A5061226868- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- Neural and Behavioral Psychology Studies
- Mental Health Research Topics
- Electrical and Bioimpedance Tomography
- Neuroscience and Neural Engineering
- Visual perception and processing mechanisms
- Dementia and Cognitive Impairment Research
- Parkinson's Disease Mechanisms and Treatments
- Epilepsy research and treatment
- Phytochemicals and Antioxidant Activities
- Psychosomatic Disorders and Their Treatments
- Blind Source Separation Techniques
- Hemispheric Asymmetry in Neuroscience
- Neural Networks and Applications
- Stroke Rehabilitation and Recovery
- Traditional Chinese Medicine Studies
- Neuroscience and Music Perception
- Neurobiology of Language and Bilingualism
- Acupuncture Treatment Research Studies
Peking University
2022-2025
Massachusetts General Hospital
2015-2024
Athinoula A. Martinos Center for Biomedical Imaging
2015-2024
Harvard University
2014-2024
Jiangsu University
2024
Pioneer (United States)
2023-2024
Medical University of South Carolina
2019-2024
Zhejiang Wanli University
2014-2024
Capital Medical University
2018-2024
Beijing Anding Hospital
2024
Information processing in the cerebral cortex involves interactions among distributed areas. Anatomical connectivity suggests that certain areas form local hierarchical relations such as within visual system. Other patterns, particularly association areas, suggest presence of large-scale circuits without clear relations. In this study organization networks human cerebrum was explored using resting-state functional MRI. Data from 1,000 subjects were registered surface-based alignment. A...
The striatum is connected to the cerebral cortex through multiple anatomical loops that process sensory, limbic, and heteromodal information. Tract-tracing studies in monkey reveal these corticostriatal connections form stereotyped patterns striatum. Here organization of was explored human with resting-state functional connectivity MRI (fcMRI). Data from 1,000 subjects were registered nonlinear deformation combination surface-based alignment cortex. fcMRI maps derived seed regions placed...
Recent evidence suggests that some brain areas act as hubs interconnecting distinct, functionally specialized systems. These nexuses are intriguing because of their potential role in integration and also they may augment metabolic cascades relevant to disease. To identify regions high connectivity the human cerebral cortex, we applied a computationally efficient approach map degree intrinsic functional across brain. Analysis two separate magnetic resonance imaging datasets (each n = 24)...
Resting-state functional magnetic resonance imaging (rs-fMRI) offers the opportunity to delineate individual-specific brain networks. A major question is whether network topography (i.e., location and spatial arrangement) behaviorally relevant. Here, we propose a multi-session hierarchical Bayesian model (MS-HBM) for estimating cortical networks investigate can predict human behavior. The multiple layers of MS-HBM explicitly differentiate intra-subject (within-subject) from inter-subject...
Significance Brain stimulation is a powerful treatment for an increasing number of psychiatric and neurological diseases, but it unclear why certain sites work or where in the brain best place to stimulate treat given patient disease. We found that although different types are applied locations, targets used same disease most often nodes network. These results suggest networks might be understand works improve therapy by identifying places brain.
A traditional and widely used approach for linking neurological symptoms to specific brain regions involves identifying overlap in lesion location across patients with similar symptoms, termed mapping. This is powerful broadly applicable, but has limitations when do not localize a single region or stem from dysfunction connected the site rather than itself. newer sensitive such network effects functional neuroimaging of patients, this requires specialized scans beyond routine clinical data,...
Information processing in the human brain arises from both interactions between adjacent areas and distant projections that form distributed systems. Here we map across different spatial scales by estimating degree of intrinsic functional connectivity for local (≤14 mm) neighborhood directly surrounding regions as contrasted with (>14 interactions. The balance measured at rest forms a separates sensorimotor cortices heteromodal association further identifies possess high cortical-cortical...
Cerebral lateralization is a fundamental property of the human brain and marker successful development. Here we provide evidence that multiple mechanisms control asymmetry for distinct systems. Using intrinsic activity to measure in 300 adults, mapped most strongly lateralized regions. Both men women showed strong asymmetries with significant, but small, group difference. Factor analysis on asymmetric regions revealed 4 separate factors each accounted significant variation across subjects....
How human beings integrate information from external sources and internal cognition to produce a coherent experience is still not well understood. During the past decades, anatomical, neurophysiological neuroimaging research in multimodal integration have stood out effort understand perceptual binding properties of brain. Areas lateral occipitotemporal, prefrontal, posterior parietal cortices been associated with sensory processing. Even though this, rather patchy, organization brain regions...
