Günter Schumann
A5090364896- Functional Brain Connectivity Studies
- Neurotransmitter Receptor Influence on Behavior
- Genetic Associations and Epidemiology
- Mental Health Research Topics
- Child and Adolescent Psychosocial and Emotional Development
- Advanced Neuroimaging Techniques and Applications
- Neural and Behavioral Psychology Studies
- Attention Deficit Hyperactivity Disorder
- Stress Responses and Cortisol
- Health, Environment, Cognitive Aging
- Cognitive Abilities and Testing
- Substance Abuse Treatment and Outcomes
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Genomic variations and chromosomal abnormalities
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- Schizophrenia research and treatment
- Receptor Mechanisms and Signaling
- Autism Spectrum Disorder Research
- Prenatal Substance Exposure Effects
- Neuroscience and Neuropharmacology Research
- Adipose Tissue and Metabolism
- Cannabis and Cannabinoid Research
- Memory and Neural Mechanisms
- Genomics and Rare Diseases
King's College London
2016-2025
Charité - Universitätsmedizin Berlin
2011-2025
Fudan University
2018-2025
Shanghai Center for Brain Science and Brain-Inspired Technology
2019-2025
Humboldt State University
2020-2024
Leibniz Institute for Neurobiology
2019-2024
Medical Research Council
2013-2024
Humboldt-Universität zu Berlin
2019-2024
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2024
Freie Universität Berlin
2020-2024
During rest, brain activity is synchronized between different regions widely distributed throughout the brain, forming functional networks. However, molecular mechanisms supporting connectivity remain undefined. We show that networks defined with resting-state magnetic resonance imaging can be recapitulated by using measures of correlated gene expression in a post mortem tissue data set. The set 136 genes we identify significantly enriched for ion channels. Polymorphisms this affect large...
Background and Objectives The COVID‐19 pandemic control measures may have increased the risk of abusing addictive substances as well behaviors. Methods We present an initial online survey in 6416 Chinese about relation between behavior China. Results During pandemic, 46.8% subjects reported dependence on internet use, 16.6% had longer hours use. prevalence (4.3%) severe rose up to 23% than that (3.5%) before occurred, their degree 20 times more often being declined (60% vs 3%). Relapses...
Catechol- O -methyltransferase (COMT) degrades the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. A functional polymorphism in COMT gene ( val 158 met ) accounts for a fourfold variation enzyme activity. The low-activity allele has been associated with improved working memory but higher risk anxiety-related behaviors. Using magnetic resonance imaging, we assessed effects of genotype on brain activation by standardized affective visual stimuli (unpleasant,...
Objective: The authors examined whether alterations in the brain’s reward network operate as a mechanism across spectrum of risk for depression. They then tested these are specific to anhedonia compared with low mood and they predictive depressive outcomes. Method: Functional MRI was used collect blood-oxygen-level-dependent (BOLD) responses anticipation monetary incentive task 1,576 adolescents community-based sample. Adolescents current subthreshold depression clinical were matched healthy...
The traditional view that mental disorders are distinct, categorical has been challenged by evidence highly comorbid and exist on a continuum (e.g., Caspi et al., 2014; Tackett 2013). first objective of this study was to use structural equation modeling model the structure psychopathology in an adolescent community-based sample (N = 2,144) including conduct disorder, attention-deficit/hyperactivity disorder (ADHD), oppositional-defiant (ODD), obsessive-compulsive eating disorders, substance...
Alcohol consumption is a moderately heritable trait, but the genetic basis in humans largely unknown, despite its clinical and societal importance. We report genome-wide association study meta-analysis of ∼2.5 million directly genotyped or imputed SNPs with alcohol (gram per day kilogram body weight) among 12 population-based samples European ancestry, comprising 26,316 individuals, replication genotyping an additional 21,185 individuals. SNP rs6943555 autism susceptibility candidate 2 gene...
Although lower brain volume has been routinely observed in individuals with substance dependence compared nondependent control subjects, the regions exhibiting have not consistent across studies. In addition, it is clear whether a common set of are involved regardless used or some effects specific. Resolution these issues may contribute to identification clinically relevant imaging biomarkers. Using pooled data from 14 countries, authors sought identify general and substance-specific...
Animal studies have shown that the adolescent brain is sensitive to disruptions in endocannabinoid signaling, resulting altered neurodevelopment and lasting behavioral effects. However, few investigated ties between cannabis use development humans.
Multiple lines of evidence suggest that the circadian clock contributes to pathogenesis winter depression or seasonal affective disorder (SAD). We hypothesized sequence variations in three genes, including Per2, Arntl, and Npas2, which form a functional unit at core clock, predispose depression.In silico analysis biological effects allelic differences suggested target single-nucleotide polymorphisms (SNPs) be analyzed sample 189 patients matched controls. The most relevant SNP each gene was...
Background:The pleasant effects of food and alcohol intake are partially mediated by µ-opiate receptors in the ventral striatum, a central area brain reward system.Blockade with naltrexone reduces relapse risk among some but not all alcoholic individuals.Objective: To test hypothesis that craving is pronounced individuals high availability system.Design: Patients comparison sample.The was measured vivo positron emission tomography (PET) radioligand carbon 11-labeled carfentanil striatum...
Amygdala volume has been associated with drug craving in cocaine addicts, and amygdala reduction is observed some alcohol-dependent subjects. This study sought an association subjects between volumes of reward-related brain regions, alcohol craving, the risk relapse.Besides authors assessed amygdala, hippocampus, ventral striatum 51 52 age- education-matched healthy comparison after detoxification. After imaging clinical assessment, patients were followed for 6 months intake was...
Objective: Adolescents are particularly vulnerable to addiction, and in the case of smoking, this often leads long-lasting nicotine dependence. The authors investigated a possible neural mechanism underlying vulnerability. Method: Functional MRI was performed during reward anticipation 43 adolescent smokers subjects matched on age, gender, IQ. also assessed group differences novelty seeking, impulsivity, delay discounting. Results: In relation comparison subjects, showed greater discounting...
Video game playing is a frequent recreational activity. Previous studies have reported an involvement of dopamine-related ventral striatum. However, structural brain correlates video not been investigated. On magnetic resonance imaging scans 154 14-year-olds, we computed voxel-based morphometry to explore differences between and infrequent players. Moreover, assessed the Monetary Incentive Delay (MID) task during functional Cambridge Gambling Task (CGT). We found higher left striatal grey...