A5029663967- RNA Interference and Gene Delivery
- EEG and Brain-Computer Interfaces
- Eating Disorders and Behaviors
- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Neuroscience and Neural Engineering
- Neural and Behavioral Psychology Studies
- Land Use and Ecosystem Services
- Analog and Mixed-Signal Circuit Design
- HVDC Systems and Fault Protection
- High-Voltage Power Transmission Systems
- Blind Source Separation Techniques
- Remote Sensing and Land Use
- Luminescence and Fluorescent Materials
- Nanoparticle-Based Drug Delivery
- Orbital Angular Momentum in Optics
- Supramolecular Self-Assembly in Materials
- Obsessive-Compulsive Spectrum Disorders
- Microfluidic and Bio-sensing Technologies
- Respiratory viral infections research
- Body Image and Dysmorphia Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- SARS-CoV-2 and COVID-19 Research
- Energy Harvesting in Wireless Networks
- Functional Brain Connectivity Studies
King's College London
2023-2025
Hebei General Hospital
2025
Hebei Medical University
2025
Tsinghua University
2012-2024
Nanjing Normal University
2024
North China Electric Power University
2023-2024
Institute of Psychology, Chinese Academy of Sciences
2019-2022
University of Chinese Academy of Sciences
2014-2022
Nagoya University
2020-2022
Shandong Agricultural University
2020-2022
Abstract Dendritic cell (DC) maturation is a crucial process for antigen presentation and the initiation of T cell‐mediated immune responses. Toll‐like receptors play pivotal roles in stimulating DC promoting presentation. Here, novel message RNA (mRNA) cancer vaccine reported that boosts antitumor efficacy by codelivering an mRNA encoding tumor TLR7/8 agonist (R848) to using supramolecular lipid nanoparticles (SMLNP) as delivery platform, which new ionizable (N2‐3L) remarkably enhances...
Supramolecular nanomedicines have shown great merits in cancer therapy, but their clinical translation is hampered by monotonous therapeutic modality and unsatisfactory antitumor performance. Herein, a hybrid supramolecular polymeric nanomedicine (SNPs) developed based on β-cyclodextrin/camptothecin (CPT) host-guest molecular recognition iron-carboxylate coordination. Iron ions stabilizing SNPs catalyze the conversion of intracellular hydrogen peroxide into highly toxic hydroxyl radical...
Despite the tremendous breakthrough of immunotherapy, low response rate and resistance immune checkpoint inhibitors (ICIs) toward solid tumors occur frequently. A highly hypoxic tumor microenvironment (TME) provides cells with high concentrations HIF-1α polyamines to evade cell destruction. Reprogramming an immunogenic TME has exhibited a brilliant future boost immunotherapeutic performances. Herein, supramolecular nanomedicine (TAPP) is developed on basis host-guest molecular recognition...
Abstract Insufficient accumulation of lipid nanoparticles (LNPs)‐based mRNA vaccines in antigen presenting cells remains a key barrier to eliciting potent antitumor immune responses. Herein, we develop dendritic (DCs) targeting LNPs by taking advantage mannose receptor‐mediated endocytosis. Efficient delivery DCs is achieved vitro and vivo utilizing the sweet (STLNPs‐Man). Intramuscular injection vaccine (STLNPs‐Man@mRNA OVA ) results four‐fold higher uptake comparison with commercially used...
Lipid nanoparticles (LNPs)-based messenger RNA (mRNA) therapeutics have emerged with promising potentials in the fields of infectious diseases, cancer vaccines, and protein replacement therapies; however, their therapeutic efficacy safety can still be promoted by optimization LNPs formulations. Unfortunately, current suffer from increased production reactive oxygen species during translation, which leads to a decreased translation efficiency onset inflammation other side effects. Herein, we...
Recognition and reconstruction of residential floor plan drawings are important challenging in design, decoration, architectural remodeling fields. An automatic framework is provided that accurately recognizes the structure, type, size room, outputs vectorized 3D results. Deep segmentation detection neural networks utilized to extract room structural information. Key points network cluster analysis calculate scales rooms. The vectorization information processed through an iterative...
Polymeric cylinders, a fascinating type of nanostructures with high surface area, internal volume and rigidity, have been exploited as novel drug delivery vehicles over the past decade. However, it's still an open challenge to afford cylindrical using polymeric building blocks via traditional self-assembly processes. Herein, we report hierarchical strategy preparing aggregates (tubisomes) from amphiphilic supramolecular bottlebrush polymer in which cyclic peptide nanotube is employed...
Abstract As the most advanced non‐viral delivery system, lipid nanoparticles (LNPs) were approved by FDA, propelling advancements of gene therapy. However, their clinical applications are hampered potential immunogenicity components that trigger immune‐related adverse events, like inflammation and allergy. Herein, we formulate various dLNPs with diminished incorporating dexamethasone (Dex) into liver‐, spleen‐, lung‐targeting LNPs formulations exhibit excellent abilities to target specific...
