A5076094759- Neurotransmitter Receptor Influence on Behavior
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Behavioral Health and Interventions
- Substance Abuse Treatment and Outcomes
- Smoking Behavior and Cessation
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Attention Deficit Hyperactivity Disorder
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Research Topics
- Memory and Neural Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Resilience and Mental Health
- Tryptophan and brain disorders
- Cannabis and Cannabinoid Research
- Mind wandering and attention
- Genetic Associations and Epidemiology
- Alcohol Consumption and Health Effects
- Impact of Technology on Adolescents
- COVID-19 and Mental Health
- Cognitive Abilities and Testing
- Prenatal Substance Exposure Effects
- Gambling Behavior and Treatments
- Stress Responses and Cortisol
- Obesity, Physical Activity, Diet
Radboud University Nijmegen
2016-2025
University Medical Center Utrecht
2021
Erasmus University Rotterdam
2010-2019
La Trobe University
2018
University of Oregon
2018
The University of Melbourne
2013-2018
University of Vermont
2018
Icahn School of Medicine at Mount Sinai
2018
Orygen
2018
Media Working Group
2018
Although lower brain volume has been routinely observed in individuals with substance dependence compared nondependent control subjects, the regions exhibiting have not consistent across studies. In addition, it is clear whether a common set of are involved regardless used or some effects specific. Resolution these issues may contribute to identification clinically relevant imaging biomarkers. Using pooled data from 14 countries, authors sought identify general and substance-specific...
Punishment doesn't work in cocaine addicts Addiction is extremely difficult to treat, particularly use disorder. Animal experiments have led the concept of drug addiction as abnormal goal-directed learning and habit formation. Ersche et al. found that overtraining with positive reinforcement such rewards made cocaine-addicted patients less sensitive outcome their actions. In contrast, on a punishment paradigm had no effect. Thus, habits may determine behavior users. Science , this issue p. 1468
Introduction The role of inhibitory control in addictive behaviors is highlighted several models behaviors. Although reduced has been observed behaviors, it inconclusive whether this evident smokers. Furthermore, proposed that drug abuse individuals with poor response inhibition may experience greater difficulties not consuming substances the presence cues. major aim current study was to provide electrophysiological evidence for smokers and investigate more pronounced during smoking cue...
Abstract Excessive computer gaming has recently been proposed as a possible pathological illness. However, research on this topic is still in its infancy and underlying neurobiological mechanisms have not yet identified. The determination of excessive might be useful for the identification those at risk, better understanding behavior development interventions. often compared with gambling substance use disorder. Both disorders are characterized by high levels impulsivity, which incorporates...
Abstract While imaging studies have demonstrated volumetric differences in subcortical structures associated with dependence on various abused substances, findings to date not been wholly consistent. Moreover, most compared brain morphology across those dependent different substances of abuse identify substance‐specific and substance‐general effects. By pooling large multinational datasets from 33 sites, this study examined surface 1628 nondependent controls 2277 individuals alcohol,...
Abstract Adolescents' risk-taking behavior has been linked to a maturational imbalance between reward ("go") and inhibitory-control ("stop")-related brain circuitry. This may drive adolescent drug-taking, such as cannabis use. In this study, we assessed the non-acute effects of use on reward-related function. We performed two-site (United States Netherlands; pooled data) functional magnetic resonance imaging (fMRI) study with cross-sectional design. Twenty-one abstinent but frequent...
Despite the current shift towards permissive cannabis policies, few studies have investigated pleasurable effects users seek. Here, we investigate of on listening to music, a rewarding activity that frequently occurs in context recreational use. We additionally tested how these are influenced by cannabidiol, which may offset cannabis-related harms.Across 3 sessions, 16 inhaled with without and placebo. compared their response music relative control excerpts scrambled sound during functional...
Harmful behavior such as smoking may reflect a disturbance in the balance of goal-directed and habitual control. Animal models suggest that control develops after prolonged substance use. In this study, we investigated whether smokers (N = 49) differ from controls 46) regulation behavior. It was also individual differences nicotine dependence levels were associated with responding.We used two different multistage instrumental learning tasks consist an phase, subsequent outcome devaluation,...
Abstract Brain asymmetry reflects left‐right hemispheric differentiation, which is a quantitative brain phenotype that develops with age and can vary psychiatric diagnoses. Previous studies have shown substance dependence associated altered structure function. However, it unknown whether structural asymmetries are different in individuals compared nondependent participants. Here, mega‐analysis was performed using collection of 22 MRI datasets from the ENIGMA Addiction Working Group....
Tobacco, alcohol and cannabis are commonly used among university students. However, student lives their substance use have changed dramatically since the start of COVID-19 pandemic. This study investigated impact on (trends in) weekly smoking, binge drinking in Dutch students associated student-, study- COVID-19-related characteristics. Between April June 2020, several higher educational institutes invited to participate an online survey. Data 9967 (Mage = 22.0 (SD 2.6); Nfemale 7008...
A small but growing neuroimaging literature has begun to examine the neural mechanisms underlying difficulty that substance-use dependent (SUD) groups have with ignoring salient, drug-related stimuli. Drug-related attentional bias appears implicate countermanding forces of cognitive control and reward salience. Basic neuroscience research suggests emotionally evocative stimuli in our environment requires both up-regulation networks down-regulation processing emotion regions. Research date...
Susceptibility to use of addictive substances may result, in part, from a greater preference for an immediate small reward relative larger delayed or insensitivity punishment. This functional magnetic resonance imaging (fMRI) study examined the neural basis inhibiting immediately rewarding stimulus obtain smokers. We also investigated whether punishment could modulate inhibitory control.The Monetary Incentive Go/NoGo (MI-Go/NoGo) task was administered that provided three types outcomes...