A5061641139- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Mental Health Research Topics
- Neural and Behavioral Psychology Studies
- Schizophrenia research and treatment
- Advanced MRI Techniques and Applications
- Genetic Associations and Epidemiology
- Tryptophan and brain disorders
- Cannabis and Cannabinoid Research
- Dementia and Cognitive Impairment Research
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Memory and Neural Mechanisms
- Alzheimer's disease research and treatments
- Bioinformatics and Genomic Networks
- Williams Syndrome Research
- Substance Abuse Treatment and Outcomes
- Health, Environment, Cognitive Aging
- Congenital heart defects research
- Behavioral Health and Interventions
- Alcohol Consumption and Health Effects
- Fractal and DNA sequence analysis
- Smoking Behavior and Cessation
- Bipolar Disorder and Treatment
Hartford Hospital
2013-2025
Hartford Financial Services (United States)
2010-2025
Yale University
2009-2023
University of Pennsylvania
2017
Mental Illness Research, Education and Clinical Centers
2017
VA Healthcare-VISN 4
2017
VA Connecticut Healthcare System
2017
Boston University
2017
Boston Public Schools
2017
Neuropsychiatric Research Institute
2010-2016
Most of what we know about antipsychotic drug effects is at the receptor level, distal from neural system that mediate their clinical efficacy. Studying cerebral function in antipsychotic-naive patients with schizophrenia before and after pharmacotherapy can enhance understanding therapeutic mechanisms these clinically effective treatments.To examine alterations regional network first-episode treatment second-generation medication.Case-control study.Huaxi MR Research Center Mental Health...
Significance Connectivity within the brain’s resting-state default mode network (DMN) has been shown to be compromised in multiple genetically complex/heritable neuropsychiatric disorders. Uncovering source of such alterations will help developing targeted treatments for these To our knowledge, this study is first attempt do so by using a multivariate data-driven fusion approach. We report five major DMN subnodes, all which were found hypo-connected probands with psychotic illnesses....
Conventional clinical neuroimaging is insensitive to axonal injury in traumatic brain (TBI). Immunocytochemical staining reveals changes morphology within hours, suggesting potential for diffusion-weighted magnetic resonance (MR) early diagnosis and management of TBI. Diffusion tensor imaging (DTI) characterizes the three-dimensional (3D) distribution water diffusion, which highly anisotropic white matter fibers owing length. Recently, DTI has been used investigate (TAI), emphasizing...
Impulsivity, often defined as a human behavior characterized by the inclination of an individual to act on urge rather than thought, with diminished regard consequences, encompasses range maladaptive behaviors, which are in turn affected distinct neural systems. Congruent above definition, behavioral studies have consistently shown that underlying construct impulsivity is multidimensional nature. However, research date has been inconclusive regarding different domains or constructs...
The study examined gray matter volume across psychosis diagnoses organized by dimensional and DSM-IV categories from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) sample.In total, 351 probands with (146 schizophrenia, 90 schizoaffective disorder, 115 psychotic bipolar I disorder), 369 of their first-degree relatives (134 were individuals 106 129 200 healthy comparison subjects assessed. Gray volumes 3-T T1-weighted images analyzed using VBM8 toolbox for SPM8, outcomes...
We quantified frequency-specific, absolute, and fractional amplitude of low-frequency fluctuations (ALFF/fALFF) across the schizophrenia (SZ)-psychotic bipolar disorder (PBP) psychosis spectrum using resting functional magnetic resonance imaging data from large BSNIP family study. assessed 242 healthy controls (HC), 547 probands (180 PBP, 220 SZ, 147 schizoaffective disorder—SAD), 410 their first-degree relatives (134 PBPR, 150SZR, 126 SADR). Following standard preprocessing in statistical...
Background Alcohol and marijuana are the two most abused substances in US colleges. However, research on combined influence (cross sectional or longitudinal) of these academic performance is currently scant. Methods Data were derived from longitudinal 2-year Brain Research College Students (BARCS) study including 1142 freshman students who completed monthly use alcohol consumption surveys. Subjects classified into data-driven groups based their consumption. A linear mixed-model (LMM) was...
Numerous neuroimaging studies report abnormal regional brain activity during working memory performance in schizophrenia, but few have examined network integration as determined by "functional connectivity" analyses.We used independent component analysis (ICA) to identify and characterize dysfunctional spatiotemporal networks schizophrenia engaged the different stages (encoding recognition) of a Sternberg fMRI paradigm. 37 chronic 54 healthy age/gender-matched participants performed modified...
Abstract While imaging studies have demonstrated volumetric differences in subcortical structures associated with dependence on various abused substances, findings to date not been wholly consistent. Moreover, most compared brain morphology across those dependent different substances of abuse identify substance‐specific and substance‐general effects. By pooling large multinational datasets from 33 sites, this study examined surface 1628 nondependent controls 2277 individuals alcohol,...
Abstract Driving while intoxicated remains a major public health hazard. is complex task involving simultaneous recruitment of multiple cognitive functions. The investigators studied the neural substrates driving and their response to different blood alcohol concentrations (BACs), using functional magnetic resonance imaging (fMRI) virtual reality simulator. We used independent component analysis (ICA) isolate spatially temporally correlated driving‐related brain circuits in 40 healthy, adult...
The anterior cingulate and several other prefrontal parietal brain regions are implicated in error processing cognitive control. effects of different doses alcohol on activity within these during a functional magnetic resonance imaging (fMRI) task where errors frequently committed have not been fully explored.This study examined the impact placebo [breath concentration (BrAC) = 0.00%], moderate (BrAC 0.05%), high 0.10%) hemodynamic MRI Go/No-Go 38 healthy volunteers.Alcohol increased...
Williams syndrome (WS) is a rare genetic neurodevelopmental disorder characterized by increased non-social anxiety, sensitivity to sounds and hypersociability. Previous studies have reported contradictory findings with regard regional brain variation in WS, relying on only one type of morphological measure (usually volume) each study. The present study aims contribute this body literature perhaps elucidate some these discrepancies examining concurrent measures cortical thickness, surface...