A5102893498- Bone Tissue Engineering Materials
- Epoxy Resin Curing Processes
- Advanced machining processes and optimization
- Fiber-reinforced polymer composites
- Cytomegalovirus and herpesvirus research
- Electrospun Nanofibers in Biomedical Applications
- Manufacturing Process and Optimization
- Metal and Thin Film Mechanics
- Higher Education and Teaching Methods
- Advanced Surface Polishing Techniques
- Analytical Chemistry and Sensors
- Herpesvirus Infections and Treatments
- Graphene and Nanomaterials Applications
- Immune Cell Function and Interaction
- Lexicography and Language Studies
- Geoscience and Mining Technology
- Photopolymerization techniques and applications
- 3D Printing in Biomedical Research
- biodegradable polymer synthesis and properties
- Hydrocarbon exploration and reservoir analysis
- Dialysis and Renal Disease Management
- Microfluidic and Capillary Electrophoresis Applications
- interferon and immune responses
- Advanced Machining and Optimization Techniques
- Chronic Kidney Disease and Diabetes
Beijing University of Chemical Technology
2013-2024
Institute of Geology, China Earthquake Administration
2024
Qingdao University
2024
Affiliated Hospital of Qingdao University
2024
Hubei Academy of Agricultural Sciences
2016-2024
Ningxia Medical University
2019-2024
China Earthquake Administration
2024
Jinan University
2018-2023
Shihezi University
2023
Shaoxing University
2022
Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates serum LDL cholesterol (LDL-C) by interacting with the receptor (LDLR) and is an attractive therapeutic target for LDL-C lowering. We have generated a neutralizing anti-PCSK9 antibody, mAb1, that binds to epitope on PCSK9 adjacent region required LDLR interaction. In vitro, mAb1 inhibits binding attenuates PCSK9-mediated reduction in protein levels, thereby increasing uptake. A combination of statin increases levels HepG2 cells...
Abstract Titanium and its alloys are attractive materials due to their unique high strength-weight ratio that is maintained at elevated temperatures exceptional corrosion resistance. The major application of titanium has been in the aerospace industry. However, focus shift market trends from military commercial industry also reported. On Other hand, notorious for poor thermal properties classified as difficult-to-machine materials. These limit use these especially markets where cost much...
Infections caused by pathogens colonization at wound sites in the process of bone healing are considered as one major reasons for failure guided regeneration (GBR). The objective this study was to prepare a novel asymmetric collagen/chitosan GBR membrane containing minocycline-loaded chitosan nanoparticles. morphologies membranes and nanoparticles were observed SEM TEM, respectively. characterization biocompatibility evaluated. effect on assessed using critical-size cranial defect model. TEM...
Although digitalisation brings important possibilities to banking & finance service, implementing digital technologies in practices can be challenging. Indeed, the adoption of new innovative technology sector lags behind other business sectors. Many valuable finance-related have not been adopted relation strategic implications decisions domains such as development service innovation and personalization, value co-creation, marketing strategies. In particular, there is a paucity research using...
Abstract Native bone inherently requires a balanced ionic microenvironment to maintain homeostasis. Hence, scaffolds designed for the sustained release of therapeutic ions into defects hold great promise regeneration. Magnesium (Mg) and silicon (Si) are essential elements, which play crucial roles in process regeneration, impacting immunomodulation, angiogenesis, osteogenesis. Herein, porous cryogel‐type organic–inorganic composite microspheres developed as injectable microscaffolds (denoted...
A glucose sensor comprising a reflection hologram incorporated into thin, acrylamide hydrogel film bearing the cis-diol binding ligand, 3-acrylamidophenylboronic acid (3-APB), is described. The diffraction wavelength (color) of changes as polymer swells upon cis-diols. effect various concentrations glucose, variety mono- and disaccharides, α-hydroxy acid, lactate, on holographic response was investigated. displayed reversible in function concentration, with sensitivity system being dependent...
In this study, 2-acrylamidophenylboronate (2-APB) was synthesised and its ability to bind with glucose investigated both in solution when integrated into a holographic sensor. Multiple forms of 2-APB, resulting from the neighbouring effect amido group boronic acid through an intramolecular B--O-coordinated interaction, were shown exist by using multinuclear NMR spectrometry. It found that 2-APB predominantly adopts zwitterionic tetrahedral form at physiological pH values. The complex...
