A5048912999- Alzheimer's disease research and treatments
- Sepsis Diagnosis and Treatment
- Machine Learning in Healthcare
- Parkinson's Disease Mechanisms and Treatments
- Neurological diseases and metabolism
- Bioinformatics and Genomic Networks
- Amyotrophic Lateral Sclerosis Research
- Artificial Intelligence in Healthcare and Education
- Groundwater and Isotope Geochemistry
- Hemodynamic Monitoring and Therapy
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Electronic Health Records Systems
- Healthcare Technology and Patient Monitoring
- Nuclear Receptors and Signaling
- Mitochondrial Function and Pathology
- Antimicrobial Peptides and Activities
- Emergency and Acute Care Studies
- Airway Management and Intubation Techniques
- Artificial Intelligence in Healthcare
- Anesthesia and Sedative Agents
- Neuroscience and Neuropharmacology Research
- Intensive Care Unit Cognitive Disorders
- Groundwater flow and contamination studies
- Genetic Associations and Epidemiology
New York University
2025
Jacobs (United States)
2023-2024
Cerevel Therapeutics (United States)
2020-2024
Newcastle University
2018-2022
University of Virginia
2012-2021
United States Military Academy
2010-2021
Massachusetts Institute of Technology
2014-2021
National Institutes of Health
1998-2019
University of Toronto
2016-2019
Harvard–MIT Division of Health Sciences and Technology
2017-2019
Objective To examine whether a supplemental remote intensive care unit (ICU) program, implemented by an integrated delivery network using commercial telemedicine and information technology system, can improve clinical economic performance across multiple ICUs. Design Before-and-after trial to assess the effect of adding ICU program. Setting Two adult ICUs large tertiary hospital. Patients A total 2,140 patients receiving between 1999 2001. Interventions The program used intensivists...
Lack of reproducibility in medical studies is a barrier to the generation robust knowledge base support clinical decision-making. In this paper we outline Medical Information Mart for Intensive Care (MIMIC) Code Repository, centralized code generating reproducible on an openly available critical care dataset.Code provided load data into relational structure, create extractions data, and reproduce entire analysis plans including research studies.Concepts extracted include severity illness...
Parkinson disease (PD) is a neurodegenerative disorder pathologically characterized by nigrostriatal dopamine neuron loss and the postmortem presence of Lewy bodies, depositions insoluble α-synuclein, other proteins that likely contribute to cellular toxicity death during disease. Genetic biochemical studies have implicated impaired lysosomal mitochondrial function in pathogenesis PD. Transmembrane protein 175 (TMEM175), K+ channel, centered under major genome-wide association peak for PD,...
<h3>Background</h3> Expression of messenger RNA (mRNA) for the γ-aminobutyric acid(GABA)–synthesizing enzyme, glutamic acid decarboxylase (GAD), in prefrontal cortex and number GABAergic neurons hippocampus are reduced schizophrenia bipolar disorder. We tested hypothesis that expression 2 isoforms, one 65 kd (GAD<sub>65</sub>) other67 (GAD<sub>67</sub>), is differentially affected <h3>Methods</h3> Hippocampal sections from 15 subjects 3 groups (control with disorder) were studied using an...
Estrogen replacement therapy appears to delay the onset of Alzheimer’s disease (AD), but mechanisms for this action are incompletely known. We show how enhancement synaptic sprouting by estradiol (E 2 ) in response an entorhinal cortex (EC) lesion model AD may operate via apolipoprotein E (apoE)-dependent mechanism. In wild-type (WT) mice, ovariectomy decreased commissural/associational inner molecular layer dentate gyrus, with synaptophysin (SYN) as a marker. returned SYN levels...
Abstract Using expression profiles from postmortem prefrontal cortex samples of 624 dementia patients and non‐demented controls, we investigated global disruptions in the co‐regulation genes two neurodegenerative diseases, late‐onset Alzheimer's disease ( AD ) Huntington's HD ). We identified networks differentially co‐expressed DC gene pairs that either gained or lost correlation cases relative to control group, with former dominant for both patterns replicating independent human cohorts...
Synaptic degeneration, including impairment of synaptic plasticity and loss synapses, is an important feature Alzheimer disease pathogenesis. Increasing evidence suggests that these degenerative changes are associated with accumulation soluble oligomeric assemblies amyloid beta (Abeta) known as ADDLs. In primary hippocampal cultures ADDLs bind to a subpopulation neurons. However the molecular basis this cell type-selective interaction not understood. Here, using siRNA screening technology,...
Objectives: To evaluate the relative validity of criteria for identification sepsis in an ICU database. Design: Retrospective cohort study adult admissions from 2008 to 2012. Setting: Tertiary teaching hospital Boston, MA. Patients: Initial admission all patients noncardiac surgical ICUs. Interventions: Comparison five different algorithms retrospectively identifying sepsis, including Sepsis-3 criteria. Measurements and Main Results: 11,791 23,620 (49.9%) met study. Within this subgroup,...
In Alzheimer's disease, there are striking changes in CSF composition that relate to altered choroid plexus (CP) function. Studying CP tissue gene expression at the blood-cerebrospinal fluid barrier could provide further insight into epithelial and stromal responses neurodegenerative disease states.Transcriptome-wide Affymetrix microarrays were used determine disease-related human CP. RNA from post-mortem samples of entire lateral ventricular was extracted 6 healthy controls (Ctrl), 7...
BackgroundDespite wide use of severity scoring systems for case-mix determination and benchmarking in the intensive care unit (ICU), possibility bias across ethnicities has not been examined. Guidelines on illness scores to inform triage decisions allocation scarce resources, such as mechanical ventilation, during current COVID-19 pandemic warrant examination possible these models. We investigated performance Acute Physiology Chronic Health Evaluation IVa (APACHE IVa), Oxford Severity...
The pathogenesis and clinical heterogeneity of Parkinson's disease (PD) have been evaluated from molecular, pathophysiological, perspectives. High-throughput proteomic analysis cerebrospinal fluid (CSF) opened new opportunities for scrutinizing this heterogeneity. To date, is the most comprehensive CSF-based proteomics profiling study in PD with 569 patients (350 idiopathic patients, 65 GBA + mutation carriers 154 LRRK2 carriers), 534 controls, 4135 proteins analyzed. Combining CSF...