's Republic of China
2014-2023
Oil Crops Research Institute
2015
Chinese Academy of Agricultural Sciences
2015
Jilin University
2013
Chinese Academy of Medical Sciences & Peking Union Medical College
2009
Cisplatin is a classic chemotherapeutic agent widely used to treat different types of cancers including ovarian, head and neck, testicular uterine cervical carcinomas. However, cisplatin induces acute kidney injury by directly triggering an excessive inflammatory response, oxidative stress programmed cell death renal tubular epithelial cells. All which lead higher mortality rates in patients. In this study we examined the protective effect protocatechuic aldehyde (PA) vitro cisplatin-treated...
Hepatic stellate cell (HSC) activation is an essential event during alcoholic liver fibrosis. Evidence suggests that adenosine aggravates fibrosis via the A2A receptor (A2AR). Caffeine, which being widely consumed daily life, inhibits action of adenosine. In this study, we attempted to validate hypothesis caffeine influences acetaldehyde-induced HSC by acting on A2AR. Acetaldehyde at 50, 100, 200, and 400 μM significantly increased HSC-T6 cells proliferation, proliferation reached a maximum...