Chronic post-traumatic and postoperative osteomyelitis is a refractory disease which results in significant morbidity mortality. The effect of combination therapy with vancomycin-loaded calcium sulfate polymethyl methacrylate (PMMA) was unknown. Fifty-one patients suffering from chronic or the lower extremities were included retrospective investigation. assigned to study group antibiotic-loaded PMMA control PMMA. Hematological parameters, eradication infection, rate infection recurrence...
Measurement of blood l-lactate is used to assess and monitor exercise performance in sports medicine. This report describes the initial development a holographic sensor, which employs synthetic receptor, enable selective continuous real-time measurement for eventual vivo application. Three boronic acid-based receptors have been synthesized, integrated into thin acrylamide hydrogel films, then subsequently transformed sensors. Changes replay wavelength sensors were characterize swelling...
Tool condition monitoring (TCM) is an important aspect of based maintenance (CBM) in all manufacturing processes. Recent work on TCM has generated significant successes for a variety cutting operations. In particular, lower cost and on-board sensors conjunction with enhanced signal processing capabilities improved networking permitted enhancements to capabilities. This paper presents overview drilling, turning, milling, grinding. The focus this the hardware algorithms that have demonstrated...
Fabricating concurrently stretchable and conductive hydrogel scaffold is highly desired in the development of myocardial tissue engineering, also very challenging especially with anisotropic properties. Existing anisotropic-strategies are limited to specific nanomaterials, or time-consuming. Here, we present a simple new stretch-induced strategy make nanotubes aligned hydrogel. With this strategy, fabricated type hybrid that possesses excellent stretchability while enabling outstanding...
Natural bone tissue possesses inherent electrophysiological characteristics, displaying conductivity and piezoelectricity simultaneously; hence, the reconstruction of local electrical microenvironment at defect site provides an effective strategy to enhance osteogenesis. Herein, a composite cryogel-type scaffold (referred as Gel-PD-CMBT) is developed for regeneration, utilizing gelatin (Gel) in combination with conductive poly(ethylene dioxythiophene)/polystyrene sulfonate matrix Ca/Mn...
Abstract Holographic sensors for monitoring glucose were fabricated from hydrogel films containing chemical ligands based on phenylboronic acid. The transformed into reflection holograms using a diffusion method coupled with exposure to laser light. diffraction wavelength of the was used monitor swelling film in presence glucose. Fully reversible changes demonstrated, highlighting potential these as sensors. Copyright © 2004 John Wiley & Sons, Ltd.
Interferon-γ (IFN-γ) represents one of the most important innate immunity responses in a host to combat infections many human viruses including herpesviruses. Human N-myc interactor (Nmi) protein, which has been shown interact with signal transducer and activator transcription (STAT) proteins STAT1, is for activation IFN-γ induced STAT1-dependent genes responsible immune responses. However, no encoded by herpesviruses have reported Nmi inhibit Nmi-mediated achieve evasion from In this study,...
The yeast Kloeckera apiculata strain 34–9 is an antagonist that shows biological control activity against the postharvest fungal pathogens of citrus. An antifungal compound, 2-phenylethanol (PEA), has been identified from extract K. apiculata. To better understand molecular processes underlying response citrus fruit tissue to apiculata, and PEA, microarray analyses were performed on navel oranges using Affymetrix Citrus GeneChip. As many as 801, 339 608 differentially expressed genes (DEGs)...
This study intends to improve the antibacterial and mineralization performance of photocurable dental resin composites (DRCs) reduce possibility repair failure caused by secondary caries. To end, functionalized hydroxyapatite (HAp), including Zn-doped (Zn/HAp) Sr-doped HAp (Sr/HAp), were added into bisphenol A glycidyl methacrylate triethylene glycol dimethacrylate mixture, providing DRCs with capacity, respectively. By controlling total amount inorganic filler at 70 wt%, these powders...
Abstract Boronic acids have been used as receptors for the detection of diols and α‐hydroxy acids. The incorporation 3‐acrylamide phenyl boronic acid (3‐APB) into a hydrogel generates suitably responsive fully reversible holographic sensor L ‐lactate. However, it was also found that use 3‐APB resulted in being towards number other compounds containing two hydroxy groups. This report details further investigation reaction between ‐lactate three acid‐based receptors, both holograms solution,...