A5100695823- RNA Interference and Gene Delivery
- Cytomegalovirus and herpesvirus research
- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Herpesvirus Infections and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Scoliosis diagnosis and treatment
- RNA and protein synthesis mechanisms
- Immunotherapy and Immune Responses
- Genetic Mapping and Diversity in Plants and Animals
- Plant Ecology and Soil Science
- Advanced biosensing and bioanalysis techniques
- Immune Cell Function and Interaction
- Soil Carbon and Nitrogen Dynamics
- Postharvest Quality and Shelf Life Management
- Spinal Fractures and Fixation Techniques
- Medical Imaging and Analysis
- Diabetes Treatment and Management
- Toxoplasma gondii Research Studies
- Environmental and Agricultural Sciences
- CAR-T cell therapy research
- Neuroscience and Neuropharmacology Research
- Chemical Synthesis and Analysis
- Forest, Soil, and Plant Ecology in China
- Viral gastroenteritis research and epidemiology
Xinjiang Medical University
2013-2025
Fifth Affiliated Hospital of Xinjiang Medical University
2019-2025
Tsinghua University
2022-2025
Nanjing University
2024-2025
State Key Laboratory of Pollution Control and Resource Reuse
2024-2025
First People's Hospital of Yunnan Province
2015-2025
Jinan University
2013-2024
People's Hospital of Xinjiang Uygur Autonomous Region
2013-2024
Shenyang Agricultural University
2022-2024
Fudan University
2018-2024
Rationale: Messenger RNA (mRNA) vaccine outperforms other kinds of cancer immunotherapy due to its high response rates, easy preparation, and wide applicability, which is considered as one the most promising forms next-generation therapies.However, inherent instability insufficient protein expression duration mRNA limit efficacy widespread application vaccine.Methods: Here, we first tested possibility a novel circular (circRNA) platform for compare with linear RNA.Then, developed lipid...
As a cool season crop, wheat (Triticum aestivum L.) has an optimal daytime growing temperature of 15 °C during the reproductive stage. With global climate change, heat stress is becoming increasingly severe constraint on production. In this review, we summarize recent progress in understanding molecular mechanisms tolerance wheat. We firstly describe impact morphology and physiology its potential effect agronomic traits. then review discoveries determining genetic factors affecting...
Abstract Insufficient accumulation of lipid nanoparticles (LNPs)‐based mRNA vaccines in antigen presenting cells remains a key barrier to eliciting potent antitumor immune responses. Herein, we develop dendritic (DCs) targeting LNPs by taking advantage mannose receptor‐mediated endocytosis. Efficient delivery DCs is achieved vitro and vivo utilizing the sweet (STLNPs‐Man). Intramuscular injection vaccine (STLNPs‐Man@mRNA OVA ) results four‐fold higher uptake comparison with commercially used...
Abstract The rapid success of RNA vaccines in preventing SARS-CoV-2 has sparked interest their use for cancer immunotherapy. Although many cancers originate mucosal tissues, current are mainly administered non-mucosally. Here, we developed a non-invasive intranasal vaccine utilizing circular encapsulated lipid nanoparticles to induce localized immune responses. This strategy elicited potent anti-tumor T cell responses preclinical lung models while mitigating the systemic adverse effects...
Implantable neural devices that record neurons in various states, including static light activities such as walking, and vigorous running, offer opportunities for understanding brain functions dysfunctions. However, recording under remains a long-standing challenge because it leads to intense deformation. Thus, three key requirements are needed simultaneously devices, is, low modulus, specific interfacial impedance, high electrical conductivity, realize stable device/brain interfaces...
Plant peptide hormones play an important role in regulating plant developmental programs via cell-to-cell communication a non-cell autonomous manner. To characterize the biological relevance of C-TERMINALLY ENCODED PEPTIDE (CEP) genes rice, we performed genome-wide search against public databases using bioinformatics approach and identified six additional CEP members. Expression analysis revealed spatial-temporal pattern OsCEP6.1 gene different tissues at stages panicle. Interestingly,...
<b><i>Introduction:</i></b> Drug-induced acute kidney injury (D-AKI) is one of the important types AKI. The incidence D-AKI in China has rarely been studied. <b><i>Objective:</i></b> This study aims to explore disease burden, related drugs, and risk factors D-AKI. <b><i>Methods:</i></b> A nationwide cross-sectional survey was conducted adult patients from 23 academic hospitals 17 provinces China. Suspected AKI screened...
Nitric oxide (NO) is known to modulate the action of several phytohormones. This includes gaseous hormone ethylene, but molecular mechanisms underlying effect NO on ethylene biosynthesis are unclear. Here, we observed a decrease in endogenous abundance during apple (Malus domestica) fruit development and exogenous treatment with donor suppressed production, suggesting that ripening suppressor. Expression transcription factor MdERF5 was activated by treatment. induced nucleocytoplasmic...
Volatile organic compounds (VOCs) have been known to confer the flavor of fruits, characterizing quality fruits. Nanguo pear (Pyrus ussuriensis Maxim.) is widely popular among consumers due its excellent ‘fruity’ aroma derived from ester substances. Jasmonate (JAs) plays an indispensable role in formation many qualities fruit. Therefore, present study aimed explore effect jasmonate on VOCs fruit during storage. During storage, fruits were treated with various concentrations methyl (MeJA) and...
Interferon-γ (IFN-γ) represents one of the most important innate immunity responses in a host to combat infections many human viruses including herpesviruses. Human N-myc interactor (Nmi) protein, which has been shown interact with signal transducer and activator transcription (STAT) proteins STAT1, is for activation IFN-γ induced STAT1-dependent genes responsible immune responses. However, no encoded by herpesviruses have reported Nmi inhibit Nmi-mediated achieve evasion from In this study,...
Nitrogen-doped microporous carbon spheres (NMCSs) are successfully prepared via carbonization and KOH activation of phenol-formaldehyde resin polymer synthesized by a facile time-saving one-step hydrothermal strategy using triblock copolymer Pluronic F108 as soft template under the Stöber-like method condition. The influence ethanol/water volume ratios carbonation temperatures on morphologies, pore structures electrochemical performances NMCSs investigated systematically. optimal have large...
Cd-CP2 and Eu 3+ /Tb -functionalized samples were obtained for effective detection of uric acid (UA) N -acetylneuraminic (NANA).
Abstract Insufficient accumulation of lipid nanoparticles (LNPs)‐based mRNA vaccines in antigen presenting cells remains a key barrier to eliciting potent antitumor immune responses. Herein, we develop dendritic (DCs) targeting LNPs by taking advantage mannose receptor‐mediated endocytosis. Efficient delivery DCs is achieved vitro and vivo utilizing the sweet (STLNPs‐Man). Intramuscular injection vaccine (STLNPs‐Man@mRNA OVA ) results four‐fold higher uptake comparison with commercially used...
Safe, effective, and tissue-specific delivery is a central issue for the therapeutic application of nucleic-acid-based gene interfering agents, such as ribozymes siRNAs. In this study, we constructed functional RNase P-based ribozyme (M1GS RNA) that targets overlapping mRNA region M80.5 protease, two murine cytomegalovirus (MCMV) proteins essential viral replication. addition, novel attenuated strain Salmonella , which exhibited efficient transfer activity little cytotoxicity pathogenicity...