A5041908513- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Psychosomatic Disorders and Their Treatments
- Mental Health and Psychiatry
- Neurological disorders and treatments
- Healthcare Decision-Making and Restraints
- Genetic Neurodegenerative Diseases
- Psychology of Moral and Emotional Judgment
- Amyotrophic Lateral Sclerosis Research
- Advanced Neuroimaging Techniques and Applications
- Neuroethics, Human Enhancement, Biomedical Innovations
- Neural and Behavioral Psychology Studies
- Traumatic Brain Injury Research
- Free Will and Agency
- Alzheimer's disease research and treatments
- Face Recognition and Perception
- Deception detection and forensic psychology
- Visual perception and processing mechanisms
- Neurological diseases and metabolism
- Elder Abuse and Neglect
- Infectious Encephalopathies and Encephalitis
- Cognitive Functions and Memory
- Autism Spectrum Disorder Research
- Assistive Technology in Communication and Mobility
- Attention Deficit Hyperactivity Disorder
Vanderbilt University Medical Center
2017-2025
Vanderbilt University
2024-2025
Mayo Clinic in Arizona
2025
Johns Hopkins University
2025
VIB-UAntwerp Center for Molecular Neurology
2024
University of Antwerp
2024
University of California, Los Angeles
2024
NYU Langone Health
2024
Berenson Allen Center for Noninvasive Brain Stimulation
2016-2019
Beth Israel Deaconess Medical Center
2016-2019
Cervical dystonia is a neurological disorder characterized by sustained, involuntary movements of the head and neck. Most cases cervical are idiopathic, with no obvious cause, yet some acquired, secondary to focal brain lesions. These latter valuable as they establish causal link between neuroanatomy resultant symptoms, lending insight into regions causing possible treatment targets. However, lesions can occur in multiple different locations, leaving localization unclear. Here, we use...
Significance Cases like that of Charles Whitman, who murdered 16 people after growth a brain tumor, have sparked debate about why some lesions, but not others, might lead to criminal behavior. Here we systematically characterize such lesions and compare them with cause other symptoms. We find in multiple different areas are associated However, these all fall within unique functionally connected network involved moral decision making. Furthermore, connectivity competing networks predicts the...
Abstract See McKay and Furl (doi: 10.1093/aww323) for a scientific commentary on this article. Focal brain injury can sometimes lead to bizarre symptoms, such as the delusion that family member has been replaced by an imposter (Capgras syndrome). How single lesion could cause complex disorder is unclear, leading many speculate concurrent delirium, psychiatric disease, dementia, or second required. Here we instead propose Capgras other delusional misidentification syndromes arise from lesions...
Human memory is thought to depend on a circuit of connected brain regions, but this hypothesis has not been directly tested. We derive human using 53 case reports strokes causing amnesia and map the connectome (n = 1000). This reproducible across discovery 27) replication 26) cohorts specific lesions amnesia. Its hub at junction presubiculum retrosplenial cortex. Connectivity with single location defines that incorporates > 95% Lesion intersection predicts scores in two independent datasets...
Significance Free will consists of a desire to act (volition) and sense responsibility for that action (agency), but the brain regions responsible these processes remain unknown. We found lesions disrupt volition occur in many different locations, fall within single network, defined by connectivity anterior cingulate. Lesions agency also separate precuneus. Together, networks may underlie our perception free will, with implications neuropsychiatric diseases which are impaired.
Abstract There is both clinical and neuroanatomical variability at the single-subject level in Alzheimer’s disease, complicating our understanding of brain-behaviour relationships making it challenging to develop neuroimaging biomarkers track disease severity, progression, response treatment. Prior work has shown that group-level atrophy dementia syndromes complex neurological symptoms patients with focal brain lesions localize networks. Here, we use a new technique termed ‘atrophy network...
Importance Frontotemporal lobar degeneration (FTLD) is relatively rare, behavioral and motor symptoms increase travel burden, standard neuropsychological tests are not sensitive to early-stage disease. Remote smartphone-based cognitive assessments could mitigate these barriers trial recruitment success, but no such tools validated for FTLD. Objective To evaluate the reliability validity of measures remote FTLD evaluations. Design, Setting, Participants In this cohort study conducted from...
