A5072727522- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Atherosclerosis and Cardiovascular Diseases
- Monoclonal and Polyclonal Antibodies Research
- Rheumatoid Arthritis Research and Therapies
- Cancer-related molecular mechanisms research
- Psoriasis: Treatment and Pathogenesis
- Fermentation and Sensory Analysis
- Immune Response and Inflammation
- HIV/AIDS Research and Interventions
- Circular RNAs in diseases
- Diabetes and associated disorders
- Autoimmune and Inflammatory Disorders Research
- MicroRNA in disease regulation
- IL-33, ST2, and ILC Pathways
- interferon and immune responses
- Galectins and Cancer Biology
- Inflammasome and immune disorders
- HIV, Drug Use, Sexual Risk
- Systemic Sclerosis and Related Diseases
- Adolescent Sexual and Reproductive Health
- Dermatology and Skin Diseases
- Lymphoma Diagnosis and Treatment
Anhui Medical University
2016-2025
Guangxi Academy of Agricultural Science
2021-2025
Anhui University of Science and Technology
2023-2025
Anhui University
2024-2025
Guangzhou University
2025
China National Petroleum Corporation (China)
2012-2024
Institute of Occupational Safety
2023
Cancer Research And Biostatistics
2023
Nanjing University
2008-2023
Shenzhen Third People’s Hospital
2023
Systemic lupus erythematosus is a complex and potentially fatal autoimmune disease, characterized by autoantibody production multi-organ damage. By genome-wide association study (320 patients 1,500 controls) subsequent replication altogether involving total of 3,300 Asian SLE from Hong Kong, Mainland China, Thailand, as well 4,200 ethnically geographically matched controls, genetic variants in ETS1 WDFY4 were found to be associated with (ETS1: rs1128334, P = 2.33×10−11, OR 1.29; WDFY4:...
Systemic lupus erythematosus (SLE) is a complex autoimmune disease with strong genetic predisposition, characterized by an upregulated type I interferon pathway. MicroRNAs are important regulators of immune homeostasis, and aberrant microRNA expression has been demonstrated in patients diseases. We recently identified miR-146a as negative regulator the pathway linked abnormal activation this to underexpression SLE patients. To explore why reduced patients, we conducted short parallel...
The observational association between gut microbiome and systemic lupus erythematosus (SLE) has been well documented. However, whether the is causal remains unclear. present study used publicly available genome-wide (GWAS) summary data to perform two-sample Mendelian randomization (MR), aiming examine links SLE. Two sets of MR analyses were conducted. A group single nucleotide polymorphisms (SNPs) that less than statistical significance threshold (5 × 10-8) served as instrumental variables....
Background: Evidence for a potential link between air pollution and rheumatoid arthritis (RA) is inconsistent, the modified effect of genetic susceptibility on relationship RA has not been well studied. Objective: Using general population cohort from UK Biobank, this study aimed to investigate associations various pollutants risk incident further estimate impact combined exposure ambient developing under modification predisposition. Methods: A total 342,973 participants with completed...
Despite increasing evidence that long non-coding RNAs (lncRNAs) widely take part in human diseases, the role of lncRNAs systemic lupus erythematosus (SLE) is largely unknown. In this study, we performed a two-stage study to explore plasma levels five (GAS5, linc0949, linc0597, HOTAIRM1 and lnc-DC) their potential as SLE biomarkers. Compared with healthy controls, GAS5 lnc-DC were significantly decreased (P < 0.001 P = 0.002, respectively) while linc0597 overexpressed patients 0.001). When...
Objective Previous observational studies demonstrated that a subset of patients with systemic lupus erythematosus (SLE) have markedly short telomere length in leukocytes. This study was undertaken to test whether leukocyte is causally associated risk SLE. Methods A 2‐sample Mendelian randomization (MR) analysis conducted estimate causality on SLE European populations. replication MR using Asian genetic data also conducted. reverse then performed the effects length. The autoantibodies...