A5102857675- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Advanced Neural Network Applications
- Advanced Vision and Imaging
- Urticaria and Related Conditions
- Adrenal Hormones and Disorders
- COVID-19 diagnosis using AI
- Dialysis and Renal Disease Management
- Monoclonal and Polyclonal Antibodies Research
- Climate Change and Health Impacts
- Diabetes and associated disorders
- Cancer-related molecular mechanisms research
- Air Quality and Health Impacts
- Chronic Lymphocytic Leukemia Research
- Higher Education and Teaching Methods
- Circadian rhythm and melatonin
- Adipokines, Inflammation, and Metabolic Diseases
- Image Enhancement Techniques
- Cardiac Health and Mental Health
- Thermoregulation and physiological responses
- Global Health Care Issues
- CCD and CMOS Imaging Sensors
- Genetic Associations and Epidemiology
- Advanced Image Processing Techniques
Second Hospital of Anhui Medical University
2015-2025
Anhui Medical University
2015-2025
Dalian Jiaotong University
2008-2024
Baotou Medical College
2022
Xuzhou Medical College
2016-2021
National University of Defense Technology
2019-2020
China Three Gorges University
2003-2009
The observational association between gut microbiome and systemic lupus erythematosus (SLE) has been well documented. However, whether the is causal remains unclear. present study used publicly available genome-wide (GWAS) summary data to perform two-sample Mendelian randomization (MR), aiming examine links SLE. Two sets of MR analyses were conducted. A group single nucleotide polymorphisms (SNPs) that less than statistical significance threshold (5 × 10-8) served as instrumental variables....
Despite increasing evidence that long non-coding RNAs (lncRNAs) widely take part in human diseases, the role of lncRNAs systemic lupus erythematosus (SLE) is largely unknown. In this study, we performed a two-stage study to explore plasma levels five (GAS5, linc0949, linc0597, HOTAIRM1 and lnc-DC) their potential as SLE biomarkers. Compared with healthy controls, GAS5 lnc-DC were significantly decreased (P < 0.001 P = 0.002, respectively) while linc0597 overexpressed patients 0.001). When...
Abstract Objectives Several studies have reported increased serum/plasma adiponectin levels in SLE patients. This study was performed to estimate the causal effects of circulating on SLE. Methods We selected nine independent single-nucleotide polymorphisms that were associated with (P &lt; 5 × 10−8) as instrumental variables from a published genome-wide association (GWAS) meta-analysis. The corresponding between and outcome (SLE) obtained an GWAS analysis, including 7219 cases 15 991...
Abstract Background The liver is an important organ that undertakes the metabolic function of human body. Liver cancer has become one cancers with highest mortality. In clinic, it work to extract region accurately before diagnosis and treatment lesions. However, manual segmentation a time-consuming boring process. Not only that, but results usually varies from person due different experience. order assist in clinical automatic segmentation, this paper proposes U-shaped network multi-scale...
Chronic kidney disease(CKD) is one of the most prevalent non-communicable health concerns in children and adolescents worldwide; however, data on its incidence, prevalence, disability-adjusted life years (DALYs) trends population are limited. We aimed to assess global, regional national CKD burden adolescents.
Answer selection, as a crucial method for intelligent medical service robots, has become more and important in natural language processing (NLP). However, there are still some critical issues the answer selection model. On one hand, model lacks semantic understanding of long questions because noise information question–answer (QA) pair. other researchers combine two or neural network models to improve quality selection. these focus on similarity between answers without considering background...
Background: Chronic kidney disease-associated pruritus (CKD-aP) is very common and sometimes refractory to treatment in hemodialysis patients. In a trial conducted Japan, nalfurafine, effectively reduced itching of treatment-resistant CKD-aP. Our present bridging study aimed evaluate the efficacy safety nalfurafine Chinese cohort with CKD-aP.Methods: this phase III, multicenter at 22 sites China, 141 cases CKD-aP were randomly (2:2:1) assigned receive 5 μg, 2.5 μg or placebo orally for 14...
The response to glucocorticoids (GCs) for patients with systemic lupus erythematosus (SLE) is characterized by wide interindividual variability, a significant number of who have no response. We analyzed whether genetic polymorphisms within glucocorticoid receptor (GR) gene are related variability in the efficacy GCs Chinese population SLE. A cohort 220 SLE was studied. These were treated (prednisone) 12 weeks. measured scores on disease activity index (SLEDAI). Patients classified into two...
Heat shock protein 90 (HSP90) is an important glucocorticoid receptor (GR) chaperone protein, and supposed to be the key factor in regulating glucocorticoids (GCs) effects. The aim of present study was explore whether single nucleotide polymorphisms (SNPs) within HSP90AA1 gene affect response systemic lupus erythematosus (SLE) patients GCs treatment. Two hundred forty-five SLE were treated with (prednisone) for 12 weeks. disease activity index (SLEDAI) used assess treatment, classified into...
Abstract TBX21 recode T-bet which is an important transcription factor that drives the Th1 immune response primarily by promoting expression of interferon-gamma ( IFNG ) gene. Recent studies have shown genetic variants in and are connected with risk systemic lupus erythematosus (SLE). The aim present study was to replicate these associations SLE Anhui Chinese population. Genotyping 3 (rs4794067 , rs2069705 rs2069718 performed. A total 3732 subjects were included final analysis. only...
Introduction: Observational studies have shown that obesity is a risk factor for various autoimmune diseases. However, the causal relationship between and diseases unclear. Mendelian randomization (MR) was used to investigate effects of on 15 Methods: MR analysis employed instrumental variables, specifically single-nucleotide polymorphisms associated with measures such as body mass index (BMI), waist circumference, hip waist-to-hip ratio. The study utilized UK Biobank FinnGen data estimate...
Macrophage-mediated inflammation is closely linked to the pathogenesis of acute kidney injury (AKI) and shift macrophages a pro-inflammatory phenotype being reliant on glycolytic metabolism. Galloflavin, polyphenol derived from tea, functions as lactate dehydrogenase A (LDHA) inhibitor, effectively obstructing metabolic pathways. However, specific immunometabolic regulatory galloflavin in remain unclear. Here, we observed that drives alleviation metabolism levels lipopolysaccharide...
To determine the effects of roxadustat on calcification when treating renal anemia in end-stage kidney disease (ESKD) patients. A prospective cohort study enrolled participants with ESKD that either received or no treatment. The primary outcome was change degree hydroxyapatite (HAP) crystals deposition. secondary propensity, a measure calcification, allowing an evaluation conversion process from to calciprotein particles. total 205 patients were enrolled, and 187 (91.2%) completed follow-up...
Objective: To construct and verify a predictive model for circadian syndrome (CircS) among middle-aged elderly adults. Methods: A total of 5,977 individuals from the China Health Retirement Longitudinal Study were enrolled. The least absolute shrinkage selection operator method was used to identify potential features multivariable logistic regression analyses. nomogram created utilizing chosen predictors. nomogram's discrimination, performance, clinical applicability evaluated using area...