Michael G. Heckman
A5031027678- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Neurological diseases and metabolism
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Colorectal Cancer Screening and Detection
- Amyotrophic Lateral Sclerosis Research
- Nuclear Receptors and Signaling
- Dementia and Cognitive Impairment Research
- Lysosomal Storage Disorders Research
- Genetic Neurodegenerative Diseases
- RNA regulation and disease
- Acute Myeloid Leukemia Research
- Esophageal and GI Pathology
- Advanced Radiotherapy Techniques
- Gastroesophageal reflux and treatments
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Acute Lymphoblastic Leukemia research
- Neurological disorders and treatments
- Soft tissue tumor case studies
- Sarcoma Diagnosis and Treatment
- Genetic Associations and Epidemiology
Mayo Clinic in Florida
2016-2025
WinnMed
2016-2025
Jacksonville College
2016-2025
Jacksonville University
2016-2024
University of Florida
2024
Mayo Clinic in Arizona
2006-2023
Nemours Children’s Clinic
2020-2023
Heckmann (Germany)
2023
Mayo Clinic
2011-2022
Rush University
2022
<h3>Abstract</h3> Brain-machine interfaces (BMIs) hold promise for the restoration of sensory and motor function treatment neurological disorders, but clinical BMIs have not yet been widely adopted, in part because modest channel counts limited their potential. In this white paper, we describe Neuralink's first steps toward a scalable high-bandwidth BMI system. We built arrays small flexible electrode "threads", with as many 3,072 electrodes per array distributed across 96 threads. also...
Bone marrow aspirate concentrate (BMAC) is increasingly used as a regenerative therapy for musculoskeletal pathological conditions despite limited evidence-based support.BMAC will prove feasible, safe, and efficacious the treatment of pain due to mild moderate degenerative joint disease knee.Randomized controlled trial; Level evidence, 2.In this prospective, single-blind, placebo-controlled trial, 25 patients with bilateral knee from osteoarthritis were randomized receive BMAC into one...
Poly(GP) proteins are a promising pharmacodynamic marker for developing and testing therapeutics treating C9ORF72 -associated amyotrophic lateral sclerosis.
No treatment for frontotemporal dementia (FTD), the second most common type of early-onset dementia, is available, but therapeutics are being investigated to target 2 main proteins associated with FTD pathological subtypes: TDP-43 (FTLD-TDP) and tau (FTLD-tau). Testing potential therapies in clinical trials hampered by our inability distinguish between patients FTLD-TDP FTLD-tau. Therefore, we evaluated truncated stathmin-2 (STMN2) as a proxy pathology, given reports that dysfunction causes...
<h3>Objective</h3> To evaluate whether <i>APOE</i> ε4 is associated with severity of Lewy body (LB) pathology, independently Alzheimer disease (AD) pathology. <h3>Methods</h3> Six hundred fifty-two autopsy-confirmed LB (LBD) cases and 660 clinical controls were genotyped for <i>APOE</i>. In case-control analysis, LBD classified into 9 different groups according to both pathology (brainstem, transitional, diffuse) AD (low, moderate, high) assess associations between risk neuropathologically...
While the accumulation and aggregation of amyloid-β tau are central events in pathogenesis Alzheimer's disease, there is increasing evidence that cerebrovascular pathology also abundant disease brains. In brain capillaries, endothelial cells connected closely with one another through transmembrane tight junction proteins forming blood-brain barrier. Because barrier tightly regulates exchange molecules between blood maintains homeostasis, its impairment increasingly recognized as a critical...
Abstract Familial Parkinson's disease (PD) has been linked to missense and genomic multiplication mutations of the α‐synuclein gene (SNCA) . Genetic variability within SNCA implicated in idiopathic PD many populations. We now confirm extend these findings, a Belgian sample, using high‐resolution map genetic markers across locus. Our study implicates promoter susceptibility PD, more specifically defines minimum haplotype, spanning approximately 15.3kb sequence, which is overrepresented...
Abstract Apolipoprotein E ( APOE ) ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease mainly by modulating amyloid-β pathology. also shown to exacerbate neurodegeneration and neuroinflammation in a tau transgenic mouse model. To further evaluate association of genotype with presence severity pathology, we express human via an adeno-associated virus gene delivery approach targeted replacement mice. We find increased hyperphosphorylated species, aggregates,...
Although exact causes of Parkinson disease (PD) remain enigmatic, mitochondrial dysfunction is increasingly appreciated as a key determinant dopaminergic neuron susceptibility in both familial and sporadic PD. Two genes associated with recessive, early-onset PD encode the ubiquitin (Ub) kinase PINK1 E3 Ub ligase PRKN/PARK2/Parkin, which together orchestrate protective quality control (mitoQC) pathway. Upon stress, enzymes cooperatively identify decorate damaged mitochondria phosphorylated...
A phase 1 study was initiated to determine the safety, potential effectiveness, and maximal tolerated dose recommended 2 of efatutazone paclitaxel in anaplastic thyroid cancer.Patients received (0.15, 0.3, or 0.5 mg) orally twice daily then every 3 weeks. Patient tolerance outcomes were assessed, as serum pharmacokinetics.Ten 15 patients women. Median age 59 years. Seven 0.15 mg efatutazone, 6 0.3 mg, mg. One patient receiving had a partial response from day 69 175; 7 attained stable...
As potential treatments for C9ORF72-associated amyotrophic lateral sclerosis (c9ALS) approach clinical trials, the identification of prognostic biomarkers c9ALS becomes a priority. We show that levels phosphorylated neurofilament heavy chain (pNFH) in cerebrospinal fluid (CSF) predict disease status and survival patients, are largely stable over time. Moreover, patients exhibit higher pNFH levels, more rapid progression, shorter after onset than ALS without C9ORF72 expansions. These data...
Abstract Chronic traumatic encephalopathy is a debilitating neurodegenerative disorder associated with repetitive brain injuries often sustained through prior contact sport participation. The frequency of this in diverse population, including amateur athletes, unknown. Primary historical obituary and yearbook records were queried for 2566 autopsy cases the Mayo Clinic Tissue Registry resulting identification 300 former athletes 450 non‐athletes. In these cases, neocortical tissue was...
Progressive supranuclear palsy (PSP) is a parkinsonian neurodegenerative tauopathy affecting brain regions involved in motor function, including the basal ganglia, diencephalon and brainstem. While PSP largely considered to be sporadic disorder, cases with suspected familial inheritance have been identified common MAPT H1haplotype major genetic risk factor. Due relatively low prevalence of PSP, large sample sizes can difficult achieve, this has limited ability detect true factors at...