A5039000139- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Neurological disorders and treatments
- EEG and Brain-Computer Interfaces
- Mental Health Research Topics
- Traumatic Brain Injury Research
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Treatment of Major Depression
- Electroconvulsive Therapy Studies
- Neuroscience and Neural Engineering
- Psychosomatic Disorders and Their Treatments
- Advanced MRI Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Multiple Sclerosis Research Studies
- Pain Management and Treatment
- Obsessive-Compulsive Spectrum Disorders
- Neural and Behavioral Psychology Studies
- Schizophrenia research and treatment
- Genetic Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Innovations in Medical Education
- Religion, Spirituality, and Psychology
- Attention Deficit Hyperactivity Disorder
Brigham and Women's Hospital
2020-2025
Harvard University
2017-2025
Circuit Therapeutics (United States)
2020-2025
McLean Hospital
2017-2025
Mass General Brigham
2024-2025
Champalimaud Foundation
2025
Massachusetts General Hospital
2023-2025
Brown University
2023-2024
Providence VA Medical Center
2024
Duke University
2024
Treatment of different depression symptoms may require brain stimulation targets with underlying circuits. The authors sought to identify such targets, which could improve the efficacy therapeutic and facilitate personalized therapy.The retrospectively analyzed two independent cohorts patients who received left prefrontal transcranial magnetic (TMS) for treatment (discovery sample, N=30; active replication N=81; sham N=87). Each patient's TMS site was mapped circuits using functional...
Abstract Drug addiction is a public health crisis for which new treatments are urgently needed. In rare cases, regional brain damage can lead to remission. These cases may be used identify therapeutic targets neuromodulation. We analyzed two cohorts of patients addicted smoking at the time focal (cohort 1 n = 67; cohort 2 62). Lesion locations were mapped atlas and network functionally connected each lesion location was computed using human connectome data ( 1,000). Associations with...
Importance It remains unclear why lesions in some locations cause epilepsy while others do not. Identifying the brain regions or networks associated with by mapping these could inform prognosis and guide interventions. Objective To assess whether lesion map to specific networks. Design, Setting, Participants This case-control study used location network identify a discovery data set of patients poststroke control stroke. Patients stroke (n = 76) no 625) were included. Generalizability other...
Repetitive transcranial magnetic stimulation (rTMS) has demonstrated antidepressant efficacy but limited evidence in depression associated with traumatic brain injury (TBI). Here, we investigate the use of rTMS targeted individualized resting-state network mapping (RSNM) dorsal attention (DAN) and default mode (DMN) subjects treatment-resistant concussive or moderate TBI. The planned sample size was 50 first interim analysis at 20, only 15 were enrolled before study terminated for logistical...
Depression associated with traumatic brain injury (TBI) is believed to be clinically distinct from primary major depressive disorder (MDD) and may less responsive conventional treatments. Brain connectivity differences between the dorsal attention network (DAN), default mode (DMN), subgenual cingulate have been implicated in TBI MDD. To characterize these distinctions, we applied precision functional mapping of resting-state magnetic resonance imaging data five published patient cohorts,...
Development of ready-to-use biomaterials and scaffolds is vital for further advancement scaffold-based tissue engineering in clinical practice. Scaffolds need to mimic 3D ultrastructure, have adequate mechanical strength, are biocompatible, non-immunogenic promote regeneration vivo. Although decellularization native tissues seems promising deliver that meet these criteria, hard, poorly penetrable diffusible remains challenging whilst being a very time-consuming process. In this study, method...
Abstract At the group level, antidepressant efficacy of rTMS targets is inversely related to their normative connectivity with subgenual anterior cingulate cortex (sgACC). Individualized may yield better targets, particularly in patients neuropsychiatric disorders who have aberrant connectivity. However, sgACC shows poor test–retest reliability at individual level. resting-state network mapping (RSNM) can reliably map inter-individual variability brain organization. Thus, we sought identify...