Abstract Insufficient accumulation of lipid nanoparticles (LNPs)‐based mRNA vaccines in antigen presenting cells remains a key barrier to eliciting potent antitumor immune responses. Herein, we develop dendritic (DCs) targeting LNPs by taking advantage mannose receptor‐mediated endocytosis. Efficient delivery DCs is achieved vitro and vivo utilizing the sweet (STLNPs‐Man). Intramuscular injection vaccine (STLNPs‐Man@mRNA OVA ) results four‐fold higher uptake comparison with commercially used...
Messenger RNA (mRNA) vaccines have exhibited enormous potential in the treatment of human diseases; however, their widespread applications are curtailed by induction reactive oxygen species during mRNA translation, which greatly compromises translation efficiency. Herein, we present a robust strategy with capability to substantially enhance efficacy vaccine through promoting and stimulator interferon genes (STING) activation. The entails coassembly small-sized manganese oxide nanoparticles (Mn
Polyethylene glycol conjugation (PEGylation) is the most successful strategy to promote stability, pharmacokinetics, and efficacy of therapeutics; however, anti-PEG antibodies induced by repeated treatments raise serious concerns about future PEGylated therapeutics. In order solve "PEG dilemma", polymers with excellent water solubility biocompatibility are urgently desired attenuate generation antibodies. Here, poly(ethyl ethylene phosphate) (PEEP) degradability stealth effects used as an...
Abstract Internalization of the “thin ideal” is a risk factor for eating pathology. It unclear how pervasive thin ideal among young Chinese. In current study, 97 participants reported their subjective willingness to be and eating‐disorder‐related weight‐controlling behaviors, then finished picture judgment task implicitly detect perception importance thinness attractiveness. Hierarchical linear modeling was used analyze data. Among female participants, 79.59% wanted thinner body....
The explosion of time series advances the development databases. To reduce storage overhead in these systems, data compression is widely adopted. Most existing algorithms utilize overall characteristics entire to achieve high ratio, but ignore local contexts around individual points. In this way, they are effective for certain patterns, and may suffer inherent pattern changes real-world series. It therefore strongly desired have a method that can always ratio existence diversity. paper, we...
Abstract Unhealthy eating, a risk factor for eating disorders (EDs) and obesity, often coexists with emotional behavioral problems; however, the underlying neurobiological mechanisms are poorly understood. Analyzing data from longitudinal IMAGEN adolescent cohort, we investigated associations between behaviors, genetic predispositions high body mass index (BMI) using polygenic scores (PGSs), trajectories (ages 14–23 years) of ED-related psychopathology brain maturation. Clustering analyses...
Visible and near infrared spectroscopy has long been used to predict fruit internal quality, with portable instrumentation advantageous for in-field use. We developed a handheld spectrometer using linear variable filter (LVF) complementary metal-oxide-semiconductor (CMOS) detector array. The LVF is bandpass centre wavelength changing linearly in one direction can replace grating as the light-dispersion component. An was designed fabricated specifically work 620–1080 nm region analysis of...
Vehicular sensor network (VSN) using vehicle-based sensors is an emerging technology that can provide inexpensive solution for surveillance and urban monitoring applications. For the constantly moving vehicles, resulting in unpredictable topology, data transmission VSN vulnerable to packet losses, thus deteriorating quality. To resolve this problem, a cooperative sampling compression approach proposed. Based on compressive sensing, does not require inter-sensor communication adopts sparse...
The Body Image Concern Inventory (BICI) was developed to assess dysmorphic appearance concern and has been found be a reliable valid instrument in Western societies. To examine the psychometric properties of new Chinese BICI, BICI administered 1,231 young adults (Study 1) 47 female patients with eating disorders 56 matched controls (ED; Study 2). In study 1, Cronbach’s alpha .92 test-retest reliability .73 over 6-month interval observed for total scale. Confirmatory factor analysis supported...
The crystal structure of tris(2,2'-bipyridine)zinc(II) perchlorate, [Zn(C 10 H 8 N 2 ) 3 ](ClO 4 , has been established by X-ray crystallography. Zn II atom is coordinated three chelating 2,2'-bipyridine ligands in a highly distorted octahedral arrangement with Zn-N bond lengths ranging from 2.135 (2) to 2.172 (3) A.
The FAIR project [1] undertaken at GSI (Darmstadt, Germany) will lead to the construction of 2 superconducting synchrotrons and one fragment separator called Super-FRS. This paper presents quench measurements calculations on Super-FRS dipole using two different 3D FEM programs. first (called Opera Quench) gives same order propagation velocities as those computed with a 1D program. second (developed by CIEMAT) succeeds reproduce current drop resistance measured dipole.