Objective Patients with Alzheimer's disease (AD) have diffuse brain atrophy, but some regions, such as the anterior cingulate cortex (ACC), are spared and may even show increase in size compared to controls. The extent, clinical significance, mechanisms associated increased cortical thickness AD remain unknown. Recent work suggested neural facilitation of regions anticorrelated atrophied frontotemporal dementia. Here, we aim determine whether occurs sporadic AD, it relates symptoms, occur...
Abstract Brain lesions can provide unique insight into the neuroanatomical substrate of human consciousness. For example, brainstem causing coma map to a specific region tegmentum. Whether lesion locations outside are associated with loss consciousness (LOC) remains unclear. Here, we investigate topography cortical prolonged LOC ( N = 16), transient 91), or no 64). Using standard voxel symptom mapping, focus brain damage was LOC. Next, computed network regions functionally connected each...
Background: Psychotic symptoms are common in Alzheimer’s disease (AD) and related neurodegenerative disorders associated with more rapid progression increased mortality. It is unclear to what degree existing criteria utilized clinical research practice. Objective: To establish for the diagnosis of psychosis AD. Methods: The International Society Advance Research Treatment (ISTAART) Neuropsychiatric Symptoms (NPS) Professional Interest Area (PIA) subgroup reviewed AD dementias. Through a...
<h3>Background</h3> Cognitive reserve (CR) is one factor that helps to maintain cognitive function in patients with Alzheimer's disease (AD). Whether the effects of CR depend on semantic/executive components task remains unknown. <h3>Methods</h3> 470 (138 AD, 332 mild impairment (MCI)) were selected from Disease Neuroimaging Initiative database. Linear regression models used determine (years education) performance after controlling for demographic factors and regional cortical atrophy....
Moral and legal responsibility is diminished in neuropsychiatric patients who lack the capacity to use reasoning determine morally appropriate behavior. Patients with behavioral-variant frontotemporal dementia (bvFTD), however, develop immoral behaviors as a result of their disease despite ability explicitly state that behavior wrong. In order whether bvFTD should be held responsible for behavior, we begin by discussing philosophical concepts free will, determinism, responsibility. Those...
Abstract Background Therapeutic development for frontotemporal dementia (FTD) is hindered by the lack of biomarkers that inform susceptibility/risk, prognosis, and underlying causative pathology. Blood glial fibrillary acidic protein (GFAP) has garnered attention as a FTD biomarker. However, investigations GFAP in have been hampered symptomatic histopathologic heterogeneity small cohort sizes contributing to inconsistent findings. Therefore, we evaluated plasma biomarker compared its...
Hyperorality is a core feature of behavioral variant frontotemporal dementia (bvFTD); however, the cognitive, psychiatric, and neuroanatomical correlates hyperorality across bvFTD stages remain unclear. The authors explored these associations in early- advanced-stage bvFTD. Participants with sporadic or genetic were enrolled ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) consortium study. Baseline cognitive psychiatric symptoms participants without compared after...
Abstract INTRODUCTION Sex differences are apparent in neurodegenerative diseases but have not been comprehensively characterized frontotemporal dementia (FTD). METHODS Participants included 337 adults with autosomal dominant FTD enrolled the ALLFTD Consortium. Clinical assessments and plasma were collected annually for up to 6 years. Linear mixed‐effects models investigated how sex disease stage associated longitudinal trajectories of cognition, function, neurofilament light chain (NfL)....
Frontotemporal lobar degeneration (FTLD) is a leading cause of dementia in individuals aged <65 years. Several challenges to conducting in-person evaluations FTLD illustrate an urgent need develop remote, accessible, and low-burden assessment techniques. Studies unobtrusive monitoring at-home computer use older adults with mild cognitive impairment show that declining function reflected reduced use; however, associations smartphone are unknown. This study aims characterize daily trajectories...
has been proposed as a modifier of disease risk in FTLD-TDP, particularly