A5023565994- Functional Brain Connectivity Studies
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Nicotinic Acetylcholine Receptors Study
- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Advanced MRI Techniques and Applications
- Receptor Mechanisms and Signaling
- Advanced Neuroimaging Techniques and Applications
- Mental Health Research Topics
- Memory and Neural Mechanisms
- Neuropeptides and Animal Physiology
- Smoking Behavior and Cessation
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Transcranial Magnetic Stimulation Studies
- Pain Mechanisms and Treatments
- Stress Responses and Cortisol
- EEG and Brain-Computer Interfaces
- Heart Rate Variability and Autonomic Control
- Cannabis and Cannabinoid Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Forensic Toxicology and Drug Analysis
- Ion channel regulation and function
- Olfactory and Sensory Function Studies
- Schizophrenia research and treatment
National Institute on Drug Abuse
2015-2024
National Institutes of Health
2014-2024
TriNetX (United States)
2024
University of Washington
2024
Pennsylvania Hospital
2020-2021
Hospital of the University of Pennsylvania
2021
University of Cape Town
2021
South African Medical Research Council
2021
Vanderbilt University Medical Center
2021
Behavioral Pharma (United States)
2021
Normal human behavior and cognition are reliant on a person’s ability to inhibit inappropriate thoughts, impulses, actions. The temporal spatial advantages of event-related functional MRI (fMRI) were exploited identify cortical regions that showed transient change in fMRI signal after the withholding prepotent motor response. specificity design also minimized possible contamination from response inhibition errors (i. e., commission errors) other extraneous processes. Regions identified...
Cocaine-related cues have been hypothesized to perpetuate drug abuse by inducing a craving response that prompts drug-seeking behavior. However, the mechanisms, underlying neuroanatomy, and specificity of this neuroanatomy are not yet fully understood.To address these issues, experienced cocaine users (N=17) comparison subjects (N=14) underwent functional magnetic resonance imaging while viewing three separate films portrayed 1 ) individuals smoking crack cocaine, 2) outdoor nature scenes,...
The default mode network (DMN) in humans has been suggested to support a variety of cognitive functions and implicated an array neuropsychological disorders. However, its function(s) remains poorly understood. We show that rats possess DMN is broadly similar the DMNs nonhuman primates humans. Our data suggest that, despite distinct evolutionary paths between rodent primate brain, well-organized, intrinsically coherent appears be fundamental feature mammalian brain whose primary might...
Although extensive evidence exists for the reinforcing properties of drugs abuse such as cocaine, relatively less research has addressed functional neuroanatomical correlates cognitive sequelae these drugs. We present a magnetic resonance imaging study GO-NOGO task in which successful performance required prepotent behaviors to be inhibited. Significant cingulate, pre-supplementary motor and insula hypoactivity was observed both NOGOs errors commission chronic cocaine users relative...
The anterior cingulate cortex (ACC) is part of a network implicated in the development self-regulation and whose connectivity changes dramatically development. In previous studies we showed that 3 h mental training, based on traditional Chinese medicine (integrative body-mind IBMT), increases ACC activity improves self-regulation. However, it not known whether white matter can result from small amounts training. We here report 11 IBMT fractional anisotropy (FA), an index indicating integrity...
OBJECTIVE: Nicotine is a highly addictive substance, and cigarette smoking major cause of premature death among humans. Little known about the neuropharmacology sites action nicotine in human brain. Such knowledge might help development new behavioral pharmacological therapies to aid treating dependence improve cessation success rates. METHOD: Functional magnetic resonance imaging, real-time imaging technique, was used determine acute CNS effects intravenous 16 active smokers. An injection...
Synchronized low-frequency spontaneous fluctuations of the functional MRI (fMRI) signal have recently been applied to investigate large-scale neuronal networks brain in absence specific task instructions. However, underlying neural mechanisms these remain largely unknown. To this end, electrophysiological recordings and resting-state fMRI measurements were conducted α-chloralose-anesthetized rats. Using a seed-voxel analysis strategy, region-specific, anesthetic dose-dependent connectivity...
Although lower brain volume has been routinely observed in individuals with substance dependence compared nondependent control subjects, the regions exhibiting have not consistent across studies. In addition, it is clear whether a common set of are involved regardless used or some effects specific. Resolution these issues may contribute to identification clinically relevant imaging biomarkers. Using pooled data from 14 countries, authors sought identify general and substance-specific...
<h3>Importance</h3> Interactions of large-scale brain networks may underlie cognitive dysfunctions in psychiatric and addictive disorders. <h3>Objectives</h3> To test the hypothesis that strength coupling among 3 networks—salience, executive control, default mode—will reflect state nicotine withdrawal (vs smoking satiety) will predict abstinence-induced craving deficits to develop a resource allocation index (RAI) reflects combined interactions networks. <h3>Design, Setting,...
Converging evidence has long identified both impulsivity and compulsivity as key psychological constructs in drug addiction. Although dysregulated striatal-cortical network interactions have been cocaine addiction, the association between these brain networks addiction is poorly understood.To test hypothesis that associated with disturbances communication captured by resting-state functional connectivity (rsFC), measured from coherent spontaneous fluctuations blood oxygenation...
Abstract Background The glymphatic pathway transports cerebrospinal fluid through the brain, thereby facilitating waste removal. A unique aspect of this is that its function depends on state consciousness brain and associated with norepinephrine activity. current view all anesthetics will increase transport by inducing unconsciousness. This implies effect should be independent their mechanism action, as long they induce We tested hypothesis comparing supplementary dexmedetomidine, which...
Abstract Drug addiction is a public health crisis for which new treatments are urgently needed. In rare cases, regional brain damage can lead to remission. These cases may be used identify therapeutic targets neuromodulation. We analyzed two cohorts of patients addicted smoking at the time focal (cohort 1 n = 67; cohort 2 62). Lesion locations were mapped atlas and network functionally connected each lesion location was computed using human connectome data ( 1,000). Associations with...
Functional magnetic resonance imaging (FMRI) is a noninvasive technique for mapping regional brain changes in response to sensory, motor, or cognitive activation tasks. Interpretation of these experiments may be confounded by more elementary task parameters, such as stimulus presentation movement rates. We examined the effect rate on FMRI recorded from contralateral primary motor cortex. Four right-handed healthy subjects performed flexion-extension movements digits 2–5 right hand at rates...
Abstract Sustained attention deficits occur in several neuropsychiatric disorders. However, the underlying neurobiological mechanisms are still incompletely understood. To that end, functional MRI was used to investigate neural substrates of sustained (vigilance) using rapid visual information processing (RVIP) task 25 healthy volunteers. In order better understand networks attentional abilities, brain regions where task-induced activation correlated with performance were identified....
<h3>Context</h3> Understanding the mechanisms underlying nicotine addiction to develop more effective treatment is a public health priority. Research consistently shows that transiently improves multiple cognitive functions. However, using replacement treat yields generally inconsistent results. Although this dichotomy well known, reasons are unclear. Imaging studies showed challenges almost always involve cingulate cortex, suggesting locus may be key region associated with and its...
Previous functional magnetic resonance imaging (fMRI) studies with human subjects have explored the neural substrates involved in forming associations Pavlovian fear conditioning. Most of these used delay procedures, which conditioned stimulus (CS) and unconditioned (UCS) coterminate. Less is known about brain regions that support trace conditioning, a procedure an interval time (trace interval) elapses between CS termination UCS onset. work suggests significant overlap circuitry supporting...