Significance This study expands our understanding of head motion in brain imaging. Complementing the common knowledge that artifacts can distort connectivity measures by causing artifacts, this identifies a neurobiological trait is linked to differences motion. correlate consists reduced distant functional primarily default network areas individuals with high Importantly, stable within across time. These findings may revise interpretations imaging many neurodevelopmental, aging, and...
To characterize a brainstem location specific to coma-causing lesions, and its functional connectivity network.We compared 12 lesions 24 control using voxel-based lesion-symptom mapping in case-control design identify site significantly associated with coma. We next used resting-state from healthy cohort network of regions functionally connected this site. further investigated the cortical by comparing their spatial topography that known networks evaluating patients disorders consciousness.A...
Cervical dystonia is a neurological disorder characterized by sustained, involuntary movements of the head and neck. Most cases cervical are idiopathic, with no obvious cause, yet some acquired, secondary to focal brain lesions. These latter valuable as they establish causal link between neuroanatomy resultant symptoms, lending insight into regions causing possible treatment targets. However, lesions can occur in multiple different locations, leaving localization unclear. Here, we use...
Abstract A pervasive dilemma in neuroimaging is whether to prioritize sample size or scan time given fixed resources. Here, we systematically investigate this trade-off the context of brain-wide association studies (BWAS) using functional magnetic resonance imaging (fMRI). We find that total duration (sample × per participant) robustly explains individual-level phenotypic prediction accuracy via a logarithmic model, suggesting and are broadly interchangeable up 20-30 min data. However,...
Abstract It is proposed that (a) creativity and innovation are the result of continuously repetitive processes working memory learned as cognitive control models in cerebellum, (b) these cerebellar consist multiple-paired predictor (forward) within MOdular Selection Identification for Control (MOSAIC) hierarchical MOSAIC (HMOSAIC) architectures explore test problem-solving requirements, (c) when resulting newly formed predictor/controller fed forward to more efficiently operations memory,...
The human brain demonstrates functional specialization, including strong hemispheric asymmetries. Here specialization was explored using fMRI by examining the degree to which networks preferentially interact with ipsilateral as opposed contralateral networks. Preferential within-hemisphere interaction prominent in heteromodal association cortices and minimal sensorimotor cortices. frontoparietal control network exhibited interactions but distinct patterns each hemisphere. coupled default...
The brain is a dynamic, flexible network that continuously reconfigures. However, the neural underpinnings of how state-dependent variability dynamic functional connectivity (vdFC) relates to cognitive flexibility are unclear. We therefore investigated during resting-state and task-state magnetic resonance imaging (rs-fMRI t-fMRI, resp.) performed separate, out-of-scanner neuropsychological testing. hypothesize vdFC between frontoparietal (FPN) default mode (DMN) flexibility. Seventeen...
A fundamental characteristic of neural circuits is the capacity for plasticity in response to experience. Neural associated with development chronic pain disorders. In this study, we investigated 1) brain resting state functional connectivity (FC) differences between patients low back (cLBP) and matched healthy controls (HC); 2) FC within cLBP as they experienced different levels endogenous evoked by exercise maneuvers, 3) morphometric HC We found dynamic character primary somatosensory...
Intrinsic functional connectivity detected by MRI (fMRI) provides a useful but indirect approach to study the organization of human brain systems. An unresolved question is whether measured resting-state fMRI reflects anatomical connections. In this study, we used well-characterized anatomy cerebrocerebellar circuits directly test intrinsic associated with an anatomic pathway. Eleven first-episode stroke patients were scanned five times during period 6 months, and 11 healthy control subjects...
Asymmetry of the human cerebellum was investigated using intrinsic functional connectivity. Regions asymmetry within were identified during resting-state MRI ( n = 500 subjects) and replicated in an independent cohort subjects). The most strongly right lateralized cerebellar regions fell posterior lobe, including crus I II, estimated to link cerebral association cortex. left located lobules VI VIII linked distinct networks. Comparison with independently revealed that belong same networks are...
Hemispheric specialization of the human brain is a marker successful neurodevelopment. Altered asymmetry that has been repeatedly reported in schizophrenia may represent consequences disrupted neurodevelopment disorder. However, complete picture functional schizophrenic and its connectional substrates yet to be unveiled.